Association Between Cortisol, Insulin Resistance and Zinc in Obesity: a Mini-Review

Morais, Jennifer Beatriz Silva; Silva, Juliana; Beserra, Jéssica Batista; Oiveira, Ana Raquel Soares de; Cruz, Kyria Jayanne Clímaco; Melo, Stéfany Rodrigues de Sousa; Nascimento, Ginivaldo Victor Ribeiro do; Macedo, George Fred Soares de

doi:10.1007/s12011-018-1629-y

Cited by 47 publications

(27 citation statements)

References 46 publications

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“…In a recent review, Morais et al [61] describe the close relationships between cortisol, insulin resistance (type 2 diabetes mellitus), zinc and obesity. Cortisol is a hormone and an important regulator of endocrine and metabolic functions.…”

Section: Zinc Deficiency: Influence On Vessels Coagulation and Strokementioning

confidence: 99%

Zinc Deficiency—An Independent Risk Factor in the Pathogenesis of Haemorrhagic Stroke?

2020

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Zinc is an essential trace element for human health and plays a fundamental role in metabolic, immunological and many other biological processes. The effects of zinc are based on the intra- and extracellular regulatory function of the zinc ion (Zn2+) and its interactions with proteins. The regulation of cellular zinc homeostasis takes place via a complex network of metal transporters and buffering systems that react to changes in the availability of zinc in nutrition, chronic diseases, infections and many other processes. Zinc deficiency is associated with impairment of numerous metabolic processes, reduced resistance to infections due to impaired immune functions, changes in skin and its appendages and disorders of wound healing and haemostasis. While ischemic heart attacks (myocardial infarction) occur more frequently with meat-based normal diets, haemorrhagic strokes are more frequently observed with vegetarian/vegan diets. The causes are discussed as deficiencies of various micronutrients, such as vitamin B12, vitamin D, various amino acids and also zinc. In the present review, after a description of the functions of zinc and its resorption, a discussion of daily food intake will follow, with a special focus on the importance of food composition and preparation for the zinc balance. The close interrelationships between proteins, especially albumin and zinc will be discussed. Finally, the possible causes and consequences of a zinc deficiency on the blood vessels and blood coagulation are considered.

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Section: Zinc Deficiency: Influence On Vessels Coagulation and Strokementioning

confidence: 99%

Zinc Deficiency—An Independent Risk Factor in the Pathogenesis of Haemorrhagic Stroke?

2020

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“…In our study, the concentrations of Zn, Cu, and Fe in maternal serum in the 10-14th week were not associated with LGA risk, although these microelements are also associated with metabolic disorders, such as insulin resistance as well as diabetes mellitus and obesity [16][17][18]. In their optimal levels, they also have antioxidant and anti-inflammatory properties, and their deficiency or excess may increase inflammation and oxidative stress [15].…”

Section: Discussionmentioning

confidence: 48%

“…Microelements such as selenium (Se), zinc (Zn), copper (Cu), and iron (Fe) have anti-inflammatory and antioxidant properties, and their deficiency or excess can increase inflammation and oxidative stress [14,15]. These microelements are involved in insulin signal cascade regulation, glucose metabolism, and the functions of many hormones [11,[16][17][18]. They also affect cell proliferation and differentiation [2,14,19].…”

Section: Introductionmentioning

confidence: 99%

Serum Microelements in Early Pregnancy and their Risk of Large-for-Gestational Age Birth Weight

Lewandowska

Lubiński

2020

Nutrients

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Excessive birth weight has serious perinatal consequences, and it “programs” long-term health. Mother’s nutritional status can be an important element in fetal “programming”; microelements such as selenium (Se), zinc (Zn), copper (Cu), and iron (Fe) are involved in many metabolic processes. However, there are no studies assessing the relationship of the microelements in the peri-conceptual period with the risk of excessive birth weight. We performed a nested case control study of serum microelements’ levels in the 10–14th week of pregnancy and assessed the risk of large-for-gestational age (LGA) newborns using the data from a prospective cohort of pregnant women recruited in 2015–2016 in Poznań, Poland. Mothers delivering LGA newborns (n = 66) were examined with matched mothers delivering appropriate-for-gestational age (AGA) newborns (n = 264). Microelements’ levels were quantified using mass spectrometry. The odds ratios of LGA (and 95% confidence intervals) were calculated by multivariate logistic regression. In the whole group, women with the lowest quartile of Se had a 3 times higher LGA risk compared with women in the highest Se quartile (AOR = 3.00; p = 0.013). Importantly, the result was sustained in the subgroup of women with the normal pre-pregnancy BMI (AOR = 4.79; p = 0.033) and in women with a male fetus (AOR = 6.28; p = 0.004), but it was not sustained in women with a female fetus. There were no statistical associations between Zn, Cu, and Fe levels and LGA. Our study provides some preliminary evidence for the relationships between lower serum Se levels in early pregnancy and a higher risk of large-for-gestational age birth weight. Appropriate Se intake in the periconceptual period may be important for optimal fetal growth.

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“…Zinc transport relevant proteins play crucial roles in maintaining of zinc homeostasis. Dysfunction of zinc transporters is associated with obesity and diabetes (Quraishi et al 2005;Noh et al 2014;Morais et al 2019). In C. elegans, a total of 28 zinc transport relevant proteins have been identified based on the protein sequences to human homologues (Kambe et al 2015).…”

Section: Discussionmentioning

confidence: 99%

“…Zinc transport relevant proteins are divided into two major families, the zinc transporters or cation diffusion facilitator (ZnTs/CDFs) or solute-linked carrier family 30 (SLC30A), and the Zip (Zrt-and Irt-like proteins) family or solute carrier 39A (SLC39A) (Liuzzi and Cousins 2004;Baltaci and Yuce 2018;Cotrim et al 2019;Thokala et al 2019). Several studies have shown that the gene expression of zinc transporters and disturbed zinc metabolism are associated with obesity and diabetes (Quraishi et al 2005;Noh et al 2014;Morais et al 2019). The polymorphisms (SNP) of ZnT8 are in connection with type (Xu et al 2011; Wenzlau and Hutton 2013) and type diabetes (Rutter and Chimienti 2015;Drake et al 2017;Virgili et al 2018).…”

Section: Introductionmentioning

confidence: 99%

The role of cation diffusion facilitator CDF-1 in lipid metabolism inCaenorhabditis elegans

Wang

et al. 2020

Preprint

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Zinc is one of the most important trace elements that plays a vital role in many biological processes, and aberrant zinc metabolism has been implicated in lipid-related metabolic diseases. Previously, we showed that zinc antagonizes iron to regulate sterol regulatory element-binding proteins and stearoyl-CoA desaturase (SREBP-SCD) pathway in lipid metabolism in model organism Caenorhabditis elegans. Here, we further identified another cation diffusion facilitator CDF-1 in addition to SUR-7 in response to zinc to regulate lipid metabolism. Inactivation of SBP-1, the only homolog of SREBPs, leads to increased zinc level but decreased lipid accumulation reversely. However, either cdf-1(n2527) or sur-7(tm6523) mutation could successfully restore the altered fatty acid profile, fat content and zinc level of sbp-1(ep79) mutant. Furthermore, we found that CDF-1/SUR-7 may function bypass SBP-1 to directly affect the conversion activity of SCD in the biosynthesis of unsaturated fatty acids and lipid accumulation. Collectively, these results consistently support the link between zinc homeostasis and lipid metabolism via SREBP-SCD axis by cation diffusion facilitators CDF-1 and SUR-7.

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Association Between Cortisol, Insulin Resistance and Zinc in Obesity: a Mini-Review

Cited by 47 publications

References 46 publications

Zinc Deficiency—An Independent Risk Factor in the Pathogenesis of Haemorrhagic Stroke?

Zinc Deficiency—An Independent Risk Factor in the Pathogenesis of Haemorrhagic Stroke?

Serum Microelements in Early Pregnancy and their Risk of Large-for-Gestational Age Birth Weight

The role of cation diffusion facilitator CDF-1 in lipid metabolism inCaenorhabditis elegans

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