Association between dietary flavonoid intake and hypertension among U.S. adults

Wan, Yingying; Ma, Dan; Shang, Qinghua; Xu, Hao

doi:10.3389/fimmu.2024.1380493

Cited by 4 publications

(1 citation statement)

References 72 publications

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“…Consistently, a recent study, also from the NHANES, observed similar results. The intake of anthocyanidins but not total flavonoids was significantly linked to a lower risk of HTN (HR 0.81, 95%CI 0.66-0.99) [31]. Overall, anthocyanidin intake is beneficial in reducing the risk of HTN.…”

Section: Comparison With Previous Studiesmentioning

confidence: 94%

Associations of Flavonoid Intakes with Mortality among Populations with Hypertension: A Prospective Cohort Study

Wang,

Lu,

Yang

et al. 2024

Nutrients

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Background: The effect of flavonoid consumption on all-cause and special-cause mortality remains unclear among populations with hypertension. Methods: A total of 6110 people with hypertension from three NHANES survey cycles (2007–2008, 2009–2010, and 2017–2018) were enrolled in this study. Cox proportional hazard models were conducted to estimate the association between the intake of total flavonoids and flavonoid subclasses and all-cause, cancer-related, and cardiovascular disease (CVD)-related mortality. Nonlinear relationships were identified using restricted cubic splines (RCS). Results: During 43,977 person-years of follow-up, 1155 participants died from any cause, 282 participants died from CVD, and 265 participants died from cancer. After adjusting for relevant confounders, including demographic, lifestyle, and dietary intake, a higher intake of total flavonoids was significantly associated with lower all-cause mortality but not CVD-related and cancer-related mortality among the population with hypertension. Compared with extreme quartiles, the hazard ratio (HR) and 95% confidence interval (CI) were 0.74 (0.56–0.97) for all-cause mortality, 0.77 (0.40–1.46) for CVD-related mortality, and 0.62 (0.35–1.08) for cancer-related mortality. In terms of all-cause mortality, this inverse association was optimized at total flavonoid consumption of approximately 375 mg/day. In addition, the negative association between total flavonoid consumption and all-cause mortality was more pronounced in non-obese (BMI < 30 kg/m2) compared to obese (BMI ≥ 30 kg/m2) populations. Higher intakes of anthocyanidin, flavan-3-ol, flavonol, and isoflavone were significantly associated with lower all-cause mortality (HR (95%CI): 0.70 (0.55–0.89); 0.76 (0.59–0.96); 0.66 (0.46–0.94); 0.79 (0.67–0.93), respectively). Higher intakes of anthocyanidin, flavan-3-ol, and flavonol were significantly associated with lower cancer-related mortality (HR (95%CI): 0.55 (0.32–0.93); 0.51 (0.31–0.82); 0.52 (0.28–0.96), respectively). Conclusion: This study suggests that a heightened consumption of total flavonoids and some flavonoid subclasses was linked to lower mortality, which supports the proposal of increasing flavonoid intake as part of healthy diets in patients with hypertension.

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Section: Comparison With Previous Studiesmentioning

confidence: 94%

Associations of Flavonoid Intakes with Mortality among Populations with Hypertension: A Prospective Cohort Study

Wang,

Lu,

Yang

et al. 2024

Nutrients

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Can nutritional scores improve the WHO calibrated non-laboratory risk prediction model for cardiovascular disease? Golestan Cohort Study

jabbari,

Eini-Zinab,

Kalhori

et al. 2024

J Diabetes Metab Disord

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Long-Term Impact of Nutritional Intervention with Increased Polyphenol Intake and Physical Activity Promotion on Oxidative and Inflammatory Profiles in Patients with Metabolic Syndrome

Quetglas-Llabrés,

Monserrat-Mesquida,

Bouzas

et al. 2024

Nutrients

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Obesity and overweight pose significant risks to health, contributing to the prevalence of chronic conditions like type 2 diabetes mellitus (T2DM) and cardiovascular diseases (CVD). The current study aimed to assess the impact of a 6-year nutritional and lifestyle intervention on oxidative and inflammatory markers in individuals aged 55 to 75, specifically those at high risk of CVD. A study was carried out in a group of 80 participants with metabolic syndrome (MetS) residing in Mallorca, Spain, who underwent nutritional intervention based on a low-calorie Mediterranean diet (MedDiet) and promotion of physical activity. Before and after the intervention, several parameters including anthropometric data, haematological factors, blood pressure, and physical activity level were measured. Oxidative and inflammatory biomarkers in plasma were analysed. After the 6-year intervention, participants who managed to reduce their body mass index (BMI) had greater reductions in abdominal obesity, waist to heigh ratio (WHtR), diastolic blood pressure, and glucose levels, and increased high density protein cholesterol (HDL-c) compared to those who did not reduce BMI. This higher reduction in BMI was related to reduced energy intake and increased adherence to MedDiet, with greater polyphenol intake, and total physical activity (PA). Furthermore, improvements in oxidative stress and proinflammatory status were observed in participants who reduced their BMI. Significant reductions in the activity of the prooxidant enzyme, myeloperoxidase (MPO), levels of the lipid oxidation marker, malondialdehyde (MDA), and the proinflammatory chemokine, monocyte chemoattractant protein-1 (MCP-1,) were found in those who reduced their BMI. In contrast, participants who did not improve their BMI exhibited higher levels of proinflammatory markers such as MCP-1 and tumour necrosis factor α (TNFα), as well as increased activity of the antioxidant enzyme catalase (CAT). Current findings suggest that an effective way to reduce BMI is a hypocaloric MedDiet combined with tailored physical activity to improve oxidative stress and proinflammatory status, and potentially reducing the risk of CVD.

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Association between dietary flavonoid intake and hypertension among U.S. adults

Cited by 4 publications

References 72 publications

Associations of Flavonoid Intakes with Mortality among Populations with Hypertension: A Prospective Cohort Study

Associations of Flavonoid Intakes with Mortality among Populations with Hypertension: A Prospective Cohort Study

Can nutritional scores improve the WHO calibrated non-laboratory risk prediction model for cardiovascular disease? Golestan Cohort Study

Long-Term Impact of Nutritional Intervention with Increased Polyphenol Intake and Physical Activity Promotion on Oxidative and Inflammatory Profiles in Patients with Metabolic Syndrome

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