Association between dyslipidaemia and the risk of hyperuricaemia: a six-year longitudinal cohort study of elderly individuals in China

Abstract

Background Despite abundant evidence linking dyslipidaemia to an increased risk of hyperuricaemia, the exact association between each component of dyslipidaemia and hyperuricaemia remains controversial. Thus, the objective of this research was to examine the correlation between dyslipidaemia and its components, as well as hyperuricaemia in Chinese people over the age of 60. Methods In this study, 4018 participants over 60 years without hyperuricaemia were investigated from 2014 to 2020. The association between each dyslipidaemia component and hyperuricaemia was evaluated employing Cox proportional hazards models. This research conducted further stratified and sensitivity analyses to assess the potential relationship. Results A total of 1155 participants suffered from hyperuricaemia (28.75%) at the time of the 6-year follow-up survey. In multivariable-adjusted analyses, compared to participants with normal lipid levels, those with dyslipidaemia had 1.28 times the risk (95% confidence interval 1.12 to 1.47) of experiencing hyperuricaemia. The hazard ratios (HR) (95% CI) comparing high TC, high TG, high LDL-C, and low HDL-C of dyslipidaemia with the regular group were 0.99 (0.72 to 1.37), 1.30 (1.07 to 1.57), 1.02 (0.70 to 1.50), and 1.20 (1.00 to 1.44), respectively. There was a nonlinear dose-response between TG, HDL-C, and serum uric acid (SUA). Conclusions Dyslipidaemia and its two distinct types, high TG and low HDL-C, increased hyperuricaemia incidence in this prospective cohort. Further research should be undertaken to investigate the possible reverse causality between different components of dyslipidaemia and hyperuricaemia.

Establishment and evaluation of a nomogram prediction model for the risk of vascular calcification in stage 5 chronic kidney disease patients

“…Elevated TG levels may result in an increase in free fatty acids and a faster breakdown of adenosine triphosphate, both of which lead to an increase in uric acid 40 . Xu et al found that high TG and low HDL-C were significantly and independently associated with the risk of HUA in a 6-year prospective study of Chinese older adults over 60 years old, and that there was a nonlinear increasing trend among TG, HDL-C, and SUA 41 . Hou et al found that the risk of HUA in patients with high TG was 2.353 times that in patients with normal TG.…”

Urate-Lowering Therapy Inhibits Thoracic Aortic Aneurysm and Dissection Formation in Mice

“…Serum uric acid has been reported to be elevated in patients with hypertension, diabetes, and dyslipidemia, and hyperuricemia is an independent predictor for various cardiovascular diseases. 5,50,51 The multiple logistic regression analysis with adjustment for blood pressure, total cholesterol, triglycerides, and glucose showed that serum uric acid levels were associated with TAA and TAD risks. The uratelowering drug allopurinol prevented TAAD development in the widely used BAPN-induced and Ang II-induced mouse models.…”

Establishment and evaluation of a nomogram prediction model for the risk of vascular calcification in stage 5 chronic kidney disease patients

“…Elevated TG levels may result in an increase in free fatty acids and a faster breakdown of adenosine triphosphate, both of which lead to an increase in uric acid 40 . Xu et al found that high TG and low HDL-C were signi cantly and independently associated with the risk of HUA in a 6-year prospective study of Chinese older adults over 60 years old, and that there was a nonlinear increasing trend among TG, HDL-C, and SUA 41 . Hou et al found that the risk of HUA in patients with high TG was 2.353 times that in patients with normal TG.…”