Association between diabetes status and breast cancer in US adults: findings from the US National Health and Nutrition Examination Survey

Abstract

ObjectivesThe aim of this study was to investigate the association between diabetes status and the risk of breast cancer among adult Americans, exploring the impact of BMI, age, and race on this relationship.MethodsA cross-sectional analysis of 8,249 individuals from the National Health and Nutrition Examination Survey (NHANES) was conducted. Diabetes was categorized as type 2 diabetes and prediabetes, with both conditions diagnosed according to the ADA 2014 guidelines. The association between diabetes status and breast cancer risk was explored using multiple logistic regression analysis.ResultsPatients with diabetes had higher odds of breast cancer (OR: 1.51; 95% CI 1.00 to 2.28), Using the two-piecewise linear regression model, it was observed that there is a threshold effect in the risk of breast cancer occurrence at the age of 52 years. Specifically, the risk of breast cancer is relatively low before the age of 52 but increases significantly after this age.ConclusionsThis study identified a significant association between diabetes status and breast cancer risk among adult Americans. We also found a threshold effect in breast cancer occurrence at the age of 52. Age was significantly associated with breast cancer risk in both Non-Hispanic White and Non-Hispanic Black individuals. These findings underscore the importance of diabetes management, maintaining a healthy BMI, and age-related risk considerations in reducing breast cancer risk.

In hospital outcomes of autologous and implant‐based breast reconstruction in patients with diabetes mellitus: A population‐based study of 2015–2020 national inpatient sample

“…Patients with DM are at an increased risk of developing breast cancer. 15,16 However, the representation of DM patients in breast reconstruction postmastectomy is disproportionately low (ABR 7.68%; IBR 7.38%) compared to their prevalence in the general population (11.6%). 17 DM is linked to a reduced likelihood of undergoing mastectomy and a lower probability of receiving breast reconstruction postmastectomy.…”

Diabetes Mellitus and Thyroid Cancers: Risky Correlation, Underlying Mechanisms and Clinical Prevention

“…Notably, the occurrence and development of breast, gastric, colorectal, and pancreatic cancers are closely associated with diabetes. [7][8][9][10] Through an examination of the clinical data from patients with diabetes and thyroid cancer, we found that the risk of thyroid cancer was significantly increased in patients with diabetes. With the increasing incidence of thyroid cancer, it is necessary to analyze the correlation between thyroid cancer and diabetes to provide valuable insights for the prevention and improving prognosis of thyroid cancer.…”