Association Between Disease Severity and Calcium Concentration in Critically Ill Patients Admitted to Intensive Care Unit

Sanaie, Sarvin; Mahmoodpoor, Ata; Hamishehkar, Hadi; Shadvar, Kamran; Salimi, Nasim; Montazer, Majid; Iranpour, Afshin; Faramarzi, Elnaz

doi:10.5812/aapm.57583

Cited by 13 publications

(15 citation statements)

References 20 publications

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“…Studies have shown that both total calcium and adjusted calcium ion concentrations in ICU experimental group patients can assess disease severity to a certain extent [21].…”

Section: Discussionmentioning

confidence: 99%

Relationship of Hypocalciamia and Severity of Disease in COVID-19 Patients in Lahore Pakistan

Hamid¹,

Shah²,

Rasool³

et al. 2021

AJBLS

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Introduction: In Pakistan, a wave of coronavirus has started in February which was first reported in Wahun City China. Abnormal calcium blood level is considered one of the important and common electrolyte disturbances in patients with severe infection. The effect of blood calcium level on the severity of COVID-19 and the possible immune regulation mechanism is considered to be an important factor related to severity of disease. Aim of the Study: To find out the correlation of blood calcium levels and related risk factors of patients suffering from COVID-19 and provide a basis for early intervention in patients with relevant clinical characteristics and further reduce the incidence of critical illness and mortality in COVID-19 patients. Method: 180 COVID-19 patients were admitted to Gulab Devi Teaching Hospital, Lahore between February to July 2020. Subject index were tested on real-time fluorescent RT-PCR test. On the basis of the result of RT-PCR, they were divided into two groups according to clinical symptoms as mild (control/placebo group) and critical (experimental group). The patient with the mild symptom were included in the placebo group, whereas patient with the severe symptoms were included in the experimental group. Exclusion criteria: The patients who do not show the detection level of viral infection with the RT-PCR are excluded from the study. Results: The comparison has been carried out between the placebo group and the experimental group on the basis of various parameters. The patients serum calcium level was tested and the value for hypocalcemia was declared as per universal recommendation which is < 2.13mmol/L. According to the corrected serum total calcium level, COVID-19 patients can be divided into hypocalcemia group and normal blood calcium group. The result showed that hypocalcemia and immune dysfunction was found high in experimental group as compare to control group which shows a strong correlation between hypocalcemia and COVID-19 disease. Conclusion: It has been concluded from the study that patients with COVID-19 have obvious hypocalcemia and immune dysfunction, especially in experimental group patients. In this study, it is easy to be combined with multiple infections caused by pathogenic bacteria under certain conditions. Close monitoring of blood calcium levels can predict the severity of the disease more effectively.

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“…Studies have shown that both total calcium and adjusted calcium ion concentrations in ICU experimental group patients can assess disease severity to a certain extent [21].…”

Section: Discussionmentioning

confidence: 99%

Relationship of Hypocalciamia and Severity of Disease in COVID-19 Patients in Lahore Pakistan

Hamid¹,

Shah²,

Rasool³

et al. 2021

AJBLS

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“…It is also likely that hypocalcemia in hospitalized patients with COVID-19 and its association with more severe COVID-19 may be a marker of severe illness. Indeed, it was shown that hypocalcemia was common in patients with critical disease admitted to the ICU and was associated with poor prognosis [13].…”

Section: Mechanisms Of Hypocalcemia In Covid-19mentioning

confidence: 99%

Prognostic value of hypocalcemia in COVID-19

Mikhail¹,

Wali²

2020

Integr Food Nutr Metab

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Background: Preliminary data suggest that hypocalcemia is common among patients with coronavirus 2019 admitted to the hospital.Objective: To examine the prognostic value of hypocalcemia in the setting of COVID-19.Methods: Literature search (Pubmed) until September 15, 2020. Search terms include hypocalcemia, COVID-19, mortality, complications. Retrospective studies are reviewed due to lack of randomized trials.Results: Hypocalcemia is the most common electrolyte abnormality in patients with COVID-19 admitted to the hospital after hyponatremia. Prevalence of hypocalcemia among hospitalized patients with COVID-19 ranges from 9.5% to 78% depending on the definition of hypocalcemia and patients' characteristics. In most cases, hypocalcemia is mild to moderate biochemically. Hypocalcemia is a risk factor for hospitalization of patients with COVID-19. In already hospitalized patients, hypocalcemia is significantly associated with increase severity of COVID-19 and its complications including multi-organ failure, intensive care unit (ICU) admission, need for mechanical ventilation, acute respiratory distress syndrome (ARDS), and death. Hypocalcemia is significantly correlated with inflammatory markers of COVID-19. Causes of hypocalcemia in COVID-19 patients are unclear, but vitamin D deficiency may be a contributing factor. Conclusions: Hypocalcemia is common in hospitalized patients with COVID-19 and carries unfavorable outcomes. Further studies are needed to examine causes of hypocalcemia in COVID-19 and to see whether normalization of circulating calcium levels improve prognosis.

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“…Traumatic brain injury (TBI) is one of the common causes of long-term disabilities and mortality. Each year, about 50,000 people in the United States alone and 10 million worldwide die due to TBI (1)(2)(3)(4)(5). Treatment-related costs in patients with TBI imposes a heavy economic burden on the individual and the society due to poor recovery process, long-term disability, and its higher incidence in young people.…”

Section: Introductionmentioning

confidence: 99%

Evaluation of the Effect of Atorvastatin Administration on the Outcomes of Patients with Traumatic Brain Injury: A Double-blinded Randomized Clinical Trial

Soltani¹,

Janatmakan²,

Jorairahmadi³

et al. 2021

Anesth Pain Med

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Background: Traumatic brain injury (TBI) is one of the common causes of long-term disabilities and mortality. This study aimed to evaluate the effect of atorvastatin administration on the Glasgow Coma Scale (GCS), Glasgow Outcome Scale (GOS), and Disability Rating Scale (DRS) in patients with TBI. Methods: This double-blinded randomized clinical trial included 60 patients with TBI in Golestan Hospital of Ahvaz, Iran. After obtaining an informed consent from all patients, the patients were randomly assigned into two groups. For the intervention group, atorvastatin with a daily dose of 20 mg was used. The control group was administered the same amount of placebo for 10 days. Changes in the level of consciousness were measured using the GCS, and functional recovery rate in patients was measured by GOS and DRS in the third follow-up month. Results: According to the obtained results, compared with the control group, the atorvastatin administration significantly increased the level of GCS and DRS within 2 - 3 months post-intervention and improved GOS since the tenth day after the study (P < 0.05). Conclusions: The results revealed the positive effect of atorvastatin on the improvement of outcomes measurements such as GCS, DRS, and GOS in patients after moderate and severe TBI.

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Association Between Disease Severity and Calcium Concentration in Critically Ill Patients Admitted to Intensive Care Unit

Cited by 13 publications

References 20 publications

Relationship of Hypocalciamia and Severity of Disease in COVID-19 Patients in Lahore Pakistan

Relationship of Hypocalciamia and Severity of Disease in COVID-19 Patients in Lahore Pakistan

Prognostic value of hypocalcemia in COVID-19

Evaluation of the Effect of Atorvastatin Administration on the Outcomes of Patients with Traumatic Brain Injury: A Double-blinded Randomized Clinical Trial

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