Association between dietary fat intake and bone mineral density in Korean adults: data from Korea National Health and Nutrition Examination Survey IV (2008∼2009)

Kwon, Young‐Min; Kim, G. W.; Yim, Hyeon Woo; Paek, Yu Jin; Lee, K.-S.

doi:10.1007/s00198-014-2977-x

Cited by 24 publications

(14 citation statements)

References 31 publications

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“…These findings may not directly correlate with our findings as the age groups or BMD measurements differed slightly from the current study, but they highlight the scientific interest and often times conflicting results of how vitamin D and magnesium may potentially contribute to bone mass accrual. The current assumption on the potentially negative role of high daily fat intake in BMD is more consistent [30, 31], and this is reflected by our findings in the adolescent group (16- to 19-year-olds). However, most of the available studies on daily fat intakes were performed in adults or even postmenopausal women, and a translation to adolescents requires further investigation.…”

Section: Discussionsupporting

confidence: 81%

Nutritional factors associated with femoral neck bone mineral density in children and adolescents

Gou

Tseng

Wang

et al. 2019

BMC Musculoskelet Disord

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BackgroundNutritional factors including vitamin D, magnesium, and fat are known to affect bone mineral accrual. This study aimed to evaluate associations between dietary nutrient intakes (both macronutrients and micronutrients) and bone mineral density (BMD) in children and adolescents.MethodsData for this cross-sectional, population-based study were derived from the National Health and Nutrition Examination Survey (NHANES). Participants aged from 8 to 19 years were included. The primary outcome was femoral neck BMD.ResultsMultivariate analyses revealed that for participants aged 8 to 11, daily sodium intake was significantly and positively associated with femoral neck BMD (B = 0.9 × 10− 5, p = 0.031); in particular, subgroup analyses by sex found that in male participants aged 8–11, daily total cholesterol intake (B = 5.3 × 10− 5, p = 0.030) and calcium intake (B = − 2.0 × 10− 5, p < 0.05) were significantly associated with femoral neck BMD in a positive and negative manner, respectively, but neither were observed in female participants of this age group. In contrast, daily intakes of vitamin D and magnesium were significantly and positively associated with femoral neck BMD in female participants aged 8–11 (B = 246.8 × 10− 5 and 16.3 × 10− 5, p = 0.017 and 0.033, respectively). For participants aged 16 to 19, daily total fat intake was significantly and negatively associated with femoral neck BMD (B = − 58 × 10− 5, p = 0.048); further stratification by sex found that magnesium and sodium intakes were significantly and positively associated with femoral neck BMD only in females of this age group (B = 26.9 × 10− 5 and 2.1 × 10− 5, respectively; both p < 0.05). However, no significant associations between daily nutrient intakes and femoral neck BMD were identified in participants aged 12–15 before or after subgroup stratification.ConclusionThe study found that associations of specific nutrition-related variables with BMD of the femoral neck is dependent upon age and gender.

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Section: Discussionsupporting

confidence: 81%

Nutritional factors associated with femoral neck bone mineral density in children and adolescents

Gou

Tseng

Wang

et al. 2019

BMC Musculoskelet Disord

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“…In addition, studies suggest that HFD that are typically rich in saturated fatty acids (SFAs), negatively affect bone mineral density (BMD) during growth in rat studies [6]. This is supported by observational studies in adult humans showing that a high fat intake is negatively associated with BMD [7, 8]. Conversely, we and others found that dietary fat intake was positively related to Ca absorption in both human and rodent studies [9-11].…”

Section: Introductionmentioning

confidence: 99%

High fat diet enriched with saturated, but not monounsaturated fatty acids adversely affects femur, and both diets increase calcium absorption in older female mice

et al. 2016

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Diet induced obesity has been shown to reduce bone mineral density (BMD) and Ca absorption. However, previous experiments have not examined the effect of high fat diet (HFD) in the absence of obesity or addressed the type of dietary fatty acids. The primary objective of this study was to determine the effects of different types of high fat feeding, without obesity, on fractional calcium absorption (FCA) and bone health. It was hypothesized that dietary fat would increase FCA and reduce BMD. Mature 8-month-old female C57BL/6J mice were fed one of three diets: a HFD (45% fat) enriched either with monounsaturated fatty acids (MUFAs) or with saturated fatty acids (SFAs), and a normal fat diet (NFD; 10% fat). Food consumption was controlled to achieve a similar body weight gain in all groups. After 8wk, total body bone mineral content and BMD as well as femur total and cortical volumetric BMD were lower in SFA compared with NFD groups (P < 0.05). In contrast, femoral trabecular bone was not affected by the SFAs, whereas MUFAs increased trabecular volume fraction and thickness. The rise over time in FCA was greater in mice fed HFD than NFD and final FCA was higher with HFD (P < 0.05). Intestinal calbindin-D9k gene and hepatic cytochrome P450 2r1 protein levels were higher with the MUFA than the NFD diet (P < 0.05). In conclusion, HFDs elevated FCA overtime; however, an adverse effect of HFD on bone was only observed in the SFA group, while MUFAs show neutral or beneficial effects.

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“…In contrast to our expectations, we did not find differences between the fortification of solely calcium citrate and fortification of calcium citrate and vitamin D. This lack of difference is likely due to the high amount of vitamin D already present in the standard diets used for mice, masking the added effect of extra vitamin D. Whether these findings are relevant to the human setting remains to be confirmed. Often diet compliance in humans is poor [36,37] and remaining on HFD after surgery may indeed compromise calcium absorption [38][39][40], thus leading to SHPT. Nonetheless, also in humans there are reports that bone loss after bariatric surgery occurs even though PTH remains within normal range [10,[17][18][19][20].…”

Section: Discussionmentioning

confidence: 99%

The curious fate of bone following bariatric surgery: bone effects of sleeve gastrectomy (SG) and Roux-en-Y gastric bypass (RYGB) in mice

et al. 2020

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Background Bone loss and increased fracture risk following bariatric surgery has been reported. We investigated whether the two most commonly performed surgeries, sleeve gastrectomy (SG) and Roux-en-Y gastric bypass (RYGB), lead to bone loss. In addition, we examined whether fortification of the diet with calcium citrate prevents bone loss. Methods We used mouse models for SG and RYGB and compared bone loss with a group of sham mice with similar weight loss. All groups were switched at the time of surgery to a low-fat diet (LFD). We also examined whether fortification of the diet with calcium citrate and vitamin D was able to prevent bone loss. Results At 2 weeks we observed no major bone effects. However, at 8 weeks, both trabecular and cortical bone were lost to the same extent after SG and RYGB, despite increased calcium absorption and adequate serum levels of calcium, vitamin D, and parathyroid hormone (PTH). Diet fortification with calcium citrate and vitamin D was able to partially prevent bone loss. Conclusions Both SG and RYGB lead to excess bone loss, despite intestinal adaptations to increase calcium absorption. Fortifying the diet with calcium citrate and vitamin D partly prevented the observed bone loss. This finding emphasizes the importance of nutritional support strategies after bariatric surgery, but also affirms that the exact mechanisms leading to bone loss after bariatric surgery remain elusive and thus warrant further research.

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Association between dietary fat intake and bone mineral density in Korean adults: data from Korea National Health and Nutrition Examination Survey IV (2008∼2009)

Cited by 24 publications

References 31 publications

Nutritional factors associated with femoral neck bone mineral density in children and adolescents

Nutritional factors associated with femoral neck bone mineral density in children and adolescents

High fat diet enriched with saturated, but not monounsaturated fatty acids adversely affects femur, and both diets increase calcium absorption in older female mice

The curious fate of bone following bariatric surgery: bone effects of sleeve gastrectomy (SG) and Roux-en-Y gastric bypass (RYGB) in mice

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