Association between cooking fuel and folate insufficiency among pregnant women in Northern China

Xia, Shuangbo; Liu, Jufen; Zhang, Jinjuan; Du, Yushan; Chen, Jingsong; Jin, Lei; Wang, Linlin; Zhang, Xuejuan; Ren, Aiguo

doi:10.1080/09603123.2021.2014419

Cited by 2 publications

(1 citation statement)

References 33 publications

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“…Consistent with our study, a cross-sectional study of Korean housewives showed that while the overall effect of PM 2.5 exposure was a decrease in mean corpuscular volume (MCV) and mean corpuscular hemoglobin (MCH), PM 2.5 was also signi cantly negatively correlated with serum folate levels (Kwag et al 2021). A recent survey of rural Chinese women also supports the idea that long-term use of solid fuels such as coal or wood may lead to insu cient red blood cell folate levels (Xia et al 2023). Several studies from India revealed that PM 2.5 and other respirable particulate matter (RPM) have adverse effects on the hematological characteristics of anemic children, trained and sedentary male athletes (Mishra and Retherford 2007) (Mehta et al 2021; Das and Chatterjee 2015).…”

Section: Discussionmentioning

confidence: 87%

Risk analysis of air pollutants and types of anemia: a UK Biobank prospective cohort study

Li,

Ran,

Zhuang

et al. 2024

Int J Biometeorol

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Background:Previous studies have suggested that exposure to air pollutants may be associated with speci c blood indicators or anemia in certain populations. However, there is insu cient epidemiological data and prospective evidence to evaluate the relationship between environmental air pollution and speci c types of anemia. Methods:We conducted a large-scale prospective cohort study based on the UK Biobank. Annual average concentrations of NO 2 , PM 2.5 , PM 2.5−10 , and PM 10 were obtained from the ESCAPE study using the Land Use Regression (LUR) model. The association between atmospheric pollutants and different types of anemia was investigated using the Cox proportional hazards model. Furthermore, restricted cubic splines were used to explore exposure-response relationships for positive associations, followed by strati cation and effect modi cation analyses by gender and age. Results:After adjusting for demographic characteristics, 3-4 of the four types of air pollution were signi cantly associated with an increased risk of iron de ciency, vitamin B12 de ciency and folate de ciency anemia, while there was no signi cant association with other de ned types of anemia. After full adjustment, we estimated that the hazard ratios (HRs) of iron de ciency anemia associated with each 10µg/m 3 increase in NO 2 , PM 2.5 , and PM 10 were 1.04 (95%CI: 1.02, 1.07), 2.00 (95%CI: 1.71, 2.33), and 1.10 (95%CI: 1.02, 1.20) respectively. The HRs of folate de ciency anemia with each 10µg/m 3 increase in NO 2 , PM 2.5 ,

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Section: Discussionmentioning

confidence: 87%

Risk analysis of air pollutants and types of anemia: a UK Biobank prospective cohort study

Li,

Ran,

Zhuang

et al. 2024

Int J Biometeorol

View full text Add to dashboard Cite

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Risk analysis of air pollutants and types of anemia: a UK Biobank prospective cohort study

Li,

Ran,

Zhuang

et al. 2024

Preprint

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Background: Previous studies have suggested that exposure to air pollutants may be associated with specific blood indicators or anemia in certain populations. However, there is insufficient epidemiological data and prospective evidence to evaluate the relationship between environmental air pollution and specific types of anemia. Methods: We conducted a large-scale prospective cohort study based on the UK Biobank. Annual average concentrations of NO2, PM2.5, PM2.5−10, and PM10 were obtained from the ESCAPE study using the Land Use Regression (LUR) model. The association between atmospheric pollutants and different types of anemia was investigated using the Cox proportional hazards model. Furthermore, restricted cubic splines were used to explore exposure-response relationships for positive associations, followed by stratification and effect modification analyses by gender and age. Results: After adjusting for demographic characteristics, 3–4 of the four types of air pollution were significantly associated with an increased risk of iron deficiency, vitamin B12 deficiency and folate deficiency anemia, while there was no significant association with other defined types of anemia. After full adjustment, we estimated that the hazard ratios (HRs) of iron deficiency anemia associated with each 10µg/m3 increase in NO2, PM2.5, and PM10 were 1.04 (95%CI: 1.02, 1.07), 2.00 (95%CI: 1.71, 2.33), and 1.10 (95%CI: 1.02, 1.20) respectively. The HRs of folate deficiency anemia with each 10µg/m3 increase in NO2, PM2.5, PM2.5−10, and PM10 were 1.25 (95%CI: 1.12, 1.40), 4.61 (95%CI: 2.03, 10.47), 2.81 (95%CI: 1.11, 7.08), and 1.99 (95%CI: 1.25, 3.15) respectively. For vitamin B12 deficiency anemia, no significant association with atmospheric pollution was found. Additionally, we estimated almost linear exposure-response curves between air pollution and anemia, and interaction analyses suggested that gender and age did not modify the association between air pollution and anemia. Conclusion Our research provided reliable evidence for the association between long-term exposure to PM10, PM2.5, PM2.5−10, NO2, and several types of anemia. NO2, PM2.5, and PM10 significantly increased the risk of iron deficiency anemia and folate deficiency anemia. Additionally, we found that the smaller the PM diameter, the higher the risk, and folate deficiency anemia was more susceptible to air pollution than iron deficiency anemia. No association was observed between the four types of air pollution and hemolytic anemia, aplastic anemia, and other types of anemia. Although the mechanisms are not well understood, we emphasize the need to limit the levels of PM and NO2 in the environment to reduce the potential impact of air pollution on folate and iron deficiency anemia.

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Association between cooking fuel and folate insufficiency among pregnant women in Northern China

Cited by 2 publications

References 33 publications

Risk analysis of air pollutants and types of anemia: a UK Biobank prospective cohort study

Risk analysis of air pollutants and types of anemia: a UK Biobank prospective cohort study

Risk analysis of air pollutants and types of anemia: a UK Biobank prospective cohort study

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