Association between early life adversity and allostatic load in girls with precocious puberty

Li, Jing; Yu, Yue; Yuan, Jingyi; Liu, Deyun; Fang, Jugao; Wu, Peipei; Zhou, Yi; Wang, Ya; Sun, Ying

doi:10.1016/j.psyneuen.2023.106101

Cited by 5 publications

(4 citation statements)

References 90 publications

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“…[105][106][107] Our findings regarding the full mediation of AL on the path from polygenic risk of T2D to mental health burden, as opposed to the partial mediation of polygenic risk of MDD, may suggest that the effects of traitlike metabolic susceptibility on stress biology outweighs stress-related disease susceptibility effects. As allostatic load is implicated in accelerating developmental processes (e.g., precocious puberty 34 and accelerated cellular aging processes 108,109 ), our results present a key justification for the study and clinical utility of metabolic (and other physiological) system susceptibility in mental health and the necessity for an integration of systems approaches to understanding mental and physical health. 83,110,111 Together, our mediation analyses point toward allostatic load as a contributor on the causal pathway from converging risks of psychiatric and metabolic predispositions to mental health burden in early adolescence and may suggest AL as a potential target for interventions aimed at improving youth mental health outcomes.…”

Section: Discussionmentioning

confidence: 76%

“…[26][27][28][29] However, there is no consensus on measurement and operationalization of AL among youth. 8,[30][31][32][33][34][35] AL emerges as a cost of the chronic activation of stress-biology pathways in response to environmental adversity. 4,36,37 Upon exposure to stress, the human body responds with higher states of arousal in adaptation to the future demands of the environment, in a state termed allostasis, with the ultimate physiological goal to maintain reinstate stability through flexible regulation.…”

Section: Introductionmentioning

confidence: 99%

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Allostatic load in early adolescence: gene / environment contributions and relevance for mental health

Hoffman,

Tran,

Moore

et al. 2023

Preprint

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Background. Allostatic load is the cumulative 'wear and tear' on the body due to chronic adversity. We aimed to test poly-environmental (exposomic) and polygenic contributions to allostatic load and their combined contribution to early adolescent mental health. Methods. We analyzed data on N = 5,035 diverse youth (mean age 12) from the Adolescent Brain Cognitive Development Study (ABCD). Using dimensionality reduction method, we calculated and overall allostatic load score (AL) using body mass index [BMI], waist circumference, blood pressure, blood glycemia, blood cholesterol, and salivary DHEA. Childhood exposomic risk was quantified using multi-level environmental exposures before age 11. Genetic risk was quantified using polygenic risk scores (PRS) for metabolic system susceptibility (type 2 diabetes [T2D]) and stress-related psychiatric disease (major depressive disorder [MDD]). We used linear mixed effects models to test main, additive, and interactive effects of exposomic and polygenic risk (independent variables) on AL (dependent variable). Mediation models tested the mediating role of AL on the pathway from exposomic and polygenic risk to youth mental health. Models adjusted for demographics and genetic principal components. Results. We observed disparities in AL with non-Hispanic White youth having significantly lower AL compared to Hispanic and Non-Hispanic Black youth. In the diverse sample, childhood exposomic burden was associated with AL in adolescence (beta=0.25, 95%CI 0.22-0.29, P<.001). In European ancestry participants (n=2,928), polygenic risk of both T2D and depression was associated with AL (T2D-PRS beta=0.11, 95%CI 0.07-0.14, P<.001; MDD-PRS beta=0.05, 95%CI 0.02-0.09, P=.003). Both polygenic scores showed significant interaction with exposomic risk such that, with greater polygenic risk, the association between exposome and AL was stronger. AL partly mediated the pathway to youth mental health from exposomic risk and from MDD-PRS, and fully mediated the pathway from T2D-PRS. Conclusions. AL can be quantified in youth using anthropometric and biological measures and is mapped to exposomic and polygenic risk. Main and interactive environmental and genetic effects support a diathesis-stress model. Findings suggest that both environmental and genetic risk be considered when modeling stress-related health conditions.

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Section: Discussionmentioning

confidence: 76%

Section: Introductionmentioning

confidence: 99%

Allostatic load in early adolescence: gene / environment contributions and relevance for mental health

Hoffman,

Tran,

Moore

et al. 2023

Preprint

View full text Add to dashboard Cite

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“…The total allostatic load model suggests that chronic exposure to physical, mental, or environmental stressors leads to persistent release of primary mediators (e.g., inflammatory cytokines, cortisol) that disrupt physiological function and can lead to chronic disease [157,158]. Numerous systematic reviews have revealed that total allostatic load is associated with increased risk of chronic disease across the lifespan, including in childhood [159,160]. The parents were exposed to this concept by reading popular books on the topic of total allostatic load and autism [158], listening to autism-focused audio materials [156] provided by their coach and subsequently taking the Child Health Inventory for Resilience and Prevention (CHIRP) survey of the Documenting Hope Project, a comprehensive assessment of total allostatic load among children [161].…”

Section: Therapeutic Interventionsmentioning

confidence: 99%

Reversal of Autism among Dizygotic Twins through a Personalized Lifestyle and Environmental Modification Approach: A Case Report and Review of the Literature

D’Adamo,

Nelson,

Miller

et al. 2024

Preprint

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The prevalence of autism has been increasing at an alarming rate. Even accounting for the expansion of autism spectrum disorder diagnostic (ASD) criteria throughout the 1990’s, there has been an over 300% increase in ASD prevalence since the year 2000. The often debilitating personal, familial, and societal sequelae of autism are generally believed to be lifelong. However, there have been several encouraging case reports demonstrating reversal of autism diagnoses with a therapeutic focus on addressing the environmental and modifiable lifestyle factors believed to be largely underlying the condition. This case report describes the reversal of autism among dizygotic, female twin toddlers and provides a review of related literature describing associations between modifiable lifestyle factors, environmental exposures, and various clinical approaches to treating autism. The twins were diagnosed with Level 3 severity ASD “requiring very substantial support” at approximately 20 months of age following concerns of limited verbal and non-verbal communication, repetitive behaviors, rigidity around transitions, and extensive gastrointestinal symptoms, among other common symptoms. A parent-driven, multidisciplinary, therapeutic intervention involving a variety of licensed clinicians focusing primarily on addressing environmental and modifiable lifestyle factors was personalized to each of the twin’s symptoms, labs, and other outcome measures. Dramatic improvements were noted within several months in most domains of the twins’ symptoms, which was manifested in reductions of Autism Treatment Evaluation Checklist (ATEC) scores from 76 to 32 in one of the twins and from 43 to 4 in the other twin. The improvement in symptoms and ATEC scores has remained relatively stable for six months at last assessment. While prospective studies are required, this case offers further encouraging evidence of ASD reversal through a personalized, multidisciplinary approach focusing predominantly on addressing environmental and lifestyle risk factors.

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“…The total allostatic load model suggests that chronic exposure to physical, mental, or environmental stressors leads to the persistent release of primary mediators (e.g., inflammatory cytokines, cortisol) that disrupt physiological function and can lead to chronic disease [ 157 , 158 ]. Numerous systematic reviews have revealed that total allostatic load is associated with an increased risk of chronic disease across the lifespan, including in childhood [ 159 , 160 ]. The parents were exposed to this concept by reading popular books on the topic of total allostatic load and autism [ 158 ], listening to autism-focused audio materials [ 156 ] provided by their coach, and subsequently taking the Child Health Inventory for Resilience and Prevention (CHIRP) survey of the Documenting Hope Project, a comprehensive assessment of total allostatic load among children [ 161 ].…”

Section: Therapeutic Interventionsmentioning

confidence: 99%

Reversal of Autism Symptoms among Dizygotic Twins through a Personalized Lifestyle and Environmental Modification Approach: A Case Report and Review of the Literature

D’Adamo,

Nelson,

Miller

et al. 2024

JPM

View full text Add to dashboard Cite

The prevalence of autism has been increasing at an alarming rate. Even accounting for the expansion of autism spectrum disorder diagnostic (ASD) criteria throughout the 1990’s, there has been an over 300% increase in ASD prevalence since the year 2000. The often debilitating personal, familial, and societal sequelae of autism are generally believed to be lifelong. However, there have been several encouraging case reports demonstrating the reversal of autism diagnoses, with a therapeutic focus on addressing the environmental and modifiable lifestyle factors believed to be largely underlying the condition. This case report describes the reversal of autism symptoms among dizygotic, female twin toddlers and provides a review of related literature describing associations between modifiable lifestyle factors, environmental exposures, and various clinical approaches to treating autism. The twins were diagnosed with Level 3 severity ASD “requiring very substantial support” at approximately 20 months of age following concerns of limited verbal and non-verbal communication, repetitive behaviors, rigidity around transitions, and extensive gastrointestinal symptoms, among other common symptoms. A parent-driven, multidisciplinary, therapeutic intervention involving a variety of licensed clinicians focusing primarily on addressing environmental and modifiable lifestyle factors was personalized to each of the twin’s symptoms, labs, and other outcome measures. Dramatic improvements were noted within several months in most domains of the twins’ symptoms, which manifested in reductions of Autism Treatment Evaluation Checklist (ATEC) scores from 76 to 32 in one of the twins and from 43 to 4 in the other twin. The improvement in symptoms and ATEC scores has remained relatively stable for six months at last assessment. While prospective studies are required, this case offers further encouraging evidence of ASD reversal through a personalized, multidisciplinary approach focusing predominantly on addressing modifiable environmental and lifestyle risk factors.

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Association between early life adversity and allostatic load in girls with precocious puberty

Cited by 5 publications

References 90 publications

Allostatic load in early adolescence: gene / environment contributions and relevance for mental health

Allostatic load in early adolescence: gene / environment contributions and relevance for mental health

Reversal of Autism among Dizygotic Twins through a Personalized Lifestyle and Environmental Modification Approach: A Case Report and Review of the Literature

Reversal of Autism Symptoms among Dizygotic Twins through a Personalized Lifestyle and Environmental Modification Approach: A Case Report and Review of the Literature

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