Association Between Depression and Mortality in Patients Receiving Long-term Dialysis: A Systematic Review and Meta-analysis

Farrokhi, Farhat; Abedi, Neda; Beyene, Joseph; Kurdyak, Paul; Jassal, Sarbjit V.

doi:10.1053/j.ajkd.2013.08.024

Cited by 262 publications

(221 citation statements)

References 88 publications

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“…A recent meta-analysis by Farrokhi et al, which included 31 studies and .67,000 patients on chronic dialysis, found that depression was independently associated with mortality (adjusted hazard ratio, 1.45; 95% CI, 1.27 to 1.65) (32). Three studies that performed sequential measurements of depression (two assessments in one study and semiannual assessments in two studies) also demonstrated an association of depression with mortality (hazard ratio, 1.66; 95% CI, 1.22 to Death or terminal withdrawal 62 (22) Data are presented as the n (%) or the median (interquartile range).…”

Section: Discussionmentioning

confidence: 99%

Associations of Depressive Symptoms and Pain with Dialysis Adherence, Health Resource Utilization, and Mortality in Patients Receiving Chronic Hemodialysis

Weisbord

Mor

Sevick

et al. 2014

Clinical Journal of the American Society of Nephrology

124

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Section: Discussionmentioning

confidence: 99%

Associations of Depressive Symptoms and Pain with Dialysis Adherence, Health Resource Utilization, and Mortality in Patients Receiving Chronic Hemodialysis

Weisbord

Mor

Sevick

et al. 2014

Clinical Journal of the American Society of Nephrology

124

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“…A recent meta-analysis by Farrokhi et al which included 31 studies and data of more than 67,000 patients undergoing dialysis found that the presence of depressive symptoms in such patients is associated with a 50% increase in the risk of mortality. 42 Notably, the method of measuring depression (self-rating scale vs interview or physician assessment) did not appear to modify the association between depression and mortality. 43 Of greater clinical relevance are persistent symptoms of depression.…”

Section: Consequences Of Depression and Anxiety On Treatment Outcomesmentioning

confidence: 93%

Anxiety and depression in patients with end-stage renal disease: impact and management challenges – a narrative review

Goh¹,

Griva²

2018

IJNRD

166

125

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Psychiatric disorders commonly co-exist with the diagnosis of chronic kidney disease (CKD). Research on depression and CKD has increased to a great extent. Multiple studies have demonstrated that depression is more prevalent in CKD and that end-stage renal disease is a robust risk factor for adverse outcomes such as hospitalization and mortality, yet these are often underdiagnosed or untreated. This review provides a selective overview on the prevalence rates of depression and anxiety in patients with CKD and across renal replacement therapies, the factors most consistently associated with symptoms of distress and their clinical implications. Finally, treatment and management strategies from relevant literature are appraised and discussed.

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“…9,16 It is associated with increased risk in mortality of 35% to 48%. 9,17,18 Depression in dialysis patients is also significantly associated with non-compliance to treatment, frequency of hospitalization and reduced quality of life. 16,19 In our study, we found that 51.9% of the patients suffered from mild depression and 6.1% with major depression which was significantly higher than in HD patients compared to the PD patients.…”

Section: Discussionmentioning

confidence: 99%

Stroke-free status and depression scores among Saudi dialysis patients

Sheayria¹,

Karkar

Almenawi

et al. 2015

Renal Failure

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Background: To assess the prevalence of stroke symptoms and depression among Saudi dialysis patients and related factors. Methods: This is a cross-sectional multicentre study of Saudi dialysis patients. Demographics, clinical and laboratory's data were collected. Freedom from stroke symptoms was assessed using the Questionnaire for Verifying Stroke-Free Status and depression using the Geriatric Depression Scale. Results: Five-hundred and forty-nine patients (77.3% response rate); 94.6% were receiving hemodialysis and 5.4% peritoneal dialysis were included in the study. Freedom from stroke was reported in 76.6% of patients, was higher in females (p ¼ 0.07), and was not affected by the presence of diabetes mellitus coronary artery disease or peripheral vascular disease. However, it was significantly lower in hypertensive patients (p ¼ 0.035) and was not affected by age, dialysis duration, Kt/V, albumin or hemoglobin levels. It was, however, more prevalent in the non-depressed patients compared to depressed patients (p ¼ 0.036). Mild and major depression scores were noted in 45.2% and 6.1%, respectively; the depression score being significantly higher in HD than in PD patients (6.3 ± 3.4 vs. 5.0 ± 3.2 p ¼ 0.049) but was not related to sex, employment, vascular access type, age, dialysis duration, Kt/V or serum albumin or hemoglobin levels. Conclusion: A quarter of the patients were not stroke symptom-free and these were more likely the depressed patients, in females, but significantly less in hypertensive patients. Almost half of the patients were depressed with 6.1% having major depression. The depression score was significantly higher in HD than in PD patients.

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Association Between Depression and Mortality in Patients Receiving Long-term Dialysis: A Systematic Review and Meta-analysis

Cited by 262 publications

References 88 publications

Associations of Depressive Symptoms and Pain with Dialysis Adherence, Health Resource Utilization, and Mortality in Patients Receiving Chronic Hemodialysis

Associations of Depressive Symptoms and Pain with Dialysis Adherence, Health Resource Utilization, and Mortality in Patients Receiving Chronic Hemodialysis

Anxiety and depression in patients with end-stage renal disease: impact and management challenges – a narrative review

Stroke-free status and depression scores among Saudi dialysis patients

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Association Between Depression and Mortality in Patients Receiving Long-term Dialysis: A Systematic Review and Meta-analysis

Cited by 262 publications

References 88 publications

Associations of Depressive Symptoms and Pain with Dialysis Adherence, Health Resource Utilization, and Mortality in Patients Receiving Chronic Hemodialysis

Associations of Depressive Symptoms and Pain with Dialysis Adherence, Health Resource Utilization, and Mortality in Patients Receiving Chronic Hemodialysis

Anxiety and depression in patients with end-stage renal disease: impact and management challenges &ndash; a narrative review

Stroke-free status and depression scores among Saudi dialysis patients

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Product

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Anxiety and depression in patients with end-stage renal disease: impact and management challenges – a narrative review