Association between early detection of soluble TNF-receptors and mortality in burn patients

Ribeiro, César Augusto João; Andrade, Carina Loureiro; Polanczyk, CA; Clausell, Nadine Oliveira

doi:10.1007/s00134-001-1190-5

Cited by 9 publications

(5 citation statements)

References 17 publications

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“…The presented research is consistent with the results from other centres [18,33,34]. The highest sTNFR1 levels were recorded at the time of admission to the ED in the whole group of patients.…”

Section: Discussionsupporting

confidence: 92%

“…Ribeiro et al [34] observed that the increase in sTNFR1 concentration negatively affected the prognosis of patients after burn injury. The authors of this study found that sTNFR1 concentrations were significantly elevated in both survivors and in the deceased, but statistically significant differences in sTNFR1 concentrations between groups were recorded.…”

Section: Discussionmentioning

confidence: 99%

“…It is known that elevated levels of TNF-α occur primarily after injuries (communication injuries, burns, surgery) and in sepsis. These injuries may have a similar cytokine release profile [34]. Elevated level of TNF-α may be an indicator of poor prognosis [33,34].…”

Section: Discussionmentioning

confidence: 99%

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Soluble tumour necrosis factor receptor I is a promising early indicator of complicated clinical outcome in patients following severe trauma

Binkowska

Michalak

Kopacz

et al. 2019

cejoi

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Post-traumatic mortality rates are still very high and show an increasing tendency. Early identification of patients at high risk of severe complications has a significant impact on treatment outcomes. The aim of the study was to better understand the early pathological inflammatory response to injury and infection, and to determine the usefulness of the assessment of TNF-α and sTNFR1 concentrations in the peripheral blood as early indicators of severe post-traumatic complications. The study was carried out in a group of 51 patients after trauma, treated in the ED, including 32 patients who met the inclusion criteria for immunological analysis. Patients were divided into two groups using the ISS scale (A ISS ≥ 20, B ISS < 20). The highest TNF-α and sTNFR1 concentrations in both groups were recorded at admission and were significantly higher in group A compared to group B (A vs. B TNF-α 2.46 pg/ml vs. 1.78 pg/ml; sTNFR1 1667.5 pg/ml vs. 875.2 p < 0.005). The concentration of sTNFR1 in patients with severe complications was significantly higher compared to patients without complications and preceded clinical symptoms of complications (C + vs. C -1561.5 pg/ml vs. 930.6 pg/ml, p < 0,005). The high diagnostic sensitivity calculated from the ROC curves was found for the concentrations of both cytokines: TNF-α (AUC = 0.91, p = 0.004) and sTNFR1 (AUC = 0.86, p = 0.011). Elevated levels of sTNFR1, determined in the peripheral blood shortly after injury, are significantly associated with the occurrence of later complications, which in some patients lead to death. In contrast, high levels of TNF-α shortly after injury are associated with mortality.

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Section: Discussionsupporting

confidence: 92%

Section: Discussionmentioning

confidence: 99%

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Soluble tumour necrosis factor receptor I is a promising early indicator of complicated clinical outcome in patients following severe trauma

Binkowska

Michalak

Kopacz

et al. 2019

cejoi

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“…Proinflammatory factors, such as tumor necrosis factor-α (TNF-α), C5a and leukotriene B4, chemoattractants (IL-8 and formyl-methionyl-leucyl-phenylalanine) and some growth factors (platelet-derived growth factor) were reported to be potent stimuli that upregulate the expression of CD11b [41][42][43]. Both clinical and experimental studies had demonstrated that numerous proinflammatory factors, such as TNF-α, IL-8 and C5a, could be induced by thermal injuries [25,[44][45][46]. So, the increased expression of CD11b on neutrophils and mono- Granulocytes were identified and gated by forward-and side-light scattering characteristics represented by MLFI using FACS assay.…”

Section: Discussionmentioning

confidence: 98%

Lactosyl derivatives function in a rat model of severe burn shock by acting as antagonists against CD11b of integrin on leukocytes

Zhao

Hu³

et al. 2008

Glycoconj J

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Severe burn shock remains an unsolved clinical problem with urgent needs to explore novel therapeutic approaches. In this study, the in vivo bioactivity of a series of synthetic lactosyl derivatives (oligosaccharides) was assessed on rats with burn shock to elucidate the underlying mechanisms. Administration of An-2 and Gu-4, two lactosyl derivatives with di- and tetravalent beta-D: -galactopyranosyl-(1-4)-beta-D: -glucopyranosyl ligands, significantly prolonged the survival time (P < 0.05 vs. saline), stabilized blood pressure and ameliorated the injuries to vital organs after burn. Flow chamber assay displayed that An-2 and Gu-4 markedly decreased the adhesion of leukocytes to microvessel endothelial cells. Competitive binding assay showed that a CD11b antibody significantly interrupted the interaction of An-2 and Gu-4 with leukocytes from rats with burn shock. With fluorescent microscopy, we further found that the oligosaccharides were selectively bound to leukocytes and with a colocalization of CD11b on the cell membrane. Interestingly, the lectin domain-deficient form of CD11b failed to bind with An-2 and Gu-4. The results suggest that both An-2 and Gu-4 significantly inhibit the adhesion of leukocytes to endothelial cells by binding to CD11b and thereby exert protective effects on severe burn shock.

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“…92 In severely burned patients, an early increase in sTNF-RI and sTNF-RII was reported to be associated with a higher risk for poor outcome. 93 Major surgery resulted in elevated sTNF-RI and sTNF-RII expression and high sTNF-RII levels were associated with increased post-operative rates of mortality. 94,95 It was concluded that high levels of antagonists to TNF-α represented persisted activation of SIRS in critically ill patients.…”

Section: Markers Of Mediator Activitymentioning

confidence: 99%

Inflammatory serum markers in patients with multiple trauma

Giannoudis

Hildebrand

Pape

2004

The Journal of Bone and Joint Surgery. British volume

141

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Association between early detection of soluble TNF-receptors and mortality in burn patients

Abstract: Early and progressive increase in sTNFR1 and sTNFR2 levels is associated with higher risk for poor outcome in severely burned patients.

Cited by 9 publications

References 17 publications

Soluble tumour necrosis factor receptor I is a promising early indicator of complicated clinical outcome in patients following severe trauma

Soluble tumour necrosis factor receptor I is a promising early indicator of complicated clinical outcome in patients following severe trauma

Lactosyl derivatives function in a rat model of severe burn shock by acting as antagonists against CD11b of integrin on leukocytes

Inflammatory serum markers in patients with multiple trauma

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