Association between diabetes mellitus and central arterial stiffness in elderly patients with systemic arterial hypertension

Galvão, Romário Divino Vilarinho; Pereira, Cristiane de Sousa; Freitas, Ercilhana Gonçalves Batista; Lima, Damianna R A R Teixeira; Santos, Walkiria Almeida Martins; Souza, Denis Fabiano de; Nomelini, Quintiliano Siqueira Schroden; Ferreira-Filho, Sebastião Rodrigues

doi:10.1080/10641963.2020.1783547

Cited by 5 publications

(4 citation statements)

References 31 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…As cerebral autoregulation is maintained by vascular dilation and constriction, the importance of vascular properties which are regulated by cerebrovascular endothelium, perivascular nerves, and vascular smooth muscle cells in determining cerebral autoregulation was suggested 14 . Univariate analysis in our study has shown that prevalence of diabetes, ischemic heart disease, and use of calcium channel blockers were associated with LLA before or during CPB, which are factors closely associated with aortic stiffness and endothelial function 15,16 …”

Section: Discussionmentioning

confidence: 56%

“…14 Univariate analysis in our study has shown that prevalence of diabetes, ischemic heart disease, and use of calcium channel blockers were associated with LLA before or during CPB, which are factors closely associated with aortic stiffness and endothelial function. 15,16 Similar to ambulatory arterial stiffness, baPWV is also a measure of aortic stiffness which is familiar to clinicians as it can easily be performed in the out-patient clinic. Furthermore, its clinical application in an evaluation of risk for cerebrovascular disease has also been reported in which every 1SD increase in baPWV was associated with 1.19-fold increase in the risk of cerebrovascular disease.…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Relationship between endothelial function and vascular stiffness on lower limit of cerebral autoregulation in patients undergoing cardiovascular surgery

et al. 2020

View full text Add to dashboard Cite

Hemodynamic management based on cerebral autoregulation range is a possible strategy for preserving major organ perfusion during cardiovascular surgery. The purpose of this study was to evaluate the relation of vascular properties with lower limit of cerebral autoregulation (LLA). LLA was monitored in 66 patients undergoing cardiovascular surgery using near-infrared spectroscopy. To determine the clinical importance of LLA monitoring, association of blood pressure excursions below LLA and acute kidney injury (AKI) was evaluated. Flow-mediated dilation (FMD) and pulse wave velocity (PWV) were measured for the evaluation of endothelial function and aortic stiffness. Variables associated with LLA were evaluated. Excluding patients on hemodialysis, there were 15 patients (25.9%) who developed AKI. Blood pressure excursions below LLA were higher in patients who developed AKI (4.55 mm Hg × hr

show abstract

Section: Discussionmentioning

confidence: 56%

Section: Discussionmentioning

confidence: 99%

Relationship between endothelial function and vascular stiffness on lower limit of cerebral autoregulation in patients undergoing cardiovascular surgery

et al. 2020

View full text Add to dashboard Cite

show abstract

“…Notably, in the present study, the DCCB users aged ≥65 years had the lowest advanced CKD and ESRD risks, suggesting DCCB safety and effectiveness in elderly DM patients with CKD. Elderly patients, particularly those with DM and CKD, may glean more benefits from DCCB use because advanced age is associated with greater arterial stiffness ( Scuteri et al, 2018 ; Galvão et al, 2020 ). Future studies investigating the renal benefits of DCCBs for elderly patients with DM are warranted.…”

Section: Discussionmentioning

confidence: 99%

Chronic Kidney Disease Progression Risk in Patients With Diabetes Mellitus Using Dihydropyridine Calcium Channel Blockers: A Nationwide, Population-Based, Propensity Score Matching Cohort Study

Lin

et al. 2022

Front. Pharmacol.

View full text Add to dashboard Cite

Background: Whether diabetes mellitus (DM) patients with chronic kidney disease (CKD) can glean individual renal benefit from dihydropyridine calcium channel blockers (DCCBs) remains to be determined. We conducted a nationwide, population-based, propensity score matching cohort study to examine the effect of DCCBs on CKD progression in DM patients with CKD.Methods: One million individuals were randomly sampled from Taiwan’s National Health Insurance Research Database. The study cohort consisted of DM patients with CKD who used DCCBs. The comparison cohort was propensity-matched for demographic characteristics and comorbidities. The endpoint was advanced CKD or end-stage renal disease (ESRD). The Cox proportional hazards model was used to calculate the risks.Results: In total, 9,761 DCCB users were compared with DCCB nonusers at a ratio of 1:1. DCCB users had lower risk of advanced CKD and ESRD than nonusers—with adjusted hazard ratio [aHR; 95% confidence interval (CI)] of 0.64 (0.53–0.78) and 0.59 (95% CI, 0.50–0.71) for advanced CKD and ESRD, respectively. DCCB users aged ≥65 years had the lowest incidence rates of advanced CKD and ESRD—with aHR (95% CI) of 0.47 (0.34–0.65) and 0.48 (0.35–0.65) for advanced CKD and ESRD, respectively. Finally, cumulative DCCB use for >1,100 days was associated with the lowest advanced CKD and ESRD risks [(aHR, 0.29 (95% CI, 0.19–0.44)].Conclusion: DM patients with CKD who used DCCBs had lower risk of progression to advanced CKD and ESRD than nonusers did.

show abstract

“…Вступ. Відомо, що артеріальна гіпертензія (АГ), особливо з коморбідними цукровим діабетом (ЦД), який суттєво збільшує ризик виникнення мікро-і макросудинних ускладнень, гіперхолестеролемією, ішемічною хворобою серця (ІХС), хронічною серцевою недостатністю (ХСН), є основним чинником ризику виникнення хронічних хвороб, кардіоваскулярної смертності й підвищеної інвалідизації, а також причиною значних медичних, соціальних проблем та економічних витрат [4,6,7,9,12,17,26,28,29,33].…”

unclassified

About the Problem of Arterial Hypertension as a Risk Factor in the COVID-19 Pandemic Conditions and its Treatment (Literature Review)

Дунаєва¹,

Kravchun²

2021

Lʹviv. klin. visn.

View full text Add to dashboard Cite

Context. In a pandemic caused by a coronavirus infection, a special risk group are the patients with cardiovascular disease, hypertension and diabetes mellitus in particular, which are the most common risk groups among the general population. The spread of coronavirus disease is particularly dangerous in terms of decompensation of chronic complications, specific damage to the cardiovascular system, especially in cases of severe infection and high risk of adverse outcomes in the above cohort of patients. The combination of coronavirus disease and cardiovascular disease poses additional difficulties in diagnosing, identifying, and prescribing appropriate therapy, including antihypertensive therapy. Therefore, it is important to address the possible risks and complications in people with hypertension and diabetes mellitus in the conditions of coronavirus disease COVID-19 and the features of the antihypertensive therapy prescription. Objective. To investigate the peculiarities of treatment of patients with arterial hypertension in the context of the COVID-19 pandemic, to analyze possible risks and complications based on the results of studying the literature. Materials and methods. Content analysis, methods of systemic and comparative results, as well as bibliosemantic evaluation of current research in the literature on the prescription of antihypertensive therapy in patients with hypertension and diabetes in the conditions of coronavirus COVID-19 were used. Sources of information were searched in scientometric medical databases, namely PubMedNCBI, Medline, Web of Science and Google Scholar, etc. by keywords: diabetes, hypertension, antihypertensive therapy, COVID-19, complications, cardiovascular risk. 174 scientific works in English, Ukrainian and Russian were analyzed and sources were selected, which contain questions about the risks of patients with hypertension and diabetes in the conditions of coronavirus disease, including those related to the appointment of antihypertensive therapy. Results. RAAS inhibitors, which provide better blood pressure control, may partially help to maintain the immune system imbalance in hypertension. In patients with hypertension during a viral infection, blood pressure levels and cardiovascular risk should be monitored. Conclusions. Constant monitoring of hemodynamic parameters, ECG and ECHO-CG – should be under the control according to the indications. The association of RAAS blockers (ACE inhibitors and ARBs) with an increased risk of infection in patients and worsening of COVID-19 has not been established so far, so patients with CVD should continue to take them. Patients who have survived coronavirus disease should be included in the medical rehabilitation programs for faster and better recovery of various systems, primarily respiratory and cardiovascular, as well as to improve quality of life and reduce the risk of disability.

show abstract

Association between diabetes mellitus and central arterial stiffness in elderly patients with systemic arterial hypertension

Cited by 5 publications

References 31 publications

Relationship between endothelial function and vascular stiffness on lower limit of cerebral autoregulation in patients undergoing cardiovascular surgery

Relationship between endothelial function and vascular stiffness on lower limit of cerebral autoregulation in patients undergoing cardiovascular surgery

Chronic Kidney Disease Progression Risk in Patients With Diabetes Mellitus Using Dihydropyridine Calcium Channel Blockers: A Nationwide, Population-Based, Propensity Score Matching Cohort Study

About the Problem of Arterial Hypertension as a Risk Factor in the COVID-19 Pandemic Conditions and its Treatment (Literature Review)

Contact Info

Product

Resources

About