Association Between Eight Adiponectin Polymorphisms, Obesity, and Metabolic Syndrome Parameters in Tunisian Volunteers

Boumaiza, Imen; Omezzine, Asma; Rejeb, Jaleleddine Ben; Raîs, L.; Rejeb, N.; Nabli, Naoufel; Abdelaziz, Ahmed Ben; Bouslama, Ali

doi:10.1089/met.2011.0035

Cited by 22 publications

(25 citation statements)

References 39 publications

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“…However, this study only assessed the genetic influence on IR using HOMA-IR under a codominant model and not the genetic influence on blood glucose. Furthermore, other studies [13,16,19,[22][23][24][25][26][27][28][29][30][31][32][33][34][35][36] regarding the association between the ADIPOQ T45G polymorphism and IR have been reported.…”

Section: Discussionmentioning

confidence: 99%

“…The remaining 19 studies consisted of both male and female subjects. In all 25 studies, 2 involved obese subjects [23,32], 3 involved T2D subjects [19,27,36], 7 involved non-diabetic and non-obese subjects [13,22,24,26,30,33,35], and 13 involved healthy subjects [14-18, 20, 21, 24, 25, 28, 29, 31, 34] (Table 1). Genotype distributions in all studies were in Hardy-Weinberg equilibrium, except in 1 study [36].…”

Section: Characteristics Of Studiesmentioning

confidence: 99%

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Association of the <i>ADIPOQ</i> T45G polymorphism with insulin resistance and blood glucose: A meta-analysis

et al. 2014

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InsulIn resIstance (Ir) is characterized by a decreased capacity of insulin to perform its normal physiological functions. IR is regulated by both environmental and genetic factors [1,2], and is considered as the core factor in the pathogenesis of metabolic syndrome and obesity. In recent years, numerous studies have revealed abundant information about the molecular mechanism of IR [3,4]. However, the exact pathogenesis underlying the development and progression of IR remains unclear.Adiponectin, the most abundant adipocyte-derived protein, is involved in the control of glucose, fat metabolism, and insulin sensitivity [5,6]. Adiponectindeficient mice exhibit IR and glucose intolerance [7,8], and animal models of obesity and IR show reduced plasma adiponectin levels [9,10]. Adiponectin exerts a potent insulin-sensitizing effect through its receptors AdipoR1 and AdipoR2, leading to the activation Association of the ADIPOQ T45G polymorphism with insulin resistance and blood glucose: A meta-analysis Results of published studies on the association of the ADIPOQ T45G polymorphism with insulin resistance (IR) and blood glucose are conflicting. In this study, we performed a meta-analysis to further investigate such an association. Articles that evaluate the effect of the T45G polymorphism on IR and blood glucose were identified from the PubMed and Embase databases. Five indices, including fasting blood glucose (FBG), fasting insulin (F-insulin), 2-h blood glucose (2-h BG), 2-h insulin, and homeostasis model assessment insulin resistance index (HOMA-IR), were used to assess the effects of the T45G polymorphism on IR and blood glucose under a dominant model. 24 articles involving 7630 subjects were included. Twenty-two studies on FBG, 17 on F-insulin, 20 on HOMA-IR, and 3 on 2-h BG were included. No study on 2-h insulin was found. This meta-analysis revealed no significant association between the ADIPOQ T45G polymorphism and IR and blood glucose in the overall population and subgroup subjects under a dominant model, regardless of whether FBG, F-insulin, 2-h BG, or HOMA-IR was used. The present meta-analysis indicated that the mutation allele may have no function in IR development. The ADIPOQ T45G polymorphism is not associated with IR and blood glucose.

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Section: Discussionmentioning

confidence: 99%

Section: Characteristics Of Studiesmentioning

confidence: 99%

Association of the <i>ADIPOQ</i> T45G polymorphism with insulin resistance and blood glucose: A meta-analysis

et al. 2014

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“…5) HDL cholesterol less than 40 in males and less than 50 in females (3). Concerning cardiovascular and metabolic factors, higher waist circumference is associated with increased risk of cardiovascular disease (4). Various modalities were tested to reduce waist circumference and metabolic syndrome caused by administration of olanzapine.…”

Section: Introductionmentioning

confidence: 99%

“…Cholecalciferol (vitamin D3) is the available form of this vitamin (6) and its oral form is consisted of 50 000 IU of vitamin D3 (7). Many obese people have low levels of this vitamin (4). The normal serum level of vitamin D is 30 to 80 ng/mL (8) such as depression and schizophrenia (9).…”

Section: Introductionmentioning

confidence: 99%

Therapeutic impact of cholecalciferol in patients with psychiatric disorders receiving olanzapine

Kaviyani¹,

Bahadoram²,

Houshmand³

et al. 2017

J Parathyr Dis

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Introduction: Psychiatric disorders such as schizophrenia require appropriate treatment. Second-generation antipsychotics, including olanzapine, are administered as an appropriated treatment for these disorders. However, this drug has several complications, such as obesity and increased waist circumference which reduces the acceptance of the treatment. Objectives: The aim of this study was to investigate the effects of vitamin D3 therapy on waist circumference caused by olanzapine. Patients and Methods: In this randomized clinical trial, 50 hospitalized women with psychiatric disorders receiving olanzapine were divided into two groups of intervention and control groups. Before the intervention, the waist circumference, hip circumference, and waist-hip ratio were measured. Then, for 12 weeks, the intervention group received vitamin D3 and the control group received paraffin as the placebo, one pearl every 2 weeks. Waist circumference, hip circumference, and waist-hip ratio were re-measured and the collected data were analyzed by pair t test. Results: Our findings showed that there is a significant decrease in waist circumference and waist-hip ratio in intervention group (P < 0.001). However, these changes were not significant in the placebo group. Hip circumference was not changed significantly in both groups. Conclusion: Vitamin D can be administered concomitant with 0lanzapine to improve side effects of olanzapine such as increasing waist circumference.

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“…It is involved in the homeostatic control of circulating glucose and lipid levels [8]. Adiponectin is encoded by adipocyte, C1q, and collagen domain containing (ACDC), which is located on chromosome 3 at q27, where genome-wide scans have revealed a susceptibility locus for T2DM, obesity, and metabolic syndrome [9]. One of the most commonly reported variants is the +276 G/T polymorphism in intron 2 [10].…”

Section: Introductionmentioning

confidence: 99%

Adiponectin (+276 G/T), Tumor Necrosis Factor-alpha (-308 G/A) and Interleukin-6 (-174 C/G) Genes Polymorphisms in Egyptian Type 2 Diabetic Patients

Abd-Elbaky¹,

Matty²

2016

J Diabetes Metab

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Type 2 diabetes mellitus (T2DM) is a metabolic pro-inflammatory disorder characterized by chronic hyperglycemia and increased levels of circulating cytokines. Adiponectin, tumor necrosis factor-α (TNF-α), interleukin-6 (Il-6), are important cytokines mediators in the pathogenesis of T2DM. The single nucleotide polymorphisms (SNPs) present in the regulatory regions of cytokine genes often have an impact on their expression levels.Aim: Explore potential associations between SNP+276 G/T of adiponectin, SNP -308 G/A of TNF-α and SNP -174 C/G of IL-6 genes with T2DM and to assess its influence on their serum levels. Subjects and Methods:From the Egyptian population, we enrolled 95 T2DM patients and 85 non-diabetic controls. Serum adiponectin, TNF-α and IL-6 were measured. Genotyping for three SNPs of the adiponectin, TNF-α and IL-6 genes was performed by polymerase chain reaction-restriction fragment length polymorphism.Results: Subjects with the GT/TT genotype of SNP 276 were at increased risk for T2DM (OR=15.88, CI=7.56-33.31, P ≤ 0.01) and associated with hypoadiponectinemia compared with the GG genotype. Furthermore, the allelic frequency of the A allele of SNP 308 was significantly different between T2DM patients compared to controls (X 2 =30.54, P ≤ 0.0001). Moreover, Individuals with T2DM carrying the GA/AA genotypes had significantly higher serum TNF-α levels than those carrying GG genotype. In addition, Carriers of G allele of IL-6 were significantly more likely associated with T2DM.

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Association Between Eight Adiponectin Polymorphisms, Obesity, and Metabolic Syndrome Parameters in Tunisian Volunteers

Abstract: Adiponectin gene polymorphisms were associated with obesity and metabolic syndrome parameters in Tunisian volunteers.

Cited by 22 publications

References 39 publications

Association of the <i>ADIPOQ</i> T45G polymorphism with insulin resistance and blood glucose: A meta-analysis

Association of the <i>ADIPOQ</i> T45G polymorphism with insulin resistance and blood glucose: A meta-analysis

Therapeutic impact of cholecalciferol in patients with psychiatric disorders receiving olanzapine

Adiponectin (+276 G/T), Tumor Necrosis Factor-alpha (-308 G/A) and Interleukin-6 (-174 C/G) Genes Polymorphisms in Egyptian Type 2 Diabetic Patients

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