Association between D-dimer and mortality in COVID-19 patients: a single center study from a Turkish hospital

Kilic, Mazlum; Hokenek, Ummahan Dalkilinc

doi:10.5603/demj.a2022.0039

Cited by 9 publications

(9 citation statements)

References 19 publications

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“…In some cases, thrombosis was found in asymptomatic forms of the disease [ 18 , 19 , 20 ]. In pediatric multisystem inflammatory syndrome, the laboratory findings suggest a procoagulant status with prominent increase of the D-dimer level, similar to patients with cytokine storm in acute COVID-19 infections [ 19 , 20 , 21 ]. Venous thrombosis is predominantly described, while reports of arterial thrombosis in children with COVID-19 are scarce.…”

Section: Discussionmentioning

confidence: 99%

Thrombosis in Multisystem Inflammatory Syndrome Associated with COVID-19 in Children: Retrospective Cohort Study Analysis and Review of the Literature

Bregel,

Efremova,

Kostyunin

et al. 2023

Biomedicines

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Background: The causative agent of the new coronavirus infection SARS-CoV-2 has unique properties causing hyperinflammatory syndrome and cytokine storm, as well as widespread endotheliitis and thrombotic microangiopathy, initially detected in the lungs of adult patients who died from a severe form of the disease. Venous and arterial thrombosis in adults were identified as common causes of severe complications and deaths in new coronavirus infections. There are very few reports of thrombotic events in children with COVID-19 in the literature. Methods: We conducted a retrospective analysis of the histories of 60 patients in the Irkutsk Regional Children’s Clinical Hospital from November 2020 to November 2022 with a MIS-C diagnosis established according to WHO criteria, of which 8 (13.3%) were diagnosed with venous and/or arterial thrombosis, confirmed by laboratory and ultrasound and/or X-ray methods. Results: The average age of children with thrombosis (Me) was 7.5 years (min 4 months, max 17 years), with a M:F ratio of 3.0. Venous thrombosis was detected in six of the eight patients, including in the deep veins of the lower extremities in four. Pulmonary embolism occurred in two (one of them was fatal), and cerebral venous sinus thrombosis and thrombosis of the branches of the upper and lower vena cava were found in one patient. Extensive bilateral stroke due to thrombosis of the large cerebral arteries occurred in two patients, including one in combination with distal gangrene. Secondary thrombotic renal microangiopathy took place in three of the eight patients. Among these three, atypical HUS was diagnosed in one case. Multiple thrombosis involving the venous and arterial bed was detected in four of the eight patients. High levels of D-dimer, thrombocytopenia, increased NT-proBNP, cerebral coma, and aseptic meningitis were the events most often associated with thrombosis. All patients received immunomodulatory therapy (immunoglobulin, dexamethasone/methylprednisolone), pathogenetic therapy for multiorgan failure, anticoagulant therapy with heparin/LMWH, and acetylsalicylic acid. Biologics were used in two patients. Conclusions: The main predictors of thrombosis in children with MIS-C were increased D-dimer, thrombocytopenia, hospitalization in the ICU, and noncardiogenic pulmonary edema. Thrombosis of the deep veins of the lower extremities, large cerebral arteries, and secondary thrombotic microangiopathy was common. There was a single death (12.5% of the eight patients), associated with PE.

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Section: Discussionmentioning

confidence: 99%

Thrombosis in Multisystem Inflammatory Syndrome Associated with COVID-19 in Children: Retrospective Cohort Study Analysis and Review of the Literature

Bregel,

Efremova,

Kostyunin

et al. 2023

Biomedicines

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“…Kilic and Dalkilinc Hokenek indicate that patients with high D-dimer levels had higher in-hospital mortality rates. It is worth emphasizing here that [1] Zhang et al [6] showed that D-dimer levels larger than 2.0 g/mL on admission (a fourfold rise) might successfully predict in-hospital mortality in COVID-19 patients, indicating that D-dimer could be an early and useful marker to enhance COVID-19 patient care.…”

mentioning

confidence: 86%

“…To the Editor, we read with great interest the article by Kilic and Dalkilinc Hokenek concerning to association between D-dimer levels and COVID-19 patients' mortality [1]. Since December 2019, a new coronavirus known as SARS-CoV-2 has produced a global outbreak of respiratory sickness known as coronavirus disease 2019 (COVID-19), which is still spreading rapidly.…”

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confidence: 99%

Biomarkers levels indicate COVID-19 severity and fatality

Nasheda,

Navolokina,

Hrytsan

2023

Disaster Emerg Med J

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“…It is well known that lymphocytes play a role in the infectious process. Furthermore, thrombocytes play an important role in the regulation of a number of inflammatory processes [13,14]. Changes in white blood cells, lymphocyte, and platelet counts are strongly associated with COVID-19 pneumonia [15].…”

Section: Introductionmentioning

confidence: 99%

Platelet-to-lymphocyte ratio as a prognostic biomarker for COVID-19 severity: a single center retrospective data analysis and systematic review with meta-analysis of 187 studies

Matuszewski,

Szarpak,

Pruc

et al. 2023

Disaster Emerg Med J

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Association between D-dimer and mortality in COVID-19 patients: a single center study from a Turkish hospital

Cited by 9 publications

References 19 publications

Thrombosis in Multisystem Inflammatory Syndrome Associated with COVID-19 in Children: Retrospective Cohort Study Analysis and Review of the Literature

Thrombosis in Multisystem Inflammatory Syndrome Associated with COVID-19 in Children: Retrospective Cohort Study Analysis and Review of the Literature

Biomarkers levels indicate COVID-19 severity and fatality

Platelet-to-lymphocyte ratio as a prognostic biomarker for COVID-19 severity: a single center retrospective data analysis and systematic review with meta-analysis of 187 studies

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