Association Between Depression Before Hematopoietic Stem Cell Transplantation and Posttransplant Survival: A Systematic Review and Meta-analysis

Guillaume, Matthieu; Endomba, Francky Teddy; Dornier, Alexandre; Chauvet-Gélinier, Jean-Christophe

doi:10.1016/j.jaclp.2022.12.006

Cited by 2 publications

(3 citation statements)

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“…We found "less than 5 years since HSCT" was also the susceptible factor of depression, the reason might be allo-HSCT recipients experienced higher symptom burden and worse physical functioning during and after the process of transplantation, so recipients' physical and psychologic condition declined rapidly, and gradually recovering toward pre-HSCT levels in the years following transplantation. 4,31 Our results showed the dose of ATG was negatively associated with depression. ATG has consistently demonstrated efficacies in GVHD prophylaxis.…”

Section: Discussionmentioning

confidence: 60%

“…Our study showed divorced/ widowed/ separated survivors were prone to depression, which is consistent with the common phenomenon: 30 There is a strong association between marital status and psychological disorder, and separated/divorced marital status were consistently associated with depression. We found “less than 5 years since HSCT” was also the susceptible factor of depression, the reason might be allo‐HSCT recipients experienced higher symptom burden and worse physical functioning during and after the process of transplantation, so recipients' physical and psychologic condition declined rapidly, and gradually recovering toward pre‐HSCT levels in the years following transplantation 4,31 . Our results showed the dose of ATG was negatively associated with depression.…”

Section: Discussionmentioning

confidence: 70%

“…Further investigation 3 revealed higher suicide rates among HSCT patients compared to the general population. Additionally, many allo‐HSCT survivors require psychotherapy, 4 , 5 and even those who do not meet diagnostic criteria may still experience distress.…”

Section: Introductionmentioning

confidence: 99%

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Psychological states and needs among post‐allogeneic hematopoietic stem cell transplantation survivors

Yanling,

Pu,

Duorong

et al. 2023

Cancer Medicine

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ObjectivesTo analyze psychological states and needs of patients after allogeneic hematopoietic stem cell transplantation (allo‐HSCT).MethodsQuestionnaires were sent to 101 allo‐HSCT survivors and 96 questionnaires were returned. The questionnaire covered several categories: (1) demographics and general information, (2) physical conditions, (3) psychologic status and sleep quality, (4) survivor's comments on transplantation, (5) demands and needs, (6) preferred forms and channels of information.ResultsDepression and poor sleep quality were major concerns troubling allo‐HSCT survivors. A notable discrepancy exists between clinically diagnosed depression (4.2%) and self‐ reported depression based on BDI‐13 (55.2%). Young adults (18–49 years old), chronic graft‐versus‐host disease, the ECOG performance score of 2–4, surviving within 5 years since HSCT, no or low dose of ATG used and being single were significantly associated with self‐reported depression. Based on the PSQI score, 75% of survivors experienced varying degrees of sleep quality impairment. Young adults, chronic GVHD and the ECOG score of 2–4 were significantly associated with worse sleep quality. The majority of patients reported unmet needs on physical and psychosocial aspects. Nutrition information was the most important topic, followed by disease treatments and fatigue. Differences in informational needs were found in the survivors according to age, time since HSCT and gender. WeChat public account and WeChat applet, mobile interactive platform and one‐to‐one conversation were the favorite channel for information.ConclusionsClinicians should establish more appropriate survivorship care plans focusing on survivors' psychologic states, demands and needs.

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Section: Discussionmentioning

confidence: 60%

Section: Discussionmentioning

confidence: 70%