Association between Depression and Dry Eye Disease in an Elderly Population

Kim, Ki Woong; Han, Sang Beom; Han, Eugene; Woo, Se Joon; Lee, Jung Jae; Yoon, Jong Chul; Hyon, Joon Young

doi:10.1167/iovs.11-8050

Cited by 138 publications

(131 citation statements)

References 42 publications

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“…This agrees with previous studies in which DED had a negative effect on mental health (Mertzanis et al 2005;Galor et al 2011;Kim et al 2011;Le et al 2012;Li et al 2012;Wang et al 2012;Sakane et al 2013). The study on a non-clinic-based population in China showed lower QOL for mental health in subjects with DED (Le et al 2012).…”

Section: Discussionsupporting

confidence: 91%

“…The study on a non-clinic-based population in China showed lower QOL for mental health in subjects with DED (Le et al 2012). In a survey of the general population aged ≥ 65 years in Korea, the DED Group had a higher rate of depression compared with the Non-DED Group (Kim et al 2011). Wang et al (2012) demonstrated significantly higher prevalence of comorbidity in patients with depression and DED in Taiwan.…”

Section: Discussionmentioning

confidence: 89%

“…The impact of DED on QOL has been evaluated by several questionnaires (Nichols et al 2002;Mertzanis et al 2005;Kim et al 2011;Le et al 2012;Li et al 2012;Sakane et al 2013). For example, the visual function questionnaire such as the National Eye Institute's Visual Function Questionnaire 25 (NEI VFQ-25) has been used in many studies (Nichols et al 2002;Le et al 2012;Li et al 2012).…”

Section: Introductionmentioning

confidence: 99%

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Dry Eye Disease Is Associated with Deterioration of Mental Health in Male Japanese University Staff

Tounaka

Yuki

Kouyama

et al. 2014

Tohoku J. Exp. Med.

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Dry eye disease (DED) is defined as a multifactorial disease of the tears and ocular surface that results in symptoms of discomfort, visual disturbance, and tear-film instability, with potential damage to the ocular surface. It is thought to be associated with reduced quality of life (QOL). The aim of the present study was to investigate the effects of DED on health-related QOL in Japanese university sedentary office workers who are daily users of visual display terminal. In this study, 163 university staff (99 male and 64 female), aged 23-69 years, served as study subjects. Subjects were asked to answer the following three questions.(1) How often do your eyes feel dry? (2) How often do your eyes feel irritated? (3) Have you ever been diagnosed by a clinician as having dry eye syndrome? Sixty-eight subjects who answered "constantly," "often", or "sometimes" to both questions 1 and 2 were classified as the DED Group, and the remaining 95 were defined as the Non-DED Group. QOL was assessed by the SF-36 questionnaire, which consisted of 36 items to produce three summary scores, namely, mental, physical, and role/social component summary scores. For males, the DED Group had significantly lower scores than the Non-DED Group for mental component summary (MCS) (P = 0.005). In multiple regression analysis, MCS scores were adversely related to DED in males (P = 0.015). DED was associated with worsened QOL. DED should be regarded as a factor that can lead to deterioration of mental health.

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Section: Discussionsupporting

confidence: 91%

Section: Discussionmentioning

confidence: 89%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Dry Eye Disease Is Associated with Deterioration of Mental Health in Male Japanese University Staff

Tounaka

Yuki

Kouyama

et al. 2014

Tohoku J. Exp. Med.

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“…77 Others studies in Asian populations have described similar relationships between depression and dry eye. [78][79][80] Hypersensitivity to other stimuli and the development of diffuse pain states can also be seen with central sensitization, 74 and again these features have been described in dry eye. Data from the national VA database demonstrated that patients with chronic pain diagnoses (ICD-9 codes 338.29, 724.2, 724.5, 338.4, and 338.28) were 1.9 times more likely to carry a dry eye diagnosis compared with their counterparts without chronic pain (odds ratio (OR) 1.89, 95% confidence interval (CI) 1.88-1.90).…”

Section: Central Sensitization and Chronic Dry Eye Symptomsmentioning

confidence: 79%

Neuropathic ocular pain: an important yet underevaluated feature of dry eye

Galor

Levitt

Felix

et al. 2014

Eye

185

187

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Dry eye has gained recognition as a public health problem given its prevalence, morbidity, and cost implications. Dry eye can have a variety of symptoms including blurred vision, irritation, and ocular pain. Within dry eyeassociated ocular pain, some patients report transient pain whereas others complain of chronic pain. In this review, we will summarize the evidence that chronicity is more likely to occur in patients with dysfunction in their ocular sensory apparatus (ie, neuropathic ocular pain). Clinical evidence of dysfunction includes the presence of spontaneous dysesthesias, allodynia, hyperalgesia, and corneal nerve morphologic and functional abnormalities. Both peripheral and central sensitizations likely play a role in generating the noted clinical characteristics. We will further discuss how evaluating for neuropathic ocular pain may affect the treatment of dry eye-associated chronic pain.

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“…Although evaluation of tear volume is indispensable for dry eye diagnosis, precise measurement is difficult because of the tiny amount and transparency of tears. It is known that tear volume is affected by environmental, physical and psychological situations, such as humidity, wearing contact lenses, being engaged in VDT work and having mental stress [2,3]. At the clinical site, tear evaluation is usually performed by either schirmer's test or tear breakup time (BUT) measurement.…”

Section: Introductionmentioning

confidence: 99%

Feasibility Study of Smartphone-Based Tear Volume Measurement System

Okazaki¹,

Takenaga²,

Miyake³

et al. 2017

ICST Transactions on Ambient Systems

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Evaluation of tear volume is important for diagnosing dry eye disease. At the clinical site, dedicated devices such as slit lamp microscopy or Schirmer's test strip have been used to quantify tear volume by ophthalmologist. However, these devices have access only in medical office and therefore have limited availability for the public. Tear volume changes with environmental, physical or psychological situation. For that reason, measurement of tear volume regardless of location, time or circumstances can be beneficial. In this study, a tear volume measurement system based on the principle of meniscometry was developed and implemented on the smartphone, and its feasibility was evaluated. It was shown that tear meniscus radii of 22 human subjects were calculated to be mean 0.31 (SD 0.06) mm which was within the range of the previous study. The results suggested the feasibility of tear volume measurement system using the smartphone based on the principle of meniscometry as an IoT sensor.

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Association between Depression and Dry Eye Disease in an Elderly Population

Abstract: Depression was associated with DED symptoms in subjects with normal or mildly reduced tear production.

Cited by 138 publications

References 42 publications

Dry Eye Disease Is Associated with Deterioration of Mental Health in Male Japanese University Staff

Dry Eye Disease Is Associated with Deterioration of Mental Health in Male Japanese University Staff

Neuropathic ocular pain: an important yet underevaluated feature of dry eye

Feasibility Study of Smartphone-Based Tear Volume Measurement System

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