Association between cystatin C and inflammation in patients with essential hypertension

Okura, Takafumi; Jotoku, Masanori; Irita, Jun; Enomoto, Daijiro; Nagao, Tetsuhiko; Desilva, Veena Rasika; Yamane, Shiho; Pei, Zuowei; Kojima, Shiho; Hamano, Yasuyuki; Mashiba, Shinichi; Kurata, Mie; Miyoshi, Katsuhiko; Higaki, Jitsuo

doi:10.1007/s10157-010-0334-8

Cited by 81 publications

(66 citation statements)

References 31 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…A correlation between cystatin C and age is to be expected, as GFR declines with age [27]. The association between cystatin C and inflammatory markers has been described by some authors [25,28,29], although this may be expected as inflammation is activated in renal insufficiency. However, the only study adjusted for measured GFR still suggested a weak relationship between CRP and cystatin C [30,31].…”

Section: Discussionmentioning

confidence: 89%

Serum cystatin C as a predictor for cardiovascular events in end-stage renal disease patients at the initiation of dialysis

et al. 2012

View full text Add to dashboard Cite

show abstract

Section: Discussionmentioning

confidence: 89%

Serum cystatin C as a predictor for cardiovascular events in end-stage renal disease patients at the initiation of dialysis

et al. 2012

View full text Add to dashboard Cite

show abstract

“…27,[47][48][49] Further evaluations of the role of cystatin C and its correlation with and regulation by inflammatory cytokines will improve the utility of this protein as a marker of renal function. 50,51 Clearly, there remains the need to further evaluate the utility of cystatin C as a marker of renal function. For the current cohort, we determined the threshold of cystatin C > 1.0 mg/ liter had a positive predictive value of only 0.57 and 0.12 for eGFR < 90 and < 60 ml/min/1.73 m 2 , respectively, and a negative predictive value of 0.64 and 0.99 for eGFR < 90 and < 60 ml/min/1.73 m 2 , respectively (data not shown).…”

mentioning

confidence: 99%

Cystatin C and Baseline Renal Function Among HIV-Infected Persons in the SUN Study

Overton

Patel

Mondy

et al. 2012

AIDS Research and Human Retroviruses

View full text Add to dashboard Cite

In the combination antiretroviral therapy (cART) era, renal dysfunction remains common. The Study to Understand the Natural History of HIV/AIDS in the Era of Effective Therapy (SUN) (ClinicalTrials.gov number, NCT00146419) is a prospective observational cohort study of HIV-infected adults. At baseline, comprehensive data were collected, including cystatin C and measures of renal function. Univariate and multivariate regression analyses were performed to identify factors associated with baseline renal dysfunction [estimated glomerular filtration rate (eGFR) < 90 ml/min/1.73 m 2 calculated using the simplified Modification of Diet in Renal Disease equation] and elevated cystatin C ( > 1.0 mg/liter) in a cross-sectional analysis. Among 670 subjects with complete data (mean age 41 years, mean CD4 cell count 530 cells/mm 3 , 79% prescribed cART), the mean eGFR was 96.8 ml/min/1.73 m 2 . Forty percent of subjects had renal dysfunction; 3.3% had chronic kidney disease (eGFR < 60 ml/min/1.73 m 2 ). Elevated cystatin C was present in 18% of subjects. In multivariate analysis, renal dysfunction was associated with older age, non-Hispanic white race/ethnicity, higher body mass index (BMI), hypertension, higher cystatin C levels, and current prescription of ritonavir. Factors associated with elevated cystatin C included hepatitis C coinfection, hypertension, current smoking, older age, current tenofovir use, detectable plasma HIV RNA, and elevated microalbuminuria. The prevalence of chronic kidney disease (CKD) was low in this contemporary HIV cohort. However, mild to moderate renal dysfunction was common despite the widespread use of cART.

show abstract

“…In adult kidney transplant receipients, cystatin C levels have been reported to be increased in a dose-dependent fashion in steroid use (35). In addition, cystatin C levels are known to be affected by systemic inflammatory conditions atherosclerosis and hypertension, presence of thyroid dysfunction and tumor (36)(37)(38)(39). These interactions should be considered in clinical practice.…”

Section: Discussionmentioning

confidence: 99%

Sistatin C: böbrek işlevleri azalmakta olan çocuklarda glomerüler filtrasyon hızı ölçümünde daha yararlı bir değişken olabilir mi?

Yıldız¹,

Çalışkan²,

Kabasakal³

et al. 2011

tpa

View full text Add to dashboard Cite

I Is s c cy ys st ta at ti in n C C a a m mo or re e r re el li ia ab bl le e m ma ar rk ke er r f fo or r e es st ti im ma at ti io on n o of f g gl lo om me er ru ul la ar r f fi il lt tr ra at ti io on n r ra at te e i in n c ch hi il ld dr re en n w wi it th h r re ed du uc ce ed d r re en na al l f fu un nc ct ti io on n? ? N Nu ur rd da an n Y Y› ›l ld d› ›z z, , S Sa al li im m Ç Ça al l› ›fl flk ka an n* *, , L Le ev ve en nt t K Ka ab ba as sa ak ka al l* ** *, , L La al le e S Se ev ve er r* *, , N Ni il l A Ar r› ›s so oy y* * O Or ri ig gi in na al l A Ar rt ti ic cl le e S Su um mm ma ar ry y Aim: The aim of this study was to evaluate whether serum cystatin C is superior as a marker of glomerular filtration rate calculation compared to creatinine in children with reduced renal functions. Material and Method:Serum cystatin C, creatinine and 99Tc-diethylenetriamene penta acetate (DTPA) clearance (GFRDTPA) were measured in 100 children (53 girls, 47 boys; mean age 8.4±5.1). Glomerular filtration rate was calculated by the Schwartz formula. Patients with DTPA clearance which was accepted as the gold standard in the study with a value above 80 ml/dk/1.73m2 were included in group 1(n=64) and below 80 ml/dk/1.73m2 in group 2 (n=36). Receiver-operating characteristics analysis was performed to assess the diagnostic accuracy of variables. Signed informed consents were obtained from the parents in all cases.Results: : Serum cystatin C and creatinine were correlated with glomerular filtration rate in group 1 and 2. Dietilen triamin penta asetat (DTPA) clearance was correlated with glomerular filtration rate in both groups and with cystatin C in group 2. Receiver-operating characteristics analysis showed that the accuracy of cystatin C and glomerular filtration rate was similar. The area under curve values were statistically significant but not different for cystatin C and GFRSchw.Conclusions: Serum cystatin C may be a useful variable, but is not superior to glomerular filtration rate calculated by Schwartz formula which is a simple and reliable method to estimate glomerular filtration rate in children with normal and decreased renal functions. (Turk Arch Ped 2011; 46: 111-6)

show abstract

Association between cystatin C and inflammation in patients with essential hypertension

Abstract: This study showed that cystatin C is a marker of inflammation as well as renal function.

Cited by 81 publications

References 31 publications

Serum cystatin C as a predictor for cardiovascular events in end-stage renal disease patients at the initiation of dialysis

Serum cystatin C as a predictor for cardiovascular events in end-stage renal disease patients at the initiation of dialysis

Cystatin C and Baseline Renal Function Among HIV-Infected Persons in the SUN Study

Sistatin C: böbrek işlevleri azalmakta olan çocuklarda glomerüler filtrasyon hızı ölçümünde daha yararlı bir değişken olabilir mi?

Contact Info

Product

Resources

About