Association between cytomegalovirus infection and neurological disorders: A systematic review

Sanami, Samira; Shamsabadi, Shahnam; Dayhimi, Amir; Pirhayati, Mohammad; Ahmad, Sajjad; Pirhayati, Ahmadreza; Ajami, Marjan; Hemati, Sara; Shirvani, Masoud; Alagha, Ahmad; Abbarin, Davood; Alizadeh, Akram; Pazoki‐Toroudi, Hamidreza

doi:10.1002/rmv.2532

Cited by 3 publications

(1 citation statement)

References 216 publications

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“…Two more recent studies have also attempted to address these discrepancies in the research literature. A comprehensive review by Sanami et al [61] suggested that while HCMV appears to promote immune and inflammatory processes that are associated with biomarkers of Alzheimer's disease, HCMV is more likely a risk factor for Alzheimer's disease and not a causal factor per se. Furthermore, Ji et al [62] used meta-analytic methods to examine the potential association between HCMV and Alzheimer's disease.…”

Section: Hcmv and Dementiamentioning

confidence: 99%

Human Cytomegalovirus Infection and Neurocognitive and Neuropsychiatric Health

Gale,

Farrer,

Erbstoesser

et al. 2024

Pathogens

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A common infection, human cytomegalovirus (HCMV) has been associated with a variety of human diseases, including cardiovascular disease and possibly certain cancers. HCMV has also been associated with cognitive, psychiatric, and neurological conditions. Children with congenital or early-life HCMV are at risk for microcephaly, cerebral palsy, and sensorineural hearing loss, although in many cases sensorineural loss may resolve. In addition, HCMV can be associated with neurodevelopmental impairment, which may improve with time. In young, middle-aged, and older adults, HCMV has been adversely associated with cognitive function in some but not in all studies. Research has linked HCMV to Alzheimer’s and vascular dementia, but again not all findings consistently support these associations. In addition, HCMV has been associated with depressive disorder, bipolar disorder, anxiety, and autism-spectrum disorder, although the available findings are likewise inconsistent. Given associations between HCMV and a variety of neurocognitive and neuropsychiatric disorders, additional research investigating reasons for the considerable inconsistencies in the currently available findings is needed. Additional meta-analyses and more longitudinal studies are needed as well. Research into the effects of antiviral medication on cognitive and neurological outcomes and continued efforts in vaccine development have potential to lower the neurocognitive, neuropsychiatric, and neurological burden of HCMV infection.

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Section: Hcmv and Dementiamentioning

confidence: 99%

Human Cytomegalovirus Infection and Neurocognitive and Neuropsychiatric Health

Gale,

Farrer,

Erbstoesser

et al. 2024

Pathogens

View full text Add to dashboard Cite

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Brain-Region-Specific Differences in Protein Citrullination/Deimination in a Pre-Motor Parkinson’s Disease Rat Model

Mercer,

Sancandi,

Maclatchy

et al. 2024

IJMS

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The detection of early molecular mechanisms and potential biomarkers in Parkinson’s disease (PD) remains a challenge. Recent research has pointed to novel roles for post-translational citrullination/deimination caused by peptidylarginine deiminases (PADs), a family of calcium-activated enzymes, in the early stages of the disease. The current study assessed brain-region-specific citrullinated protein targets and their associated protein–protein interaction networks alongside PAD isozymes in the 6-hydroxydopamine (6-OHDA) induced rat model of pre-motor PD. Six brain regions (cortex, hippocampus, striatum, midbrain, cerebellum and olfactory bulb) were compared between controls/shams and the pre-motor PD model. For all brain regions, there was a significant difference in citrullinated protein IDs between the PD model and the controls. Citrullinated protein hits were most abundant in cortex and hippocampus, followed by cerebellum, midbrain, olfactory bulb and striatum. Citrullinome-associated pathway enrichment analysis showed correspondingly considerable differences between the six brain regions; some were overlapping for controls and PD, some were identified for the PD model only, and some were identified in control brains only. The KEGG (Kyoto Encyclopedia of Genes and Genomes) pathways identified in PD brains only were associated with neurological, metabolic, immune and hormonal functions and included the following: “Axon guidance”; “Spinocerebellar ataxia”; “Hippo signalling pathway”; “NOD-like receptor signalling pathway”; “Phosphatidylinositol signalling system”; “Rap1 signalling pathway”; “Platelet activation”; “Yersinia infection”; “Fc gamma R-mediated phagocytosis”; “Human cytomegalovirus infection”; “Inositol phosphate metabolism”; “Thyroid hormone signalling pathway”; “Progesterone-mediated oocyte maturation”; “Oocyte meiosis”; and “Choline metabolism in cancer”. Some brain-region-specific differences were furthermore observed for the five PAD isozymes (PADs 1, 2, 3, 4 and 6), with most changes in PAD 2, 3 and 4 when comparing control and PD brain regions. Our findings indicate that PAD-mediated protein citrullination plays roles in metabolic, immune, cell signalling and neurodegenerative disease-related pathways across brain regions in early pre-motor stages of PD, highlighting PADs as targets for future therapeutic avenues.

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Association of Infections with Alzheimer’s Disease

Yilmaz

2024

Alzheimer’s Disease From Molecular Mechanisms to Clinical Practices

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Oskar Fischer and Alois Alzheimer first suggested a possible link to infections in 1907. Various infectious agents, including viruses, bacteria, spirochetes, fungi, and prions, have been implicated in its etiology. However, the role of these pathogens in AD is complex and intertwined with numerous other factors. Infections may contribute to AD through several mechanisms. When an infectious agent invades the body, the host’s immune response produces a range of chemicals and proteins that can impact the brain. Additionally, the stress response, environmental factors, and treatments can all interact with infectious agents to influence disease progression. Several pathogens have been specifically studied for their potential role in AD. Fungal infections have also been proposed as a contributing factor. Despite these findings, establishing a clear causative role for infections in AD remains challenging. The interactions between infections and other risk factors highlight the complexity of AD etiology, underscoring the need for comprehensive approaches in both research and treatment to address this debilitating condition. This section discusses the role of infectious agents in the pathogenesis of Alzheimer’s disease.

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Association between cytomegalovirus infection and neurological disorders: A systematic review

Cited by 3 publications

References 216 publications

Human Cytomegalovirus Infection and Neurocognitive and Neuropsychiatric Health

Human Cytomegalovirus Infection and Neurocognitive and Neuropsychiatric Health

Brain-Region-Specific Differences in Protein Citrullination/Deimination in a Pre-Motor Parkinson’s Disease Rat Model

Association of Infections with Alzheimer’s Disease

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