Association between elevated placental polycyclic aromatic hydrocarbons (PAHs) and PAH-DNA adducts from Superfund sites in Harris County, and increased risk of preterm birth (PTB)

Suter, Melissa; Aagaard, Kjersti M.; Coarfa, Cristian; Robertson, Matthew J.; Zhou, Guodong; Jackson, Brian P.; Thompson, Debbe; Putluri, Vasanta; Putluri, Nagireddy; Hagan, Joseph; Wang, Lihua; Jiang, Weiwu; Lingappan, Krithika; Moorthy, Bhagavatula

doi:10.1016/j.bbrc.2019.06.049

Cited by 40 publications

(21 citation statements)

References 33 publications

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“…A nationwide cohort study in Sweden has suggested that maternal occupational exposure to PAHs significantly increased the risk of LBW (OR:1.49, 95%CI: 1.27, 1.75) [28]. Another study found similar results that placental PAHs levels were negatively associated with birth weight (r: -0.223, P = 0.037) [29]. Choi et al conducted two parallel prospective cohort studies and found that prenatal PAH exposure was significantly associated with reduced birth weight in both Krakow Caucasians (β: -0.02, 95%CI: -0.03372, -0.00628) and New York City (NYC) African Americans (β: -0.055, 95%CI: -0.0942, -0.0158), but not in NYC Dominicans (β: -0.018, 95%CI: -0.00356, 0.03956) [21].…”

Section: Introductionmentioning

confidence: 88%

The association between prenatal exposure to polycyclic aromatic hydrocarbons and birth weight: A meta-analysis

et al. 2020

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Background Polycyclic aromatic hydrocarbons (PAHs) are a kind of endocrine disruptors, which can enter human body by the inhalation of PAH-containing matter and the ingestion of PAH-containing foodstuffs. Studies showed that PAHs can cross the placental barrier and might cause adverse effects on the fetus. Objectives This meta-analysis aimed to estimate the associations between prenatal exposure to PAHs and birth weight. Methods Articles published in English until May 8, 2020 and reported the effects of prenatal exposure to PAHs on birth weight were searched in multiple electronic databases including PubMed, the Web of Science, EMBASE and the Cochrane Library. The included studies were divided into three groups in accordance with the measurement of PAHs exposure. Then coefficient was extracted, conversed and synthesized by random-effects meta-analysis. And risk of bias was assessed for each study. Results A total of 3488 citations were searched and only 11 studies were included finally after double assessment. We found that there were no association between PAH-DNA adducts in cord blood (low/high) (OR: 1.0, 95%CI: 0.97, 1.03), 1-hydroxy pyrene (1-HP) concentration in maternal urine (OR: 1.0, 95%CI: 0.97, 1.03) and prenatal maternal airborne PAHs exposure (OR: 0.97, 95%CI: 0.93, 1.01) and birth weight. However, we observed ethnicity may change the effects of PAHs exposure on birth weight.

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Section: Introductionmentioning

confidence: 88%

The association between prenatal exposure to polycyclic aromatic hydrocarbons and birth weight: A meta-analysis

et al. 2020

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“…The effects of polybrominated diphenyl ether exposure on the placenta and foetus in rats during gestation varied by foetal sex. Moreover, higher concentrations of polycyclic aromatic hydrocarbons such as benzo[a]pyrene, benzo[b]fluorine, and dibenz[a,h]anthracene were found in the placenta of preterm deliveries in comparison to term deliveries [120].…”

Section: Effects Of Environmental Factors On the Placentamentioning

confidence: 99%

Environmental Exposure during Pregnancy: Influence on Prenatal Development and Early Life: A Comprehensive Review

et al. 2021

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Preconception and prenatal exposure to environmental contaminants may affect future health. Pregnancy and early life are critical sensitive windows of susceptibility. The aim of this review was to summarize current evidence on the toxic effects of environment exposure during pregnancy, the neonatal period, and childhood. Alcohol use is related to foetal alcohol spectrum disorders, foetal alcohol syndrome being its most extreme form. Smoking is associated with placental abnormalities, preterm birth, stillbirth, or impaired growth and development, as well as with intellectual impairment, obesity, and cardiovascular diseases later in life. Negative birth outcomes have been linked to the use of drugs of abuse. Pregnant and lactating women are exposed to endocrine-disrupting chemicals and heavy metals present in foodstuffs, which may alter hormones in the body. Prenatal exposure to these compounds has been associated with pre-eclampsia and intrauterine growth restriction, preterm birth, and thyroid function. Metals can accumulate in the placenta, causing foetal growth restriction. Evidence on the effects of air pollutants on pregnancy is constantly growing, for example, preterm birth, foetal growth restriction, increased uterine vascular resistance, impaired placental vascularization, increased gestational diabetes, and reduced telomere length. The advantages of breastfeeding outweigh any risks from contaminants. However, it is important to assess health outcomes of toxic exposures via breastfeeding. Initial studies suggest an association between pre-eclampsia and environmental noise, particularly with early-onset pre-eclampsia. There is rising evidence of the negative effects of environmental contaminants following exposure during pregnancy and breastfeeding, which should be considered a major public health issue.

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“…61 Another study showed that the expression of NRF2 was also significantly decreased in the placenta of preterm delivery patients residing in areas with elevated levels of polycyclic aromatic hydrocarbons. 62 Endocrine disrupting chemicals such as bisphenol A (BPA) and 2,2′4,4′-tetrabromodiphenyl ether (BDE-47) were also shown to affect the expression of Nrf2. Under OS BPA was found to impair NRF2 expression and translocation, which in turn inhibited trophoblast death, thus affecting normal placental development during pregnancy.…”

Section: 26mentioning

confidence: 99%

The role of nuclear factor erythroid 2–related factor 2 (NRF2) in normal and pathological pregnancy: A systematic review

Tantengco

Silva

Shahin

et al. 2021

American J Rep Immunol

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Objective: A homeostatic balance between reactive oxygen species production and the antioxidant redox system is an important component of normal pregnancy. Nuclear Factor Erythroid 2-Related Factor 2 (Nrf2) preserves cellular homeostasis by enhancing the cell's innate antioxidant status to reduce oxidative stress and inflammatory damage to the cell during pregnancy. Active Nrf2, in the nucleus of the cell, transactivates various antioxidant genes. The objective of this systematic review was to synthesize evidence on the role of Nrf2 in various adverse pregnancy outcomes (APOs). Methods:We conducted a systematic review of the role of Nrf2 in pregnancy. Articles written in English, Portuguese, and Spanish were obtained from three different databases from inception until January 2021. The titles, abstracts and full text were reviewed independently by six reviewers. The quality of the included studies was assessed using a quality assessment tool developed to assess basic science and clinical studies. Nrf2 expression (gene and protein), functional contributions, and association with APOs were assessed.Results: A total of 747 citations were identified; 80 were retained for full review.Most studies on Nrf2 have been carried out using placental tissues and placentaderived cells. Limited studies have been conducted using fetal membranes, uterus, and cervix. Nuclear translocation of Nrf2 results in transactivation of antioxidant enzymes, including glutathione peroxidase, hemeoxygenase-1, and superoxide dismutase in gestational cells during pregnancy. This antioxidant response maintains cellular homeostasis during pregnancy. This promotes trophoblast cell survival and prevents cell death and abnormal angiogenesis in the placenta. Excessive and insufficient Nrf2 response may promote oxidative and reductive stress, respectively. This Nrf2 dysregulation has been associated with APOs including gestational diabetes mellitus, intrauterine growth restriction, reproductive toxicity, preeclampsia, and preterm birth. Conclusion:Several studies have localized and reported an association between Nrf2's differential expression in reproductive tissues and the pathogenesis of APOs. However, a comprehensive functional understanding of Nrf2 in reproductive tissues is still

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Association between elevated placental polycyclic aromatic hydrocarbons (PAHs) and PAH-DNA adducts from Superfund sites in Harris County, and increased risk of preterm birth (PTB)

Cited by 40 publications

References 33 publications

The association between prenatal exposure to polycyclic aromatic hydrocarbons and birth weight: A meta-analysis

The association between prenatal exposure to polycyclic aromatic hydrocarbons and birth weight: A meta-analysis

Environmental Exposure during Pregnancy: Influence on Prenatal Development and Early Life: A Comprehensive Review

The role of nuclear factor erythroid 2–related factor 2 (NRF2) in normal and pathological pregnancy: A systematic review

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