Association between daidzein intake and metabolic associated fatty liver disease: A cross-sectional study from NHANES 2017–2018

Yang, Zheng; Gong, Daoqing; He, Xinxiang; Huang, Fei; Sun, Yi; Hu, Qinming

doi:10.3389/fnut.2023.1113789

Cited by 11 publications

(6 citation statements)

References 68 publications

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“…In another study of ours, we found that with an increase in dietary intake of the antioxidant daidzein from soy, the prevalence of MAFLD and CAP values decreased. This suggests that dietary intake of antioxidants from soy may help reduce liver fat levels, although no significant reduction in LSM values in patients was observed 69 . RCS analysis exhibited a significant linear relationship between LSM and CDAI in males and a non-linear relationship in females after stratification by gender.…”

Section: Discussionmentioning

confidence: 94%

Association between the composite dietary antioxidant index and metabolic dysfunction-associated steatotic liver disease in adults: a cross-sectional study from NHANES 2017–2020

Yang,

Song,

et al. 2024

Sci Rep

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Metabolic dysfunction-associated steatotic liver disease (MASLD) has emerged as a predominant liver disease worldwide, lacking approved drugs for clinical intervention at present. The composite dietary antioxidant index (CDAI) is used to assess the anti-inflammatory properties of diets, with higher CDAI indicating greater exposure to antioxidants. Therefore, our study aimed to explore the relationship between CDAI and MASLD in order to identify potential therapeutic approaches. We collected data from 12,286 participants in the National Health and Nutrition Examination Survey (NHANES) database from 2017 to 2020 for analysis. The correlation between CDAI and MASLD status, controlled attenuation parameter (CAP), and liver stiffness measurement (LSM) was evaluated by adjusting for confounding variables using weighted binary logistic regression model, linear regression model, and restricted cubic spline (RCS) regression. The median CDAI in this study was − 0.3055 (interquartile range [IQR], − 2.299 to 2.290). The CDAI was higher in the population characterized by being young, female, higher income, absence of diabetes, and non-MASLD. After multivariable adjustment, the results of the weighted linear regression model suggested that higher CDAI may be associated with a decrease in CAP values; the results of the RCS regression model indicated significant non-linear relationships between MASLD status, CAP, LSM, and CDAI. The CDAI corresponding to the inflection points of the relationship curves between MASLD status, CAP, LSM, and CDAI were 0.349, 0.699, and 0.174, respectively. After further stratification by gender, we found that the relationship between MASLD status, CAP, and CDAI was significantly linear for females, whereas for males, it was non-linear, and the CDAI values corresponding to the inflection points in the curves for males were 1.325 and 0.985, respectively. We found that higher CDAI may be associated with decreased CAP values, particularly significant in females, suggesting that the intake of complex dietary antioxidants may ameliorate hepatic steatosis and reduce the occurrence of MASLD. Therefore, promoting dietary patterns rich in antioxidants may be an appropriate strategy to reduce the incidence of MASLD.

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Section: Discussionmentioning

confidence: 94%

Association between the composite dietary antioxidant index and metabolic dysfunction-associated steatotic liver disease in adults: a cross-sectional study from NHANES 2017–2020

Yang,

Song,

et al. 2024

Sci Rep

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“…The android-to-gynoid ratio is significantly associated with obesity-related diseases such as non-alcoholic fatty liver disease, insulin resistance, and postmenopausal osteoporosis. 15,28,29 WC has been proposed as a surrogate for indirectly assessing visceral fat gain and as an indicator of abdominal obesity in the diagnosis of MetS. 30 However, similar to BMI, WC by itself cannot quantify abdominal fat content and distribution.…”

Section: Discussionmentioning

confidence: 99%

Relationship between SIRI and android and gynoid fat related to obesity and cardiovascular risk: a cross-sectional study of NHANES 2017–2018

Zhang

2024

J Int Med Res

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Objective Inflammation has a crucial role in several metabolic diseases, such as obesity. The author aimed to investigate the relationship between the system inflammation response index (SIRI) and android fat composition and distribution. Methods Data for individuals aged 8–59 years, SIRI, android percent fat, and android-to-gynoid ratio from the 2017 to 2018 National Health and Nutrition Examination Survey were used. Weighted multiple linear regression and smooth curve fitting were used to test for linear and nonlinear associations. Additional subgroup analyses were performed. Threshold effect analysis was performed using a two-linear regression model. Results Multiple linear regression showed a positive correlation between SIRI and android percent fat (β 0.92, 95% confidence interval [CI] 0.25–1.59) and between SIRI and the android-to-gynoid ratio (β 0.01, 95% CI 0.00–0.03) in 3783 Americans aged 8–59 years. The results showed that the effect of factors, other than smoking status, on the relationship between SIRI and android percent fat and android-to-gynoid ratio was not significant. There was a nonlinear relationship between SIRI and both android percent fat and android-to-gynoid ratio. Conclusions Elevated SIRI levels were associated with an increased android percent fat and android-to-gynoid ratio. Larger prospective studies are needed to validate the findings.

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“…We collected variables including age (divided into 2-6, 7-11, and 12-17 years old) [ 16 ], gender, race, poverty-to-income ratio (PIR) (divided into <1, and ≥1) [ 17 ], household smoke exposure, family history of asthma, physical activity, sedentary time, pregnant smoking, breast feeding, low birth weight, BMI Z-score, and energy intake from the NHANES database.…”

Section: Methodsmentioning

confidence: 99%

Multivitamin consumption and childhood asthma: a cross-sectional study of the NHANES database

Zhang,

Xu,

et al. 2024

BMC Pediatr

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Background Dietary intakes of vitamins are associated with asthma. However, previous studies mainly explored the association between a single vitamin intake and asthma, which did not take the multivitamins into consideration. Herein, this study aims to explore the overall effect of dietary multivitamins consumption on childhood asthma. Methods Data of children and adolescents (aged 2-17 years old) were extracted from the National Health and Nutrition Examination Survey (NHANES) database in 2015-2018 in this cross-sectional study. Weighted univariate logistic regression analysis was used to screen covariates. The association between multivitamins (including vitamin A, C, D, E, B1, B2, B6, B12, K, niacin, folic acid, and choline) and childhood asthma was explored using univariate and multivariate logistic regression analyses. The evaluation indexes were odds ratio (OR) and 95% confidence interval (CI). We further introduced the Bayesian kernel machine regression (BKMR) to assess the joint effect of the twelve vitamins on childhood asthma, the impact of an individual vitamin as part of a vitamin mixture, and the potential interactions among different vitamins. Results Among 4,715 eligible children and adolescents, 487 (10.3%) had asthma. After adjusting for covariates including race, family history of asthma, pregnant smoking, BMI Z-score, energy intake, breast feeding, and low birth weight, we found that for each 1-unit increase in vitamin K consumption, the odds of childhood asthma decreased 0.99 (P=0.028). The overall effect analysis reported a trend of negative relationship between the multivitamins and childhood asthma, especially at the 75th percentile and over. According to the BKMR models, when other vitamins are fixed at the median level, the odds of childhood asthma increased along with the elevated vitamin D (VD) and vitamin B2 (VB2), whereas along with the depressed vitamin C (VC). In addition, no potential interaction has been found between every two vitamins of multivitamins on childhood asthma. Conclusion Among children and adolescents who have high-risk of asthma, it may be beneficial to increase dietary consumption of multivitamins. Our findings recommended that children and adolescents should increase the intake of VC-rich foods, whereas control the dietary consumption of VD and VB2 in daily life.

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Association between daidzein intake and metabolic associated fatty liver disease: A cross-sectional study from NHANES 2017–2018

Cited by 11 publications

References 68 publications

Association between the composite dietary antioxidant index and metabolic dysfunction-associated steatotic liver disease in adults: a cross-sectional study from NHANES 2017–2020

Association between the composite dietary antioxidant index and metabolic dysfunction-associated steatotic liver disease in adults: a cross-sectional study from NHANES 2017–2020

Relationship between SIRI and android and gynoid fat related to obesity and cardiovascular risk: a cross-sectional study of NHANES 2017–2018

Multivitamin consumption and childhood asthma: a cross-sectional study of the NHANES database

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