Association between dopamine D4 receptor (DRD4) exon III polymorphism and Neuroticism in the Japanese population

Tochigi, Mamoru; Hibino, Hiroki; Otowa, Takeshi; Kato, C.; Marui, Tetsuya; Ohtani, Toshiyuki; Umekage, Tadashi; Kato, Nobuo; Sasaki, Tsukasa

doi:10.1016/j.neulet.2006.01.020

Cited by 86 publications

(30 citation statements)

References 15 publications

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“…For example, neuroticism is associated with the short allele of the DRD4 exon III polymorphism (Tochigi et al, 2006); the number of CAG repeats at the androgen receptor (AR) gene in men (Westberg et al, 2009); the serotonin transporter promoter 5-HTTLPR short allele (Sen, Burmeister, & Ghosh, 2004); and the GABA(A) Alpha 6 receptor Pro385Ser Pro allele (Sen et al, 2004). Extraversion is also associated with the number of CAG repeats at the AR locus (Lukaszewski & Roney, 2011;Westberg et al, 2009).…”

Section: The Heritability Of Personalitymentioning

confidence: 99%

Evolved individual differences: Advancing a condition-dependent model of personality

Lewis

2015

Personality and Individual Differences

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a b s t r a c tThe field of personality psychology offers a wealth of robust empirical research and a successful descriptive taxonomy, but neither explains the origins of the structure of human personality nor elaborates a generative framework for predicting the specific conditions that evoke the development of distinct personality traits. Exploration of traditional personality constructs within an evolutionary adaptive individual differences framework may help fill this explanatory gap. Personality traits exhibit functional features and patterns of variation expected from psychological adaptations designed to solve survival-and reproduction-related challenges recurrently faced during our species' evolutionary history. Conditiondependent evolutionary models of personality have been proposed for decades, but only recently have begun to see empirical investigation. These models posit that species-typical psychological mechanisms take as input cues from the individual's phenotype that would have been ancestrally linked to differential cost-benefit tradeoffs of alternative personality strategies, and produce as output personality trait levels with the greatest probabilistic net benefit for the individual. This paper elaborates a more nuanced conceptual framework that builds on earlier conceptualizations of condition-dependent traits to yield new and untested hypotheses about personality trait variation and covariation. It then describes clear future research directions for empirically investigating these readily testable hypotheses.

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Section: The Heritability Of Personalitymentioning

confidence: 99%

Evolved individual differences: Advancing a condition-dependent model of personality

Lewis

2015

Personality and Individual Differences

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“…5-HTTLPR and DRD4 are associated with the frequency of sexual activity among middle-aged men (Hamer, 2002) and age at first sexual intercourse (Guo & Tong, 2006). These two polymorphisms also are related to psychological traits and well-being (Lesch et al, 1996;Tochigi et al, 2006).…”

Section: Family Influences On the Association Between Age At First Bimentioning

confidence: 99%

Age at First Birth and Fathers' Subsequent Health: Evidence From Sibling and Twin Models

Pudrovska

Carr

2007

Am J Mens Health

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the confounding influences of unobserved early-life characteristics. However, the effect of age at first birth on fathers' health is explained by men's socioeconomic and family statuses. Whereas most research linking birth timing to specific diseases focuses narrowly on biological mechanisms among mothers, this study demonstrates the importance of reproductive decisions for men's health and well-being.

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“…In addition, the association between the dopamine receptor D4 (DRD4) variable number of tandem repeats (VNTR) exon III polymorphism and neuroticism has been reported [12] . Among the polymorphic variations in the VNTR from 2-repeat (2R) to 10R units, 7R is related to diminished cAMP reduction potency and subsequently influences decreased inhibitory postsynaptic dopamine effects compared with 4R [13] .…”

Section: Introductionmentioning

confidence: 99%

Association of DRD4 and COMT Polymorphisms with Disgust Sensitivity in Healthy Volunteers

Kang

Kim²,

Namkoong³

et al. 2010

Neuropsychobiology

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Background: Disgust is a basic emotion that involves feelings of revulsion and withdrawal behavior from dangerous/infectious situations. Very little is known about the genetic basis of disgust sensitivity. The dopamine receptor D4 (DRD4) and catechol-O-methyltransferase (COMT) genes have been implicated in neuroticism-related traits and approach-related temperaments which are supposed to be associated with disgust sensitivity. The present study aimed to investigate the possible relationship between disgust sensitivity and COMT Val158Met and DRD4 variable number of tandem repeats (VNTR) polymorphisms in healthy subjects. Methods: In total, 241 healthy Korean college students were recruited, and the 228 participants with a complete data set (127 males and 101 females) were included in the data analysis. Disgust sensitivity was assessed using the Disgust Scale-Revised (DS-R) and genotyping of COMT Val158Met and DRD4 VNTR polymorphisms was performed. Results:The Val/Val groups of COMT had significantly higher scores than the non-Val/Val group for the Animal-Reminder and the Contamination-Based Disgust scores as well as for total DS-R scores. Additionally, the non-2-repeat allele group of DRD4 had a tendency to a significantly higher disgust sensitivity than the 2-repeat allele group for Contamination-Based Disgust. Conclusions: These findings suggest that disgust sensitivity may be affected by genetic components, such as dopamine-related genes.

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Association between dopamine D4 receptor (DRD4) exon III polymorphism and Neuroticism in the Japanese population

Cited by 86 publications

References 15 publications

Evolved individual differences: Advancing a condition-dependent model of personality

Evolved individual differences: Advancing a condition-dependent model of personality

Age at First Birth and Fathers' Subsequent Health: Evidence From Sibling and Twin Models

Association of DRD4 and COMT Polymorphisms with Disgust Sensitivity in Healthy Volunteers

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