Association between dietary total antioxidant capacity and breast cancer: a case–control study in a Middle Eastern country

Sasanfar, Bahareh; Toorang, Fatemeh; Maleki, Farzad; Esmaillzadeh, Ahmad; Zendehdel, Kazem

doi:10.1017/s1368980019004397

Cited by 23 publications

(11 citation statements)

References 31 publications

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“…The association of these nutrients with BC risk has been suggested in several studies [40][41][42][43]. Furthermore, this dietary pattern is high in dietary antioxidants such as proanthocyanidines, avonoids, stilbenes and alpha-tocopherols [44,39] which could reduce cancer risk [45][46][47]. Moreover, it is associated with lower circulating C-reactive protein which could explain the anti-in ammatory effect of this diet [48,49].…”

Section: Discussionmentioning

confidence: 97%

“…Decreased in ammation and enhanced antioxidant capacity of the body could suppress cell proliferation, spontaneous mutation and DNA methylation, all of which may lead to reduced cancer incidence. [47,50] The DASH dietary pattern insists on higher intake of ber and lower intake of simple carbohydrates, both of which are associated with lower glycemic index. It could therefore decrease the circulating level of insulin and insulin-like growth factor 1, which are associated with an elevated risk of ontogenesis [51,52].…”

Section: Discussionmentioning

confidence: 99%

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Adherence to the DASH Diet and Risk of Breast Cancer

Toorang

Sasanfar

Esmaillzadeh

et al. 2022

Clinical Breast Cancer

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Background: The Dietary Approach to Stop Hypertension (DASH) eating pattern has been recommended as a healthy dietary plan by several international guidelines. However, data on the association between the DASH diet and breast cancer (BC) is limited. This study investigated the association between the DASH dietary pattern and risk of BC.Methods: This is a hospital-based case-control study conducted between 2014 and 2016 in the Cancer Institute of Iran. Patients with histopathologically con rmed BC were recruited. Controls were healthy subjects who were frequency matched to cases by residential place and age (±10years). A validated 168-item Food Frequency Questionnaire (FFQ) was applied to assess the dietary intake of participants. Physical activity was assessed using the Global Physical Activity Questionnaire (GPAQ). The DASH dietary pattern scores were calculated using the method introduced by Fung. Unconditional logistic regression, in which potential confounders were taken into account, was applied to determine the association between adherence to the DASH dietary pattern and odds of BC.Results: The study participants comprised 477 patients with BC and 507 healthy controls. In the total population, patients with BC were slightly older (45.9 vs. 43.9 y, P=0.02), had slightly higher BMI (21.9 vs. 20.2, P=0.01) and were less physically active (20 vs. 27 MET h/wk. P<0.01) than controls. In Model A, which was adjusted for age and energy intake, adherence to the DASH dietary pattern substantially reduced BC risk in the total population (OR for comparing extreme tertiles: 0.62; 95% CI 0.44-0.78; P trend =0.004). Even after controlling for more cofounders, greatest adherence to DASH diet was associated with a 34% reduction in risk of BC (OR 0.66; 95% CI 0.46, 0.94; P trend =0.03). In premenopausal women, adherence to the DASH dietary pattern was insigni cantly associated with a 32% reduction in BC risk. This risk reduction was 38% in postmenopausal women, which was also not found to be signi cant Conclusion: Adherence to the DASH dietary pattern could be associated with an approximately 30% reduction in risk of BC. However, further studies, in particular studies with prospective design, are required to con rm this claim.

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Section: Discussionmentioning

confidence: 97%

Section: Discussionmentioning

confidence: 99%

Adherence to the DASH Diet and Risk of Breast Cancer

Toorang

Sasanfar

Esmaillzadeh

et al. 2022

Clinical Breast Cancer

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“…In addition, we did not examine the validity of this questionnaire for assessment of dietary TAC. However, earlier publications based on this questionnaire have revealed that data on dietary TAC from this questionnaire can be used to predict the chronic conditions ( 36 ). Moreover, some components of DDS and AHEI including corn flakes and alcohol consumption were not considered in this study, because of the lack of data in the original data set.…”

Section: Discussionmentioning

confidence: 99%

Association Between Dietary Total Antioxidant Capacity and Diet Quality in Adults

et al. 2022

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BackgroundDiet quality is a major contributor to human health. In addition, antioxidants have a great contribution to several chronic conditions. The purpose of this study was to evaluate if dietary total antioxidant capacity (TAC) can be considered as a measure of diet quality in a Middle Eastern country.MethodsIn this cross-sectional study on 6,724 Iranian adults, we used a validated food frequency questionnaire (FFQ) to assess dietary intakes. Data derived from the FFQ was used to calculate dietary TAC and well-known diet quality scores including alternate healthy eating index (AHEI) and dietary diversity score (DDS). Dietary TAC was calculated based on the ferric reducing-antioxidant power (FRAP) values reported in earlier publications. AHEI and DDS have also been constructed based on previous publications. Cross-classification was used to examine the agreement between these measures.ResultsMean age and BMI of study participants were 36.89 ± 8.08 y and 24.97 ± 3.87 kg/m2, respectively. We found that individuals in the highest tertile of dietary TAC had higher scores of AHEI (57.53 ± 0.20 vs. 52.03 ± 0.20, P < 0.001) and DDS (5.56 ± 0.03 vs. 4.15 ± 0.03, P < 0.001) compared with those in the lowest tertile. Participants' distribution on the basis of the cross-classification analysis indicated that the classifications were in exact agreement for 42.6%, within an adjacent tertile for 33.05%, and in gross misclassification for 20% of individuals. When this was examined between dietary TAC and DDS, we found that exact agreement in the classifications was for 59.2% of participants. Notably, a very low proportion of gross misclassification was seen in this regard such that only 6% of participants were classified in the opposing tertiles, indicating additional support for a good agreement.ConclusionWe found that dietary TAC might be considered as a proper measure for the assessment of diet quality because it was well correlated with well-known measures of diet quality including DDS and AHEI scores.

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“…Among cancers, breast cancer is suggested as a serious female malignant tumor with a high incidence in the world (Siegel et al., 2016). Epidemiological studies have shown that increased intake of fruits, vegetables, and whole grains have provided a significant inverse association with breast cancer (Karimi et al., 2014; Marzbani et al., 2019; Rigi et al., 2021; Sasanfar et al., 2021). Frequent consumption of functional foods, fresh fruits, and vegetables is an effective way to reduce the incidence of various cancers and improve the quality of life of patients (Joshipura & Kaumudi, 2001).…”

Section: Resultsmentioning

confidence: 99%

Differential effects of phenolic extracts from red‐fleshed apple peels and flesh induced G1 cell cycle arrest and apoptosis in human breast cancer MDA‐MB‐231 cells

Lin

Zhao

et al. 2021

Journal of Food Science

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Red-fleshedapples are preferredbecause of their high content of phenolics and antioxidants in peel and pulp. Herein, we evaluated the mechanisms of apple peel polyphenolic extracts (APP) and apple flesh polyphenolic extracts (AFP) from the new red-fleshed apple in inhibiting cell proliferation and inducing apoptosis on human breast cancer MDA-MB-231 cells. The antiproliferative activities were determined by the CCK8 assay. The expression of proteins was determined using Western blot. We found that the content of polyphenols and flavonoids in APP was significantly higher than that in AFP, and 14 main phenolic compounds in APP and AFP were quantified using UPLC-MS/MS techniques. Besides, the significant inhibition effects of APP and AFP were achieved through Akt pathway by inducing apoptosis (significantly upregulating reactive oxygen species [ROS] levels, and downregulating expression of pAkt, pBad, Bcl-2, promoting Cytochrome c release, activating Cle-Caspase 9, and inducing expressions of Cle-Caspase 3 and Cle-PARP), and inducing G0/G1 cell cycle arrest (increased expressions of p-p53 and p21 and decreased expressions of PCNA and Cyclin D1). And the inhibition effect of APP was stronger than that of AFP. These results suggest that AFP and APP may be excellent sources of natural chemicals for treating triple-negative breast cancer MDA-MB-231 cells. Practical Application:The effects of antiproliferation of phenolic extracts from red-fleshed apple peels and flesh on human breast cancer MDA-MB-231 cells were evaluated. The data may clarify the functional parts of red-fleshed apple and provide some basis for scientific researchers and consumers to recognize and exploit red-fleshed apple.

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Association between dietary total antioxidant capacity and breast cancer: a case–control study in a Middle Eastern country

Cited by 23 publications

References 31 publications

Adherence to the DASH Diet and Risk of Breast Cancer

Adherence to the DASH Diet and Risk of Breast Cancer

Association Between Dietary Total Antioxidant Capacity and Diet Quality in Adults

Differential effects of phenolic extracts from red‐fleshed apple peels and flesh induced G1 cell cycle arrest and apoptosis in human breast cancer MDA‐MB‐231 cells

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