The objective of this study was to evaluate potential risk factors, including the placement of dental implants, for the development of tooth cracks. A series of 212-patients, who were referred for endodontic treatment, were retrospectively screened, of which 72 (34%) patients had been diagnosed with 80-cracked teeth confirmed with an operating microscope. These patients had an average age of 53-years and were equally distributed between genders. Forty-one percent of the cracked teeth were diagnosed after the placement of dental implants, with an average of 3-implants per patient. Seventy percent of the cracks were diagnosed more than 1-year after implant loading. Implant placement was associated with higher odds of having multiple cracks (OR = 9.78, CI:2.320, 41.216)(p < 0.05). The proportion of cracked premolars was relatively high (30%), and most cracked teeth (79%) were vital and with a normal periapical diagnosis (86%). Most cracked teeth (71%) had an amalgam restoration, and teeth restored with amalgam were at a higher risk of having multiple cracks (p < 0.05). Clinicians should be aware of a common profile of endodontic patients with multiple cracks in a non-endodontically treated premolar, restored with an amalgam restoration, which was diagnosed with the cracks more than 1-year after reconstruction utilizing multiple implants. Excessive occlusal loads may lead to ensuing tooth fractures 1,2. Longitudinal tooth fractures include two sub-types: fractures that initiate from the root (vertical root fracture, VRF) 3 , and fractures initiating from the crown and extending apically (cracked teeth) 3-5. There are many potential risk factors for a cracked tooth that can be categorized into two sub-categories: natural origins (such as parafunctional habits, specific tooth anatomies, or certain patient ages) or iatrogenic origins (such as restorative procedures that caused excessive occlusal loads) 6,7. Although the precise occlusal relationship between dental implants and adjacent natural teeth is not fully clarified 2,8-11 , recently it has been claimed that the placement of dental implants may be a potential risk factor for the development of tooth cracks, either in endodontically 3 or in non-endodontically 12 treated teeth. A systematic review of the literature published in 2016 3 confirmed that this potential complication had not been reported prior to that review. Another recent study 12 presented a series of 18 cases of non-endodontically treated teeth that were diagnosed with cracks after the reconstruction of an implant-supported rehabilitation, and proposed that "the most common patient profile would be a woman over 50 years old, having a cracked mandibular premolar tooth, which was diagnosed more than 1 year after reconstruction based on multiple implants" 12. Nevertheless, due to the relatively small number of cases that were presented in these previous studies, the influence of potential risk factors on the development of tooth cracks following the placement of dental implants is yet unclear.