Association between components of metabolic syndrome and periodontitis: a systematic review and meta-analysis

Campos, Julya Ribeiro; Martins, Carolina Castro; Faria, Sandro Felipe Santos; Carvalho, Ana Paula Mendes; Pereira, Alexandre Godinho; Costa, Fernando Oliveira; Cota, Luís Otávio Miranda

doi:10.1007/s00784-022-04583-x

Cited by 17 publications

(18 citation statements)

References 72 publications

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“…Ellulu et al state that adipose tissues release inflammatory mediators and is associated with a multitude of diseases [ 32 ]. In this line of thought, a recent review showed a dose–response relationship between the metabolic syndrome and severity and periodontitis [ 33 ]. Furthermore, it was demonstrated that obese implant patients show higher BOP, PD and MBL than non-obese controls [ 34 ].…”

Section: Discussionmentioning

confidence: 99%

Clinical outcomes of different implant types in mandibular bar-retained overdentures: a retrospective analysis with up to 20 years follow-up

et al. 2022

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Purpose To determine the clinical and radiological outcomes of hybrid-design- (HD) and bone-level (BL) implants for bar-retained mandibular implant-overdentures (IODs). Methods For this retrospective study, edentulous patients who had received maxillary complete dentures and mandibular bar-retained IODs were invited for a follow-up assessment. Implant survival, implant success and health of peri-implant tissues were assessed on an implant level-based analysis. Patient-based parameters served to identify risk factors for peri-implant bone loss, presence of peri-implantitis and success. Results Eighty patients (median age 72.72 [67.03; 78.81] years, 46 females) with 180 implants (median follow-up 12.01 [10.82; 21.04] years) were assessed. There was no difference concerning the rate of implant failure (p = 0.26), or peri-implantitis (p = 0.97) between HD and BL implants. Solely in one study group, there was the presence of peri-implant pus. Implant success was higher in BL implants with one group being notably higher than the comparing groups (p = 0.045). For bone loss, a width of keratinized mucosa (KM) ≤ 1 mm (p = 0.0006) and the presence of xerostomia (p = 0.09) were identified as risk factors. Smoking (p = 0.013) and a higher body mass index (BMI) (p = 0.03) were a risk factor for peri-implantitis. As risk factors for reduced implant success, a small width of KM (p = 0.003) and the presence of xerostomia (p = 0.007) were identified. Conclusions For mandibular bar-retained IODs, both BL and HD implants are mostly successful. A minimum of 1 mm KM around implants and normal salivary flow are relevant factors for implant success and stable peri-implant bone levels. Smoking and a high BMI are potential risk factors for peri-implantitis.

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Section: Discussionmentioning

confidence: 99%

Clinical outcomes of different implant types in mandibular bar-retained overdentures: a retrospective analysis with up to 20 years follow-up

et al. 2022

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“…488 While the presence of 1 component of MetS implied a periodontal disease OR = 1.14, the presence of 4 or 5 elements increased the OR to 2.02. 488 The biological explanation regarding this connection has been related to an increased inflammatory response and the higher systemic oxidative stress caused by Mets. 490,491 A significant component of this exacerbated inflammation may be macrophages, as these cells are key not only for periodontal inflammation but also for osteoclastogenesis, alveolar loss and tissue homeostasis.…”

Section: Metabolicsyndromementioning

confidence: 98%

“…Individuals with MetS are 38% more likely to present periodontal diseases than a normal population without these pathologies 487 . Indeed, a dose–response gradient between the number of pathologies of MetS and periodontal diseases was found 488 . While the presence of 1 component of MetS implied a periodontal disease OR = 1.14, the presence of 4 or 5 elements increased the OR to 2.02 488 .…”

Section: Host‐related Factors Altering Bone Metabolismmentioning

confidence: 98%

“…481 Metabolic syndrome and periodontal diseases have been clearly linked. [486][487][488][489] Individuals with MetS are 38% more likely to present periodontal diseases than a normal population without these pathologies. 487 Indeed, a dose-response gradient between the number of pathologies of MetS and periodontal diseases was found.…”

Section: Metabolicsyndromementioning

confidence: 99%

“…Metabolic syndrome and periodontal diseases have been clearly linked 486–489 . Individuals with MetS are 38% more likely to present periodontal diseases than a normal population without these pathologies 487 .…”

Section: Host‐related Factors Altering Bone Metabolismmentioning

confidence: 99%

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Emerging factors affecting peri‐implant bone metabolism

Insua,

Galindo‐Moreno,

Miron

et al. 2023

Periodontology 2000

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Implant dentistry has evolved to the point that standard implant osseointegration is predictable. This is attributed in part to the advancements in material sciences that have led toward improvements in implant surface technology and characteristics. Nonetheless, there remain several cases where implant therapy fails (specifically at early time points), most commonly attributed to factors affecting bone metabolism. Among these patients, smokers are known to have impaired bone metabolism and thus be subject to higher risks of early implant failure and/or late complications related to the stability of the peri‐implant bone and mucosal tissues. Notably, however, emerging data have unveiled other critical factors affecting osseointegration, namely, those related to the metabolism of bone tissues. The aim of this review is to shed light on the effects of implant‐related factors, like implant surface or titanium particle release; surgical‐related factors, like osseodensification or implanted biomaterials; various drugs, like selective serotonin reuptake inhibitors, proton pump inhibitors, anti‐hypertensives, nonsteroidal anti‐inflammatory medication, and statins, and host‐related factors, like smoking, diet, and metabolic syndrome on bone metabolism, and aseptic peri‐implant bone loss. Despite the infectious nature of peri‐implant biological complications, these factors must be surveyed for the effective prevention and management of peri‐implantitis.

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