Association between duration of coal dust exposure and respiratory impairment in coal miners of West Bengal, India

Prasad, Shilpi Kumari; Singh, Siddhartha; Bose, Ananya; Prasad, Bimlesh; Banerjee, Oly; Bhattacharjee, Ankita; Maji, Bithin Kumar; Samanta, Amalendu; Mukherjee, Sandip

doi:10.1080/10803548.2020.1742463

Cited by 16 publications

(13 citation statements)

References 17 publications

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“…In recent years, death from respiratory diseases is still an important occupational hazard for coalminers. The relationships between occupational exposures to coalmine dust and mortality from coal workers' pneumoconiosis and chronic obstructive pulmonary disease have been clearly established [3][4][5]. The mortality risk of lung cancer for coalminers has also been assessed in a series of epidemiological studies [6][7][8].…”

Section: Introductionmentioning

confidence: 99%

Association between Coalmine Dust and Mortality Risk of Lung Cancer: A Meta-Analysis

Jiang

et al. 2021

BioMed Research International

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Background. Evidence on the carcinogenicity of coalmine dust in occupational settings is still conflicting. Therefore, we conducted this research to evaluate the mortality risk of lung cancer for coalminers exposed to occupational dust when compared to population with no or low dust exposure. Methods. Databases of PubMed and Chinese National Knowledge Infrastructure as well as reference lists were searched updated to September 18, 2020. The enrolled articles should report lung cancer mortality risk for coalminers exposed to occupational dust. Basic information was extracted such as the author and publication year, area and ethnicity, the type and estimates of outcome, duration of follow-up, and the study design. The checklists from Agency for Healthcare Research and Quality and the Newcastle-Ottawa Scale were used for the assessment of quality and bias risk for descriptive studies, cohort studies, and case control studies, respectively. The overall relative risks were calculated while Begg’s and Egger’s tests and sensitivity analysis were performed to explore potential heterogeneity sources. Metaregression and subgroup analyses were also conducted to give more detailed information for the correlation between dust exposure and lung cancer mortality. Results. A total of 19 articles with 22 different studies (descriptive study, case control study, and cohort study) including 8909 observed deaths from 1964 to 2017 were enrolled with a significant heterogeneity ( I 2 = 95 % , P < 0.001 ). The pooled relative risk of mortality from lung cancer was 1.16 (1.03-1.30) for coalminers. Results of metaregression analysis indicated that the high heterogeneity among these enrolled studies might be caused by the ethnicity differences ( P = 0.011 ). Subgroup analysis also indicated that the pooled estimate for Asian population in China was 4.94 (3.95-6.17) with I 2 = 39.3 % and P = 0.192 . All these results suggested that exposure to occupational dust would significantly increase the mortality risk of lung cancer, especially for Asian population in China, which should be measured and controlled more strictly. Discussion. This systematic review and meta-analysis provides high-quality evidence that exposure to occupational dust might increase the mortality risk of lung cancer, especially for Asian populations in China. The magnitude of this effect is of major public health importance in view of the ubiquitous existence of coalmining industry in China and even in the world. However, these pooled estimates should be interpreted cautiously because of the high heterogeneity among these publications. Other. This study was supported by the National Key Research and Development Program of China (Grant No. 2016YFC1302501).

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Section: Introductionmentioning

confidence: 99%

Association between Coalmine Dust and Mortality Risk of Lung Cancer: A Meta-Analysis

Jiang

et al. 2021

BioMed Research International

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“…Pengukuran tersebut menunjukkan hasil rata-rata nilai FVC pada kelompok terpajan yaitu 2.72±0.58 sedangkan pada kelompok tidak terpajan yaitu 2.97±0.73 dan hasil rata-rata nilai FEV1/FVC pada kelompok terpajan yaitu 78.13±9.66 sedangkan pada kelompok tidak terpajan yaitu 82.61±5.98 sehingga hasil keseluruhan indeks fungsi paru secara signifikan dari 230 responden yang terpajan debu batu bara dan 130 responden yang tidak terpajan adalah (p<0,050), gangguan fungsi paru yang tinggi ditemukan pada kelompok terpajan (43,91%) dibandingkan kelompok tidak terpajan (23,85%). 20 Shilpi dkk (2019) menyatakan hasil penelitiannya terhadap 230 responden yang terpajan debu dan 130 responden yang tidak terpajan menunjukkan nilai FVC, FEV1, dan rasio FEV1/FVC masing-masing adalah 2,72; 2,14; dan 78,13 dan nilainya menjadi lebih tinggi pada kelompok yang tidak terpapar yaitu 2.97; 2.46; dan 82.61. Distribusi fungsi paru menurut kebiasaan merokok pada kelompok bukan perokok yang tidak terpajan hasilnya mendekati nilai normal yaitu 90,41% sedangkan pada kelompok yang terpajan dan tidak terpajan yang memiliki kebiasaan merokok nilainya jauh lebih rendah yaitu 32,67%.…”

Section: Association Between Duration Of Coal Dustunclassified

“…Hal itu disebabkan karena pajanan debu berulang dengan waktu yang lama dapat menimbulkan inflamasi kronis dan berpengaruh terhadap penurunan fungsi paru yang signifikan. 20,27…”

Section: Masa Kerjaunclassified

Scoping Review: Efek Debu terhadap Fungsi Paru pada Penambang Batubara

Winarti¹,

Surialaga²,

Yuniarti³

2022

BCSMS

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Abstract. Dust is a solid particle measuring 1-100 μm in the air due to the process of crushing, breaking, and dismantling organic and inorganic materials such as coal. The coal mining process produces fine dust measuring 2.5 μm which can cause lung function disorders and cause respiratory diseases. The purpose of this scoping review is to determine the effect of dust on lung function in coal miners based on the research of the last ten years. This research method was carried out by scoping reviews of articles published by the database Pubmed, SpringerLink, Science direct, and Pro-Quest, published from 2011 to 2021. From 3,687 articles were filtered based on the inclusion criteria into 161 articles, then continued with filtration using the exclusion criteria were obtained 150 articles, and there were six articles duplications so that the articles that met the eligibility criteria based on PICOS were five articles. The analysis results of all articles showed that coal miners experienced a decrease in lung function characterized by decreased spirometry results. The conclusion of this study stated that dust affected lung function in coal miners characterized by impaired lung function either obstructive, restrictive, or mixed with the risk factors are age, smoking, years of service, personal dust exposure, and mine size. Abstrak. Debu merupakan partikel padat berukuran 1-100 μm yang berada di udara karena proses penghancuran, pemecahan dan pembongkaran bahan organik maupun nonorganik contohnya batubara. Proses penambangan batubara menghasilkan debu halus berukuran 2,5 μm yang dapat menyebabkan gangguan fungsi paru dan menimbulkan penyakit pernapasan. Scoping review ini bertujuan untuk mengetahui efek debu terhadap fungsi paru pada penambang batubara berdasarkan penelitian 10 tahun terakhir. Metode penelitian ini dilakukan dengan cara scoping review artikel yang dipublikasikan oleh database Pubmed, Springerlink, Science direct dan Pro-Quest, diterbitkan pada tahun 2011 sampai 2021. Dari 3.687 artikel dilakukan filtrasi berdasarkan kriteria inklusi terdapat 161 artikel, kemudian dilanjutkan dengan filtrasi menggunakan kriteria ekslusi didapat sebanyak 150 artikel dan terdapat duplikasi sebanyak 6 artikel sehingga artikel yang memenuhi kriteria kelayakan berdasarkan PICOS yaitu 5 artikel. Hasil analisis semua artikel menunjukan penambang batubara mengalami penurunan fungsi paru ditandai dengan hasil spirometri yang menurun. Kesimpulan penelitian ini menunjukan debu memiliki efek terhadap fungsi paru pada penambang batubara ditandai dengan adanya gangguan fungsi paru baik obstruktif, restriktif ataupun campuran dengan faktor resikonya adalah usia, merokok, masa kerja, paparan debu personal, dan ukuran tambang.

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“…Coal remains the primary source of electricity (60%) and iron production (40%) globally [ 1 ]. Coal dust hazards in coal mining have been studied continuously by the WHO (World Health Organization) and governments of many countries.…”

Section: Introductionmentioning

confidence: 99%

Coal dust exposure triggers heterogeneity of transcriptional profiles in mouse pneumoconiosis and Vitamin D remedies

Zou

et al. 2022

Part Fibre Toxicol

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Background Coal dust particles (CDP), an inevitable by-product of coal mining for the environment, mainly causes coal workers’ pneumoconiosis (CWP). Long-term exposure to coal dust leads to a complex alternation of biological processes during regeneration and repair in the healing lung. However, the cellular and complete molecular changes associated with pulmonary homeostasis caused by respiratory coal dust particles remain unclear. Methods This study mainly investigated the pulmonary toxicity of respirable-sized CDP in mice using unbiased single-cell RNA sequencing. CDP (< 5 μm) collected from the coal mine was analyzed by Scanning Electron Microscope (SEM) and Mass Spectrometer. In addition, western blotting, Elisa, QPCR was used to detect gene expression at mRNA or protein levels. Pathological analysis including HE staining, Masson staining, immunohistochemistry, and immunofluorescence staining were performed to characterize the structure and functional alternation in the pneumoconiosis mouse and verify the reliability of single-cell sequencing results. Results SEM image and Mass Spectrometer analysis showed that coal dust particles generated during coal mine production have been crushed and screened with a diameter of less than 5 µm and contained less than 10% silica. Alveolar structure and pulmonary microenvironment were destroyed, inflammatory and death (apoptosis, autophagy, and necrosis) pathways were activated, leading to pneumoconiosis in post 9 months coal dust stimulation. A distinct abnormally increased alveolar type 2 epithelial cell (AT2) were classified with a highly active state but reduced the antimicrobial-related protein expression of LYZ and Chia1 after CDP exposure. Beclin1, LC3B, LAMP2, TGF-ß, and MLPH were up-regulated induced by CDP, promoting autophagy and pulmonary fibrosis. A new subset of macrophages with M2-type polarization double expressed MLPH + /CD206 + was found in mice having pneumoconiosis but markedly decreased after the Vitamin D treatment. Activated MLPH + /CD206 + M2 macrophages secreted TGF-β1 and are sensitive to Vitamin D treatment. Conclusions This is the first study to reconstruct the pathologic progression and transcriptome pattern of coal pneumoconiosis in mice. Coal dust had obvious toxic effects on lung epithelial cells and macrophages and eventually induced pulmonary fibrosis. CDP-induced M2-type macrophages could be inhibited by VD, which may be related to the alleviation of the pulmonary fibrosis process.

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Association between duration of coal dust exposure and respiratory impairment in coal miners of West Bengal, India

Cited by 16 publications

References 17 publications

Association between Coalmine Dust and Mortality Risk of Lung Cancer: A Meta-Analysis

Association between Coalmine Dust and Mortality Risk of Lung Cancer: A Meta-Analysis

Scoping Review: Efek Debu terhadap Fungsi Paru pada Penambang Batubara

Coal dust exposure triggers heterogeneity of transcriptional profiles in mouse pneumoconiosis and Vitamin D remedies

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