2012
DOI: 10.1016/j.psychres.2012.07.002
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Association between CYP1A2 polymorphisms and clozapine-induced adverse reactions in patients with schizophrenia

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Cited by 25 publications
(12 citation statements)
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“…Induction of CYP1A2 by the components of cigarette smoke seems to increase clozapine dose requirement, primarily of male smokers (Haring et al, 1989; Tang et al, 2007); however, the patients with the polymorphic CYP1A2*1F allele, resulting in an increase in CYP1A2 inducibility, did not require dose adjustment (Weide et al, 2003). On the other hand, Ferrari et al (2012) demonstrated an association between the frequency of clozapine-induced adverse reactions and the occurrence of the low activity CYP1A2*1C allele in patients. The CYP1A2 substrate caffeine has been reported to inhibit clozapine metabolism, and caffeine consumption in a daily dose of 400 to 1000 mg significantly decreased clozapine clearance (Hagg et al, 2000; Raaska et al, 2004).…”
Section: Discussionmentioning
confidence: 98%
See 1 more Smart Citation
“…Induction of CYP1A2 by the components of cigarette smoke seems to increase clozapine dose requirement, primarily of male smokers (Haring et al, 1989; Tang et al, 2007); however, the patients with the polymorphic CYP1A2*1F allele, resulting in an increase in CYP1A2 inducibility, did not require dose adjustment (Weide et al, 2003). On the other hand, Ferrari et al (2012) demonstrated an association between the frequency of clozapine-induced adverse reactions and the occurrence of the low activity CYP1A2*1C allele in patients. The CYP1A2 substrate caffeine has been reported to inhibit clozapine metabolism, and caffeine consumption in a daily dose of 400 to 1000 mg significantly decreased clozapine clearance (Hagg et al, 2000; Raaska et al, 2004).…”
Section: Discussionmentioning
confidence: 98%
“…CYP2D6*5 (gene deletion) and CYP2D6 duplication were analyzed by TaqMan Copy Number Assay (ThermoFisher Scientific, Waltham, MA). Since CYP1A2 expression was found to be poorly associated with the presence of CYP1A2 SNPs (Ferrari et al, 2012), the patients’ CYP1A2 activity was estimated by CYP1A2 mRNA levels in leukocytes, and not by CYP1A2 -genotype.…”
Section: Methodsmentioning
confidence: 99%
“…Since clozapine strongly inhibits GIRK channels [77], this effect can explain the relationship between GNB3 polymorphisms and seizures in patients exposed to this drug. Two recent studies [78,79] suggested that specific combinations of CYP1A2 *1F and *1C alleles could induce lower messenger RNA (mRNA) expression and predispose to clozapine intolerance. In an attempt to partially corroborate this finding, we evaluated these two polymorphisms in a sample of South Brazilians with schizophrenia and their importance in the proconvulsive effect of clozapine [80].…”
Section: Pgx Of Antipsychotics In Schizophrenic Patientsmentioning
confidence: 99%
“…Ferrari et al 84 studied the influence of CYP1A2 polymorphisms and clozapine-induced adverse effects (neurological, cardiovascular, gastroenterological, hematological, behavioral, and musculoskeletal adverse drug reactions, ADRs) and observed that the LA (low activity) phenotype was significantly more frequent in subjects with clozapine-induced ADRs than in those without ADRs.…”
Section: Studies Assessing the Adverse Effects Of Clozapinementioning
confidence: 99%