Association Between Degree of Gastritis and Malondialdehyde Level of Gastritis Patients at Adam Malik General Hospital Medan

Abstract

Background: The main pathogenesis of gastritis is inflammation which process can not be separated from the role of free radicals. Malondialdehyde (MDA) is a free radical biomarker and which increases in gastritis (p = 0.014; PR = 8.667;). There was a significant association between degree of neutrophil activity with high MDA level (p = 0.002; PR = 11.33;). There was a significant association between degree of atrophy with high level of MDA (p < 0.001; PR = 14;). There was a significant association between degree of intestinal metaplasia with high MDA level (p = 0.001; PR = 12.5;.Conclusion: There were significant associations between degree of lymphocyte infiltration, neutrophil activity, atrophy, and intestinal metaplasia with high level of MDA.

The Role of Folic Acid in Gastric Precancerous Lesion: A Literature Review

“…The presence of H. pylori significantly increases the risk of developing gastric atrophy, intestinal metaplasia, and dysplasia, which are key components of gastric precancerous lesions. [9][10][11][12] Certain ethnic groups have a higher risk of developing gastric precancerous lesions. For example, individuals of East Asian descent, including Chinese, Japanese, and Korean populations, have a higher incidence of these lesions compared to other ethnic groups.…”