Association Between Confocal Morphologic Classification and Clinical Phenotypes of Multiple Primary and Familial Melanomas

Grazziotin, Thaís Corsetti; Alarcón, Ivette; Bonamigo, Renan Rangel; Carrera, Cristina; Potrony, Míriam; Aguilera, Paula; Puig‐Butillé, J.A.; Brito, Johanna; Badenas, Cèlia; Alós, Llúcia; Malvehy, Josep; Puig, Susana

doi:10.1001/jamadermatol.2016.1189

Cited by 13 publications

(15 citation statements)

References 21 publications

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“…Another subgroup of patients at high risk of developing advanced melanoma, despite participating in DDFU pro grammes, are patients carrying mutations in the MITF gene. These patients often have over 200 naevi and are susceptible to developing fastgrowing nodular mela nomas, which can grow to a thickness of 1 mm within 2 months (55). Early diagnosis of melanomas in these patients relies on patient education, with patients perfor ming regular examinations of the skin and reporting any new lesions persisting for more than 2 weeks for further investigation.…”

Section: Results Of 10-year Follow-up Of a High-risk Target Populatiomentioning

confidence: 99%

Dermoscopy, Digital Dermoscopy and Other Diagnostic Tools in the Early Detection of Melanoma and Follow-up of High-risk Skin Cancer Patients

Thomas¹,

Puig²

2017

Acta Derm Venerol

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Early detection is a key strategy for reducing the mortality and economic burden associated with melanoma. Dermoscopy is a non-invasive and cost-effective tool for melanoma diagnosis, which has been shown to be a reliable and sensitive method for detecting early-stage skin cancer and reducing the number of unnecessary excisions. Patients at high risk of developing melanoma require long-term surveillance. Use of digital dermoscopy follow-up of these patients has led to improved outcomes. Combined follow-up programmes using total-body photography and digital dermoscopy have led to further improvements in early diagnosis and diagnostic accuracy. Dermoscopy is now widely used by dermatologists, but the public health impact of this tool is yet to be evaluated. Despite the clear advantages of dermoscopy and digital follow-up meth-ods, dermoscopy training and access to digital dermoscopy among dermatologists and general practitioners needs to be improved.

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Section: Results Of 10-year Follow-up Of a High-risk Target Populatiomentioning

confidence: 99%

Dermoscopy, Digital Dermoscopy and Other Diagnostic Tools in the Early Detection of Melanoma and Follow-up of High-risk Skin Cancer Patients

Thomas¹,

Puig²

2017

Acta Derm Venerol

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“…No classical melanoma features (e.g. dendritic or roundish hyperrefractile cells) were visible in the epidermis. Nests in melanoma and melanocytic benign lesions are almost always hyperrefractile at RCM, whereas hyporefractile nests are usually features detected in basal cell carcinomas.…”

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confidence: 87%

Amelanotic melanoma in oculocutaneous albinism: a genetic, dermoscopic and reflectance confocal microscopy study

et al. 2017

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“…[ ] In detail, CD271 immunohistochemical expression has been associated with the presence of cerebriform nests and dense and sparse cell aggregations, indicative of RCM CM type 3 . In a study of familial CMs, no association was found between CDKN2A mutations and RCM CM types …”

Section: Introductionmentioning

confidence: 99%

Melanoma types by in vivo reflectance confocal microscopy correlated with protein and molecular genetic alterations: A pilot study

Beretti

Bertoni

Farnetani

et al. 2019

Experimental Dermatology

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Cutaneous melanoma (CM) is one of the most prevalent skin cancers, which lacks both a prognostic marker and a specific and lasting treatment, due to the complexity of the disease and heterogeneity of patients. Reflectance confocal microscopy (RCM) in vivo analysis is a versatile approach offering immediate morphological information, enabling the identification of four primary cutaneous RCM CM types. Whether RCM CM types are associated with a specific protein and molecular genetic profiles at the tissue level remains unclear. The current pilot study was designed to identify potential correlations between RCM CM types and specific biological characteristics, combining immunohistochemistry (IHC) and molecular analyses. Eighty primary CMs evaluated at patient bedside with RCM (type 1 [19, 24%], type 2 [12, 15%], type 3 [7, 9%] and type 4 [42, 52%]) were retrospectively evaluated by IHC stains (CD271, CD20, CD31, cyclin D1), fluorescence in situ hybridization FISH for MYC gain and CDKN2A loss and molecular analysis for somatic mutations (BRAF, NRAS and KIT). RCM CM types correlated with markers of stemness property, density of intra‐tumoral lymphocytic B infiltrate and cyclin D1 expression, while no significant association was found with blood vessel density nor molecular findings. RCM CM types show a different marker profile expression, suggestive of a progression and an increase in aggressiveness, according to RCM morphologies.

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Association Between Confocal Morphologic Classification and Clinical Phenotypes of Multiple Primary and Familial Melanomas

Cited by 13 publications

References 21 publications

Dermoscopy, Digital Dermoscopy and Other Diagnostic Tools in the Early Detection of Melanoma and Follow-up of High-risk Skin Cancer Patients

Dermoscopy, Digital Dermoscopy and Other Diagnostic Tools in the Early Detection of Melanoma and Follow-up of High-risk Skin Cancer Patients

Amelanotic melanoma in oculocutaneous albinism: a genetic, dermoscopic and reflectance confocal microscopy study

Melanoma types by in vivo reflectance confocal microscopy correlated with protein and molecular genetic alterations: A pilot study

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