Association Between Cytomegalovirus Infection and Bad Obstetric Outcomes in Women from Kirkuk

Hassan, Hala Mohamed Majeed; Alsamarai, Abdulghani Mohamed; Aljumaili, Zainab Khalil Mohamed; Alobaidi, Amina Hamed Ahmed; Al-Salihi, Ferah Ghali

doi:10.11591/ijphs.v3i1.5378

Cited by 4 publications

(8 citation statements)

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“…The present study aimed to detect HCMV antibodies in pregnant women in the River Nile State, located in the Eastern North and the Kassala State, one of the rural areas in Eastern Sudan, where daily hygiene status is inadequate. Among 184 blood specimens tested for HCMV IgG, 170 (92.4%) were positive, in line with previous reports that rural residents are 92% seropositive for the virus ( Hassan et al 2014 ). This high percentage of seroprevalence was slightly lower than the result obtained in Nigeria, where 97.2% of participants were CMV IgG positive ( Akinbami et al 2011 ), Northern Turkey – 97.3% ( Uyar et al 2008 ), Palestine – 96.6% ( Neirukh et al 2013 ), and in Asir Region, Kingdom of Saudi Arabia the seroprevalence was 95.7–100% ( Almaghrabi et al 2019 ).…”

Section: Discussionsupporting

confidence: 89%

“…Illiteracy and low education levels are associated with an increased likelihood of contracting HCMV through direct contact with infectious secretions from their children and poor hygienic conditions in their homes. Low socioeconomic status also contributes significantly to acquiring HCMV infection ( Hassan et al 2014 ).…”

Section: Discussionmentioning

confidence: 99%

“…Feto-maternal transmission can occur during pregnancy through the placenta, during delivery through direct contact with maternal cervical secretions and blood, and postnatal via breast milk ( Bhide and Papageorghiou 2008 ). Strikingly, transplacental transmission can occur even in women with pre-existing seroimmunity to CMV, which can be explained either by viral reactivation or infection with a new, different strain of CMV (reinfection) during the pregnancy ( Hassan et al 2014 ).…”

Section: Introductionmentioning

confidence: 99%

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Seroepidemiological Survey of Cytomegalovirus Infection among Pregnant Women in Sudan

Moglad,

Hassan,

Atta Elmanan

et al. 2023

Polish Journal of Microbiology

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Human Cytomegalovirus (HCMV) is a leading healthcare problem associated with stillbirth and congenital abnormalities. Determining the seroprevalence and the possible risk factors related to HCMV infections may be a cornerstone in preventing its complications. This cross-sectional study was conducted in Kassala and River Nile States to determine the seroprevalence and risk factors associated with HCMV infection in pregnant women. One hundred eighty-four (n = 184) blood specimens were collected from pregnant women from February 2018 to January 2020. Enzyme-linked immunosorbent assay (ELISA) was used to detect HCMV-specific IgG and IgM antibodies. Socio-demographical characteristics of the women were collected using structured questionnaires. The results showed that HCMV IgG was detected in 170 (92.4%) of the blood specimens, and IgM was detected in 29/93 (31.2%). There was a significant relationship between the history of miscarriage and the presence of IgG and IgM with a p-value = 0.001 and between HCMV IgM and gestational stage (p-value = 0.028). The study found a strikingly high seroprevalence of HCMV infections among pregnant women in the investigated States. This high percentage of illiterate housewives living in rural areas makes it possible to reduce the incidence of HCMV infection in pregnant women by improving their knowledge, attitude, and practice regarding the route of viral transmission, which may reflect in lowering the rate of congenital diseases in their infants.

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Section: Discussionsupporting

confidence: 89%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Seroepidemiological Survey of Cytomegalovirus Infection among Pregnant Women in Sudan

Moglad,

Hassan,

Atta Elmanan

et al. 2023

Polish Journal of Microbiology

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“…In general female population CMV IgG seroprevalence is 51.7-95.7%, while the IgM seroprevalence is 4.1 to 6.3%, while in women with bad obstetric history (BOH) the CMV IgG seroprevalence is with a range of 91.2% -96.6% and 3.8% to 9.46% for IgM seroprevalence [15][16][17][18][19]. The association between CMV infection and age is with conflicting results, however, some study suggest that CMV infection is increased in women with age [16].…”

Section: High-risk Womenmentioning

confidence: 99%

Maternal Infections Associated with Bad Obstetric Outcome: Cytomegalovirus and Herpes Simplex Virus.

Alsamarai¹,

Hassan

2019

Int J Med Sci

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Cytomegalovirus (CMV) infection is with global distribution and range of 30-100%. CMV infection is the most common congenital viral infection worldwide . The sign of congenital CMV infection encountered most frequently is hearing loss, which wills 12.6% of congenitally infected newborns and congenital CMV infection form 10-20% as a cause of total hearing loss in children. About10% of the live-born infants with congenital CMV infection are symptomatic at birth. Where as an additional 10% of the infected newborns will develop permanent sequelae in the following years. Herpes simplex virus (HSV) is an abundant, enveloped, and double stranded DNA virus, belonging to the family of Herpesviridae transmitted across mucosal membranes and non intact skin, with ability to induce chronic latent infection. Susceptibility to HSV infection is associated with HLA antigens. The virus type incidence is about the same for both HSV-1 and HSV-2 strains, while HSV-2 is the most predominant in recurrent infections. HVS -1 is the common strain in labial herpetic infection, while HSV-2 is the predominant in genital infection. The site of latency is the trigeminal ganglia for labial herpetic infection and lumbosacral ganglia for genital herpetic infection. Changes in sexual behaviors of young adults may partly explain its higher incidence.

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“…Angiopoietin-1 plays a vital role in the development of vasculogenesis and angiogenesis in human placenta [7]. Previous studies performed in Iraq indicated a significant association between infections, autoantibodies induction and hormones and bad obstetric outcomes [8][9][10][11][12][13][14][15][16][17][18]. Thus this study was conducted to determine the association between IL-6, IL-17 and angiopoietin in women with BOH in relation to some infections, TPO, TGA, TSH, SES and demographic characteristics.…”

Section: Introductionmentioning

confidence: 99%

Association of Interleukin-6, Interleukin-17 and Angiopoietin in Different Infections, Thyroid Stimulating Hormone, Demographic and Socioeconomic Characteristics in Women with Bad Obstetric History, Kirkuk, Iraq.

2019

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Background: Bad obstetric history [BOH] is associated with microbiological infections and abnormal immunological responses.Study design: Descriptive Case Control Study.Aim: to determine the association of interleukin-6 (IL-6), interleukin-17 (IL-17) and angiopoietin with infectivity inn female within Bad obstetric history, in Kirkuk city, Iraq.Materials and method: The study included 547 Bad obstetric histories within Bad obstetric history and 291 female with normal pregnancy outcome. The test performed to detect IL-6, IL-17 and angiopoietin in 60 women with BOH, of them 20 were pregnant and 20 were non-pregnant at time of enrolment in the study. In addition, 20 female with inevitable abortion be included in the study. Also thee study included 28 women with normal pregnancy as control and 14 of them were pregnant and 14 were non-pregnant. Serological study carried out to determine IL-6, IL-17 and Angiopoietin using ELISA kits.Results: IL-17 significantly lower in parvovirus 19 acute infection. Angiopoietin was significantly lower in Toxoplasma gondii infected women, while IL-6 was significantly higher in acute rubella infection as compared to non-infected. Angiopoietin was significantly higher in women with positive TPO autoantibodies. Smoking, animal exposure and low haemoglobin (<11) were associated with decrease in IL-6, while IL-17 was significantly higher in women with history of animal exposure.Conclusion: IL-6, IL-17 and angiopoietin may be influenced by infections in women with BOH, however, this need to be evaluated in a large scale study.

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Association Between Cytomegalovirus Infection and Bad Obstetric Outcomes in Women from Kirkuk

Cited by 4 publications

References 0 publications

Seroepidemiological Survey of Cytomegalovirus Infection among Pregnant Women in Sudan

Seroepidemiological Survey of Cytomegalovirus Infection among Pregnant Women in Sudan

Maternal Infections Associated with Bad Obstetric Outcome: Cytomegalovirus and Herpes Simplex Virus.

Association of Interleukin-6, Interleukin-17 and Angiopoietin in Different Infections, Thyroid Stimulating Hormone, Demographic and Socioeconomic Characteristics in Women with Bad Obstetric History, Kirkuk, Iraq.

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