Association between early influenza vaccination and the reduction of influenza-like syndromes in health care providers

Saadeh-Navarro, Evelyn; Garza‐González, Elvira; Salazar-Montalvo, Raúl Gabino; Rodríguez-López, Juan; Mendoza-Flores, Lidia; Camacho-Ortíz, Adrián

doi:10.1016/j.ajic.2015.10.005

Cited by 5 publications

(7 citation statements)

References 6 publications

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“…Specific vaccination against influenza is strongly encouraged because it represents the very first action, effective for containing the spreading, the clinical impact, and the burden of the disease, in particular in elderly, in pediatric age, and in subjects at risk, or suffering from dangerous comorbidities [ 1 , 16 , 20 ]. Furthermore, early vaccination was recently proved to be effective also in reducing the frequency of I-LSs [ 21 ]. However, some specific anti-viral drugs are also available in the aim to prevent influenza and I-LS and/or to manage their symptoms, and some new molecules are still in development [ 10 , 15 , 22 – 25 ].…”

Section: Discussionmentioning

confidence: 99%

Influenza and influenza-like syndromes: the subjects’ beliefs, the attitude to prevention and treatment, and the impact in Italian general population

Negro¹,

Zanasi

Turco

et al. 2018

Multidiscip Respir Med

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BackgroundInfluenza and influenza-like syndromes (I-LSs) are infectious diseases occurring on a seasonal basis which can lead to upper (URTI) and lower respiratory tract illness (LRTI) of different severity. The approach to these disorders is unfortunately not uniform. Aim of the study was to investigate real-life people beliefs, the attitude to their prevention and treatment, and their impact in general population.MethodsA cross-sectional survey via Computer Assisted Telephone Interview (CATI) was carried out using a specific questionnaire investigating influenza episode rates, subjects behavior in case of influenza and I-LSs, and prescribed therapy.Results1,202 subjects completed the questionnaire: median age was 46, 49% male, 20% active smokers. 57% of respondents experienced at least one episode of influenza or I-LS in the previous 12 months; episodes were usually home-managed, shorter than 2 weeks and more frequent in fall and winter (73% of the total). GP resulted the first health-care option (56%); almost 3% of respondents referred to the emergency room, and hospitalization occurred in 1%. Mucolytics resulted the most prescribed drugs (55%) followed by antibiotics and aerosol therapy (37–38%). Even if more than 70% of subjects considered vaccination essential, only 14% received influenza vaccination yearly and almost 60% had never received vaccination. Approximately 36% of respondents regarded homeopathy (namely Oscillococcinum) as an helpful alternative because of perceived as safer.ConclusionsSeasonal prevalence of I-LSs and influenza partially overlap. As virus identification is not a common procedure in daily practice, only a clinical discrimination is possible. Antibiotic prescription is still too high and largely inappropriate. Influenza vaccination is strongly encouraged, but different strategies are also used. Other approaches are receiving increasing attention in general population, and subjects’ willingness to spend out-of-pocket for effective remedies is also increasing. The discrepancy between subjects’ beliefs and health care actions likely reflects the insufficiency of institutional preventive strategies. In general, the approach to influenza and I-LSs appear variable and highly dependent of subjects’ and their GPs’ cultural beliefs.

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Section: Discussionmentioning

confidence: 99%

Influenza and influenza-like syndromes: the subjects’ beliefs, the attitude to prevention and treatment, and the impact in Italian general population

Negro¹,

Zanasi

Turco

et al. 2018

Multidiscip Respir Med

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“…We identified 8 observational studies of moderate to lower moderate quality [19] , [20] , [21] , [22] , [23] , [26] , [27] , [30] , 5 of which found a vaccine benefit to HWs or employers and 3 which found no benefift or inconclusive results. A study in a large Italian hospital found an increase in absenteeism [19] from 2.99 days/person (outside of flu season) to 5.06 days/person (during flu season), which translated to 11,000 attributable absent days/year.…”

Section: Literature Search Resultsmentioning

confidence: 99%

“… 7 [11] , [12] , [13] , [14] , [15] , [16] , [17] What is the evidence that vaccinating staff in healthcare settings against influenza reduces influenza in HWs, absenteeism and/or the wider economic impact of influenza in the healthcare workforce? 14 [11] , [18] , [19] , [20] , [21] , [22] , [23] , [24] , [25] , [26] , [27] , [28] , [29] , [30] 2 The Impact of HW Influenza Vaccination on their patients What is the evidence that HWs transmit influenza (asymptomatic or symptomatic) to inpatients in healthcare settings? 11 [31] , [32] , [33] , [34] , [35] , [36] , [37] , [38] , [39] , [40] , [41] Does influenza vaccination of HWs provide a protective effect for inpatients in healthcare settings?…”

Section: Methodsmentioning

confidence: 99%

“… Yes/No Riphagen-Dalhuisen [28] 4 High Moderate cRCT The Netherlands 6 Tertiary Medical Centres All hospital HWs during 2009–2011 HWs = all from Multi-faceted uptake intervention for H1N1pdm09 and seasonal vaccine Vaccine uptake; absenteeism rates among HWs in December of each year No to absenteeism, actually saw an increase Hui [30] 4 High Moderate RCT Malaysia Faculty of Dentistry Staff/students of the faculty of Dentistry Control .Control = 176 Vaccinated = 179 Seasonal Vaccine Follow up over a 4-month period from vaccination, via questionnaire to ascertain self-reported outcomes: ILI prevalence; Recurrence of ILI; Visits to doctor due to ILI; Family members or housemates reporting ILI, Days of absenteeism due to ILI, Fever days due to ILI Yes, to all self-reported outcome measures Nguyen- VanTam [23] 2 Low moderate OS- RC-TS England Teaching Hospital, multiple wards HWs – non-medical staff (nurses/ porters); nursing staff from admissions, intensive therapy and surgical; porters dealing with supplies and waste N = 271 N/A Individual sickness absence contrasted epidemic/ non-epidemic periods in season. Measured: Total time lost/person as % of rostered time.# weeks/ person which absence occurred ‘92-‘93 season non-epidemic yr. comparison, since low flu activity No Atamna [26] 3 Moderate OS-PC Israel Medical Centre Health workers, vaccinated vs. non-vaccinated during flu seasons and not 733 vaccinated 908 not (199 in flu season) Seasonal Vaccine Rates of PCR confirmed influenza A infection in vaccinated vs. non vaccinated HWs inconclusive Njuguna [22] 2 Low moderate OS-PC Kenya 5 Hospitals with influenza surveillance Health Workers who were offered free vaccine 3803 H1N1pdm09 vaccine Vaccine effectiveness in vaccinated vs unvaccinated HCP: Incidence of acute respiratory illne...…”

Section: Methodsmentioning

confidence: 99%

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A rapid evidence appraisal of influenza vaccination in health workers: An important policy in an area of imperfect evidence

Jenkin

Mahgoub

Morales³

et al. 2019

Vaccine: X

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Introduction The World Health Organization recommends vaccination of health workers (HWs) against influenza, but low uptake is intransigent. We conducted a Rapid Evidence Appraisal on: the risk of influenza in HWs, transmission risk from HWs to patients, the benefit of HW vaccination, and strategies for improving uptake. We aimed to capture a ‘whole-of-system’ perspective to consider possible benefits for HWs, employers and patients. Methods We executed a comprehensive search of the available literature published from 2006 to 2018 in the English language. We developed search terms for seven separate questions following the PICO framework (population, intervention, comparators, outcomes) and queried nine databases. Results Of 3784 publications identified, 52 met inclusion criteria. Seven addressed HW influenza risk, of which four found increased risk; 15 addressed influenza vaccine benefit to HWs or their employers, of which 10 found benefit; 11 addressed influenza transmission from HWs to patients, of which 6 found evidence for transmission; 12 unique studies addressed whether vaccinating HWs produced patient benefit, of which 9 concluded benefits accrued. Regarding the number of HWs needed to vaccinate (NNV) to deliver patient benefit, NNV estimates ranged from 3 to 36,000 but were in significant disagreement. Fourteen studies provided insights on strategies to improve uptake; the strongest evidence was for mandatory vaccination. Conclusions The evidence on most questions related to influenza vaccination in HWs is mixed and often of low-quality. Substantial heterogeneity exists in terms of study designs and settings, making comparison between studies difficult. Notwithstanding these limitations, a majority of studies suggests that influenza vaccination benefit HWs and their employers; and HWs are implicated in transmission events. The effects of vaccinating HWs on patient morbidity and mortality may include reductions in all-cause mortality and influenza-like illness (ILI). Taken together, the evidence suggests that HW vaccination is an important policy for HWs themselves, their employers, and their patients.

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“…Although the Advisory Committee on Immunization Practices recommends that healthcare personnel receive an annual influenza vaccine, there is a wide variance in vaccination [3,4]. Higher rates of vaccination have been associated with a reduction in absenteeism and influenza-associated complications [5]. In Mexico, influenza vaccination for HCP is not obligatory, and compliance relies on promotion and persuasion.…”

Section: Introductionmentioning

confidence: 99%

Enhanced influenza vaccination among healthcare personnel prevents cases despite community burden

Medina-Piñón

Padilla-Orozco

Mendoza-Flores

et al. 2019

J Infect Dev Ctries

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Introduction: Influenza vaccination for healthcare personnel is not obligatory in Mexico, and compliance relies on promotion and persuasion. The objective of this study was to determine the impact of influenza vaccination compliance on the reduction of influenza and influenza-like illness among healthcare personnel throughout two consecutive influenza seasons. Methodology: A retrospective study comparing cases of influenza and influenza-like illness among vaccinated and unvaccinated healthcare personnel registered in a Mexican 500-bed University Hospital surveillance and immunization registry during seasons 2015-16 and 2016-17. Results: Total influenza immunization compliance was 21.3% and 42.7%, respectively. Reduction of the number of influenza-like illness (58 in 2015-16 and 15 in 2016-17; P = 0.0001) and confirmed influenza cases (28 in 2015-16 and 13 in 2016-17; P = 0.036) was evident. During 2016-17, influenza activity in the community was higher than 2015-16 (4800 and 1338 cases, respectively). Conclusions: Increased influenza vaccination compliance among healthcare personnel was associated with reduction of the overall number of influenza and influenza-like illness cases, even in the setting of high activity of the disease in the community through 2016-17 and reported suboptimal vaccine effectiveness during both seasons.

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Association between early influenza vaccination and the reduction of influenza-like syndromes in health care providers

Cited by 5 publications

References 6 publications

Influenza and influenza-like syndromes: the subjects’ beliefs, the attitude to prevention and treatment, and the impact in Italian general population

Influenza and influenza-like syndromes: the subjects’ beliefs, the attitude to prevention and treatment, and the impact in Italian general population

A rapid evidence appraisal of influenza vaccination in health workers: An important policy in an area of imperfect evidence

Enhanced influenza vaccination among healthcare personnel prevents cases despite community burden

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