Association Between Congenital Heart Defects and Small for Gestational Age

Malik, Sadia; Cleves, Mario A.; Zhao, Wei‐Li; Correa, Adolfo; Hobbs, Charlotte A.

doi:10.1542/peds.2006-2742

Cited by 113 publications

(114 citation statements)

References 37 publications

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“…The frequency of infants who were SGA (21.5%) is comparable to the rate (15.2%) reported in Malik et al, 14 which described an association between CHDs and SGA in a population-based study. However, we did not find SGA to be independently associated with hospital mortality.…”

Section: (33%)supporting

confidence: 82%

The effect of late preterm birth on mortality of infants with major congenital heart defects

et al. 2011

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Objective: We evaluated the effect of late preterm delivery (34 to 36 weeks) on hospital mortality of infants with congenital heart defects (CHDs).Study Design: Retrospective record review of infants with major CHD born at or after to 34 weeks, cared for in a single tertiary perinatal center between 2002 and 2009. Factors associated with death before discharge from the hospital were ascertained using univariate and multivariate analyses.Result: Of the 753 infants with CHD, 117 were born at late preterm. Using logistic regression analysis, white race (OR; 95% CI) (0.60; 0.39 to 0.95), late preterm delivery (2.70; 1.69 to 4.33), and need for intubation in the delivery room (3.15; 1.92 to 5.17) were independently associated with hospital death. Conclusion:Late preterm birth of infants with major CHDs was independently associated with increased risk of hospital death compared with delivery at more mature gestational ages.

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Section: (33%)supporting

confidence: 82%

The effect of late preterm birth on mortality of infants with major congenital heart defects

et al. 2011

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“…The tissue and allele expression profile of DDC is broadly incompatible with the etiology of SRS, although it is noteworthy that a small number of SRS patients display cardiac defects as well as increased predisposition to congenital heart disease (16). Further studies to increase the number of human heart specimens tested for allele-specific expression would help decipher whether DDC expression in the developing heart, an organ that may indirectly influence fetal growth (35,41,56), could be involved in SRS at 7p12.2.…”

mentioning

confidence: 99%

Genomic Imprinting of Dopa decarboxylase in Heart and Reciprocal Allelic Expression with Neighboring Grb10

Menheniott

Woodfine

Schulz

et al. 2008

Molecular and Cellular Biology

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By combining a tissue-specific microarray screen with mouse uniparental duplications, we have identified a novel imprinted gene, Dopa decarboxylase (Ddc), on chromosome 11. Ddc_exon1a is a 2-kb transcript variant that initiates from an alternative first exon in intron 1 of the canonical Ddc transcript and is paternally expressed in trabecular cardiomyocytes of the embryonic and neonatal heart. Ddc displays tight conserved linkage with the maternally expressed and methylated Grb10 gene, suggesting that these reciprocally imprinted genes may be coordinately regulated. In Dnmt3L mutant embryos that lack maternal germ line methylation imprints, we show that Ddc is overexpressed and Grb10 is silenced. Their imprinting is therefore dependent on maternal germ line methylation, but the mechanism at Ddc does not appear to involve differential methylation of the Ddc_exon1a promoter region and may instead be provided by the oocyte mark at Grb10. Our analysis of Ddc redefines the imprinted Grb10 domain on mouse proximal chromosome 11 and identifies Ddc_exon1a as the first example of a heart-specific imprinted gene.

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“…(30) The latter study found the associations to be valid for all types of CHD tested. Their results did not show a statistically significant relationship between birth weight and incidence of CHD within the VLBW population, although this may have been due to the small numbers involved.…”

Section: Discussionmentioning

confidence: 78%

Is Low Birth Weight Associated With Congenital Heart Disease?

Bage¹,

Bage²

2016

jemds

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BACKGROUNDDaily we see lots of still birth cases and the agony associated with it after carrying the fetus for so many months with the negative outcome it is quite disheartening. Malnutrition is quite rampant in the country as far as the females are concerned and in the name of the religion and rituals, it complicates the issue further. If the mother is malnourished, the chance of low birth weight baby is high.

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Association Between Congenital Heart Defects and Small for Gestational Age

Cited by 113 publications

References 37 publications

The effect of late preterm birth on mortality of infants with major congenital heart defects

The effect of late preterm birth on mortality of infants with major congenital heart defects

Genomic Imprinting of Dopa decarboxylase in Heart and Reciprocal Allelic Expression with Neighboring Grb10

Is Low Birth Weight Associated With Congenital Heart Disease?

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