Association between diabetes complications and leukocyte counts in Iranian patients

Moradi, Sedighe; Kerman, Scott Reza Jafarian; Rohani, Farzaneh; Salari, Fereshteh

doi:10.2147/jir.s26917

Cited by 44 publications

(33 citation statements)

References 30 publications

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“…In addition, in an effort to isolate the primary influence of WBC, we studied adults free of other cardiometabolic risk factors that have been shown to influence WBC and endothelin-1 system activity such as hypertension 21 and type 2 diabetes. 26,27 Although the plasma concentrations of CRP were slightly, but not significantly, higher in the WBC group, we do not believe that these higher CRP concentrations influenced our findings, and in turn, the interpretation the data. Indeed, in the present study we observed no relation between CRP and either WBC or the FBF responses to ET-1 or BQ-123.…”

Section: Discussioncontrasting

confidence: 60%

White blood cell count and endothelin-1 vasoconstrictor tone in middle-aged and older adults

Diehl¹,

Weil²,

Greiner³

et al. 2012

ARTRES

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Background Higher white blood cell (WBC) count is associated with impaired endothelium-dependent vasodilation. However, the influence of higher WBC count on endothelin (ET)-1 vasoconstrictor activity is currently unknown. We tested the hypothesis that adults with elevated WBC count demonstrate enhanced ET-1 system activity. Methods Thirty-four healthy adults were studied: 17 with WBC count < 5.0 × 109 cells/L (lower WBC; 9M/8F; age: 53 ± 2 yr) and 17 with WBC count > 5.0 × 109 cells/L (higher WBC; 10M/7F; 54 ± 3 yr). Forearm blood flow (FBF) responses to intra-brachial infusion of ET-1 (5 pmol/min for 20 min) and selective ETA receptor blockade (BQ-123; 100 nmol/min for 60 min) were measured by venous occlusion plethysmography. Results The vasoconstrictor response to ET-1 was significantly blunted (∼60%) in the higher WBC group versus the lower WBC group. The FBF responses to selective ETA receptor blockade were also significantly different (P < 0.05) between the groups. In the lower WBC group, resting FBF increased marginally (∼5%) to BQ-123, whereas the increase in FBF to BQ-123 was significantly greater (∼15%) in higher WBC group. Furthermore, there was a significant relation between WBC count and FBF response to ET-1 (r = −0.43) and BQ-123 (r = 0.41). Conclusions Relative elevations in WBC count in middle-aged and older adults, independent of adiposity and other cardiometabolic risk factors, are associated with enhanced ET-1-mediated vasoconstrictor tone. Elevated ET-1 system activity may be a mechanism linking higher WBC count with increased cardiovascular risk.

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Section: Discussioncontrasting

confidence: 60%

White blood cell count and endothelin-1 vasoconstrictor tone in middle-aged and older adults

Diehl¹,

Weil²,

Greiner³

et al. 2012

ARTRES

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“…To date, numerous studies have shown that high total leukocyte count at baseline is associated with later development of type 2 diabetes and poor health outcomes in older adults [17,24,29,32,45,48]. Furthermore, many studies have demonstrated that higher total leukocyte count is linked to metabolic syndrome, but the association between differential leukocyte count and this chronic condition is still unclear.…”

Section: Leukocyte Count and Insulin Resistancementioning

confidence: 99%

Elevated leukocyte count as a harbinger of systemic inflammation, disease progression, and poor prognosis: a review

Chmielewski

Strzelec

2018

Folia Morphol

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Total leukocyte count increases significantly in response to infection, trauma, inflammation, and certain diseases. Factors affecting leukocyte count in healthy adults include sex, hormonal milieu, genetic inheritance, stress level, diet, nutrition, and lifestyle (e.g. tobacco-induced inflammatory changes, chronic psychological stress, etc.). To date, numerous studies have reported that high but normal leukocyte counts at baseline predict increased cardiovascular and noncardiovascular mortality in older adults. Recent findings suggest that elevated leukocyte count within the normal range, but especially neutrophil and monocyte counts, may be a harbinger of increased systemic inflammation and subclinical disease. Moreover, elderly people who tend to have high but normal leukocyte counts are at greater risk of cancer, cardiovascular disease, type 2 diabetes, some other age-related conditions, and they also have increased all-cause mortality. These results indicate that strong and reliable inflammatory markers, such as leukocyte count, may reflect the rate of ageing and therefore can predict long-term survival in the elderly. Remarkably, leukocyte count correlates positively with genuine markers of systemic inflammation like C-reactive protein and interleukin 6. Interestingly, some authors conclude that leukocyte counts have a stronger prognostic ability with regard to total and cardiovascular mortality than total cholesterol or low-density lipoproteins. The fact that these inflammatory markers are clinically useful predictors of long-term survival in the elderly is quite remarkable as these blood parameters are included in routine medical check-ups. Therefore, they can be used as simple and reliable morphological indicators of chronic systemic inflammation, disease progression, and poor prognosis, especially among individuals who are likely to develop age-related conditions. Nevertheless, the pathomechanism that links elevated but normal leukocyte counts to increased mortality remains poorly understood. This review summarises the most important findings on the links between leukocyte count, chronic systemic inflammation, and health outcomes in older adults. (Folia Morphol 2018; 77, 2: 171-178).

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“…There are studies indicating that an elevated WBC count, even within the normal range, is associated with both macro- and microvascular complications in type 2 diabetes 6. Higher WBC counts may be associated with the development of retinopathy, albuminuria, and peripheral arterial disease 7-9. Previous studies have paid much attention to proinflammatory cytokines but little to the routine and reliable WBC count.…”

Section: Introductionmentioning

confidence: 99%

Correlation between Peripheral White Blood Cell Counts and Hyperglycemic Emergencies

Wei¹,

Wu²,

Ma³

et al. 2013

Int. J. Med. Sci.

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Objective: To determine the correlation between differential leukocyte counts and hyperglycemic emergencies.Methods: Fifty patients with diabetic ketoacidosis (DKA), 50 patients with diabetic ketosis (DK), 50 non-DK diabetic patients with stable glycemic control, and 50 normal controls were enrolled. Their total and differential leukocyte counts were measured and evaluated at admission and after treatment.Results: The patients with DKA and DK had higher plasma glucose levels (20.84±6.73 mmol/L, 15.55±2.6 mmol/L, respectively) and more median leukocytes (13325/mm3 and 6595/mm3, respectively) and median neutrophils (11124 /mm3 and 4125/mm3, respectively) but fewer median eosinophils (28/mm3 and 72/mm3, respectively) compared to non-DK and control groups (all p < 0.05). Acute infection increased the elevating extent. The median leukocyte counts in DK and non-DK patients (6595/mm3 and 6008/mm3, respectively) were within the normal range. The counts of total leukocytes and neutrophils were significantly higher but eosinophils lower in severe DKA cases than in mild/moderate cases (p < 0.05). When the DKA and DK and infection resolved, total leukocytes and neutrophils fell, but eosinophils increased. The counts of total leukocytes, neutrophils, and monocytes were negatively correlated with arterial pH levels (r = -0.515, r = -0.510, r = -0.517, all p < 0.001, respectively) and positively correlated with plasma glucose levels (r = 0.722, r = 0.733, r = 0.632, all p < 0.05, respectively) in DKA patients. The arterial pH level was the most significant factor affecting total leukocytes in DKA (β = 0.467, p = 0.003). The diagnosis analysis showed that higher total leukocyte and neutrophil counts and lower eosinophil counts had a significant ability to reflect the presence of hyperglycemic emergencies.Conclusion: More total leukocytes and neutrophils but fewer eosinophils was significantly correlated with DKA and DK. Leukocyte counts can add valuable information to reflect the presence of hyperglycemic crisis and acute infection.

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Association between diabetes complications and leukocyte counts in Iranian patients

Cited by 44 publications

References 30 publications

White blood cell count and endothelin-1 vasoconstrictor tone in middle-aged and older adults

White blood cell count and endothelin-1 vasoconstrictor tone in middle-aged and older adults

Elevated leukocyte count as a harbinger of systemic inflammation, disease progression, and poor prognosis: a review

Correlation between Peripheral White Blood Cell Counts and Hyperglycemic Emergencies

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