Association Between Dietary Fatty Acid Pattern and Risk of Oral Cancer

Fan, Yi; Qiu, Yu; Chen, Qing; Wang, Sijie; Wang, Yaping; Li, Yanni; Weng, Yanfeng; Qian, Jiawen; Chen, Fa; Wang, Jing; Shi, Bin; Pan, Lizhen; Lin, Lisong; He, Baochang; Liu, Fengqiong

doi:10.3389/fnut.2022.864098

Cited by 7 publications

(10 citation statements)

References 49 publications

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“…However, research exploring the link between dietary patterns rich in Saturated Fatty Acids (SFAs) and cancer risk remains limited. The ones that have been reported to date have investigated dietary patterns with high SFA content in relation to specific cancers, and all such studies have reported that this dietary pattern is positively associated with the risk of the concerned specific cancers [ 18 , 19 ]. Consequently, an increasing number of patients, clinicians, and researchers are accepting the possibility of preventing the onset of cancer or improving the prognosis of cancer through the implementation of “anticancer” dietary interventions.…”

Section: Discussionmentioning

confidence: 99%

“…In addition, within the scope of this research, just one study reported the association of total SFAs with bladder cancer, endometrial cancer, esophageal squamous cell carcinoma, hepatocellular carcinoma, non-Hodgkin’s lymphoma, oral and nasopharyngeal carcinoma, oral cancer, and renal cell carcinoma [ 18 , 34 , 35 , 39 , 42 , 43 , 45 , 54 ]. The conclusions drawn from the data in these studies could be used as a reference, although further research is warranted to verify the findings.…”

Section: Discussionmentioning

confidence: 99%

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Association of saturated fatty acids with cancer risk: a systematic review and meta-analysis

Mei,

Qian,

Hou

et al. 2024

Lipids Health Dis

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Objective Extensive research has explored the link between saturated fatty acids (SFAs) and cardiovascular diseases, alongside other biological dysfunctions. Yet, their association with cancer risk remains a topic of debate among scholars. The present study aimed to elucidate this association through a robust meta-analysis. Methods PubMed, Embase, Cochrane Library, and Web of Science databases were searched systematically to identify relevant studies published until December 2023. The Newcastle-Ottawa Scale was used as the primary metric for evaluating the quality of the included studies. Further, fixed- or random-effects models were adopted to determine the ORs and the associated confidence intervals using the Stata15.1 software. The subsequent subgroup analysis revealed the source of detection and the cancer types, accompanied by sensitivity analyses and publication bias evaluations. Results The meta-analysis incorporated 55 studies, comprising 38 case-control studies and 17 cohort studies. It revealed a significant positive correlation between elevated levels of total SFAs and the cancer risk (OR of 1.294; 95% CI: 1.182–1.416; P-value less than 0.001). Moreover, elevated levels of C14:0, C16:0, and C18:0 were implicated in the augmentation of the risk of cancer. However, no statistically significant correlation of the risk of cancer was observed with the elevated levels of C4:0, C6:0, C8:0, C10:0, C12:0, C15:0, C17:0, C20:0, C22:0, and C24:0. Subgroup analysis showed a significant relationship between excessive dietary SFA intake, elevated blood SFA levels, and heightened cancer risk. Increased total SFA levels correlated with higher risks of breast, prostate, and colorectal cancers, but not with lung, pancreatic, ovarian, or stomach cancers. Conclusion High total SFA levels were correlated with an increased cancer risk, particularly affecting breast, prostate, and colorectal cancers. Higher levels of specific SFA subtypes (C14:0, C16:0, and C18:0) are also linked to an increased cancer risk. The findings of the present study would assist in providing dietary recommendations for cancer prevention, thereby contributing to the development of potential strategies for clinical trials in which diet-related interventions would be used in combination with immunotherapy to alter the levels of SFAs in patients and thereby improve the outcomes in cancer patients. Nonetheless, further high-quality studies are warranted to confirm these associations.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Association of saturated fatty acids with cancer risk: a systematic review and meta-analysis

Mei,

Qian,

Hou

et al. 2024

Lipids Health Dis

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“…The frequent intake of saturated fats from dairy products has been positively associated with higher oral cancer risk, especially in people that consume significant amounts of cakes, cheese, or ice creambars. 28 Although some studies have related dairy products to head and neck neoplasms, the real influence of these foods on the genetic transcription factors expression in oral cancers has not been established so far. 29 Using dairy products to improve oral health may have several additional health effects.…”

Section: Discussionmentioning

confidence: 99%

Influence of dairy products consumption on oral cancer risk: A meta-analysis

Rodríguez-Archilla

Gomez-Fernandez

2023

J Dent Res Dent Clin Dent Prospects

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Background. The role of dairy product consumption on oral cancer risk is not yet fully clarified. Some studies have observed an inverse association between dairy consumption and oral cancer risk. This study aimed to determine the influence of dairy product consumption (milk, cheese, yogurt, butter) on oral cancer risk. Methods. A search for studies on dairy products and oral cancer was conducted in the following databases: PubMed (MEDLINE, Cochrane Library), Web of Science (WoS), and Scopus. The estimation of the odds ratio (OR) effect was performed with the generic inverse variance method using the logarithm of the effect with the standard error (SE) and 95% confidence intervals. Results. Twenty-one studies with 59271 participants (8,300 oral cancer patients and 50971 controls) were included in this meta-analysis. All dairy products significantly reduced oral cancer risk except butter (P=0.16). Milk intake reduced oral cancer risk by 27% (OR: 0.73; P<0.001); yogurt consumption by 25% (OR: 0.75; P<0.001), and cheese consumption by 21% (OR:0.79; P<0.01). Conclusion. Regular consumption of dairy products reduces oral cancer risk between 21% and 27%.

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“…The frequency with which food is consumed, along with the types of foods chosen and the consistency of the diet, collectively contribute to either the maintenance or degradation of oral health. For instance, diets high in sugars and carbohydrates have been consistently linked to an increased risk of dental caries [ 6 - 9 ], periodontal diseases [ 10 - 13 ], and oral cancers [ 14 , 15 ]. Conversely, the state of oral health can significantly impact an individual's ability to maintain a nutritious diet [ 16 ], affecting aspects such as mastication, taste perception, and nutritional intake.…”

Section: Introductionmentioning

confidence: 99%

A Bibliometric Analysis of Literature on the Impact of Diet on Oral Health

Dagli,

Haque,

Kumar

2024

Cureus

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The complex connection between oral health and dietary habits is fundamental to holistic well-being. Oral health is closely linked to dietary choices, both as a reflection and a factor in overall health. This bibliometric analysis investigates clinical trials published in the PubMed database spanning six decades to understand the landscape of research on the impact of diet on oral health. The analysis reveals a fluctuating yet generally increasing trend over the decades, with significant growth periods interspersed with occasional declines, culminating in a recent slight decrease in research output. With strong collaborative networks, Devizio and Proskin emerge as primary contributors. The University of Sydney has published the maximum number of clinical trials. Thematic clusters highlight diverse research facets, including physiological measurements, socio-economic influences, and biochemical aspects. The evolution in research priorities from experimental studies to longitudinal evaluations underscores the interdisciplinary nature of the field. The analysis of country-wise research output revealed that the United States, Germany, and Australia lead in scientific research output, with notable contributions to the global landscape. While larger countries like China and India are represented, their frequencies are relatively lower, suggesting potential areas for further exploration. Collaboration patterns vary between countries, influencing the global impact of their scientific output. Despite the limitations inherent in database selection, this study integrates bibliometric and thematic analyses to offer comprehensive insights into research trends and priorities.

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Association Between Dietary Fatty Acid Pattern and Risk of Oral Cancer

Cited by 7 publications

References 49 publications

Association of saturated fatty acids with cancer risk: a systematic review and meta-analysis

Association of saturated fatty acids with cancer risk: a systematic review and meta-analysis

Influence of dairy products consumption on oral cancer risk: A meta-analysis

A Bibliometric Analysis of Literature on the Impact of Diet on Oral Health

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