Association between conventional or blue-light-filtering intraocular lenses and survival in bilateral cataract surgery patients

Potential Protective Role of TRPM7 and Involvement of PKC/ERK Pathway in Blue Light–Induced Apoptosis in Retinal Pigment Epithelium Cells in Vitro

“…Previous studies have shown that the effect of blue light on the retina depends on the frequency bands 43,44 . In addition, blue light exposure induced apoptosis in RPE cells in vitro in duration- and intensity-dependent manner, and 6-hour exposure to 2000 lux is the optimum condition for triggering photodamage in human RPE cells 20,27 .…”

“…41,42 Previous studies have shown that the effect of blue light on the retina depends on the frequency bands. 43,44 In addition, blue light exposure induced apoptosis in RPE cells in vitro in durationand intensity-dependent manner, and 6-hour exposure to 2000 lux is the optimum condition for triggering photodamage in human RPE cells. 20,27 In this study, we successfully established an in vitro blue light damage model by irradiating rodent RPE cells with the light of wavelength range 440 AE 10 nM, and the optimum conditions were as previously described.…”

Association of clear vs blue-light filtering intraocular lenses with mental and behavioral disorders and diseases of the nervous system among patients receiving bilateral cataract surgery

“…Finally, Griepentrog et al found no difference in the risk of developing dementia between BLF and non-BLF IOLs. 27 However, BLF IOLs increased the risk of death compared with non-BLF IOLs which potentially is associated with perturbation of circadian biology by BLF IOLs. 27 The previously conducted investigations had a modest sample size and were relatively selective because they did not analyze a wide spectrum of mental and behavioral disorders and nervous system diseases.…”

“… 27 However, BLF IOLs increased the risk of death compared with non-BLF IOLs which potentially is associated with perturbation of circadian biology by BLF IOLs. 27 The previously conducted investigations had a modest sample size and were relatively selective because they did not analyze a wide spectrum of mental and behavioral disorders and nervous system diseases. They also commonly included only unilateral cataract surgery, which permits blue-light stimulation to exist from the contralateral eye, weakening the study design.…”

Letter to the Editor: The Spectral Bands Task Force: A consensus on the representation of high-energy visible radiation

“…Mainster and colleagues 28 do acknowledge that there is evidence that blue light disrupts circadian rhythms and that mitigating light exposure before bedtime may promote healthy sleep. However, clinicians must consider the possibility that permanent mitigation of visible violet and blue light from the visible-light spectrum, using products such as blue-filtering IOLs, may have unintended consequences, such as abnormal sleep cycles, 29 impaired physical and mental well-being, and increased risk of all-cause mortality 30 . For this reason, wearing removable devices, such as HEV-filtering contact lenses 31 or HEV-filtering spectacles, likely is preferred over fixed HEV-filtering devices, so that the retina can be exposed to ambient blue light for periods of time.…”