2021
DOI: 10.1177/15347346211065527
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Association Between Dermcidin, Salusin-α, Salusin-β Molecules and Diabetic Foot Infections

Abstract: Dermcidin, salusin-α, and salusin-β are three recently discovered molecules that confer antimicrobial properties. The present study aims to investigate the association between dermcidin, salusin-α, and salusin-β in the etiopathology of patients with diabetic foot infection. The study included three groups: Group 1 - diabetic foot infection; Group 2 - diabetes without history of diabetic foot; and Group 3 – the control group. Plasma dermcidin, salusin-α, and salusin-β levels were compared across the groups. Med… Show more

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Cited by 2 publications
(3 citation statements)
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“…TNF-α is recognized as a crucial mediator in the immune response of macrophages against Brucella infection. TNF-α plays a crucial role in facilitating the recruitment of phagocytes to the site of infection and activating macrophages (Sağmak Tartar et al 2019 ). Additionally, TNF-α is of utmost significance in orchestrating immune responses against intracellular infections (Sağmak Tartar et al 2019 ).…”
Section: Discussionmentioning
confidence: 99%
See 1 more Smart Citation
“…TNF-α is recognized as a crucial mediator in the immune response of macrophages against Brucella infection. TNF-α plays a crucial role in facilitating the recruitment of phagocytes to the site of infection and activating macrophages (Sağmak Tartar et al 2019 ). Additionally, TNF-α is of utmost significance in orchestrating immune responses against intracellular infections (Sağmak Tartar et al 2019 ).…”
Section: Discussionmentioning
confidence: 99%
“…TNF-α plays a crucial role in facilitating the recruitment of phagocytes to the site of infection and activating macrophages (Sağmak Tartar et al 2019 ). Additionally, TNF-α is of utmost significance in orchestrating immune responses against intracellular infections (Sağmak Tartar et al 2019 ). This study’s findings indicate an increase in the production of proinflammatory cytokines, such as TNF-α, in both the L. lactis -pNZ8148-Usp45- Omp10 and IRIBA groups.…”
Section: Discussionmentioning
confidence: 99%
“…The dcd gene in humans encodes dermcidin, a two-region anionic AMP produced and secreted by eccrine sweat glands and transported to the skin surface [ 116 , 292 ]. The N-terminal peptide is involved with neuronal cell survival in response to oxidative stress [ 116 ]; meanwhile, the C-terminal fragment shows anti- Acinetobacter activity [ 293 ]. With a net charge of -2, DCD-1L can interact with negatively charged bacterial phospholipids.…”
Section: Antimicrobial Peptidesmentioning
confidence: 99%