Association between Elevated TGA-IgA Titers and Older Age at Diagnosis with Absence of HBV Seroconversion in Celiac Children

Trovato, Chiara Maria; Montuori, Monica; Sansone, Andrea; Morelli, A.; Russo, G; Pietropaoli, Nicoletta; Oliva, Salvatore

doi:10.3390/vaccines9020101

Cited by 3 publications

(1 citation statement)

References 45 publications

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“…-Tanwar y colaboradores (23) 2020 India Pacientes con EC e hipertensión portal 42 2 4,8% contra el VHB se ha demostrado previamente (34) . Trovato y colaboradores (40) evaluó a 96 niños con EC, el 41,7% (n = 40) mostró títulos de anticuerpos no protectores o ausentes contra el VHB. Los valores elevados de tTG-IgA (p=0,023) y una mayor edad en el momento del diagnóstico (p <0,001) se asociaron con una ausencia de seroconversión a la vacuna contra el VHB.…”

Section: Autorunclassified

Hepatitis B and Celiac Disease: a cause for concern?

Narciso-Schiavon,

Schiavon

2023

Rev. colomb. Gastroenterol.

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Some theories suggest that the development of the immune response to clear hepatitis B triggers the intestinal tissue damage seen in celiac disease in genetically predisposed individuals. Although the role of hepatitis B virus infection in the development of autoimmune diseases has been widely discussed in the literature, it remains a controversial topic. Our objective is to review whether there is an association between hepatitis B and celiac disease and the particularities of vaccination against hepatitis B in celiac patients.

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Section: Autorunclassified

Hepatitis B and Celiac Disease: a cause for concern?

Narciso-Schiavon,

Schiavon

2023

Rev. colomb. Gastroenterol.

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A Comprehensive Review of Hepatitis B Vaccine Nonresponse and Associated Risk Factors

Tahir,

Shinkafi,

Alshrari

et al. 2024

Vaccines

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Hepatitis B virus (HBV) infection remains a significant global health concern worldwide, contributing to high rates of mortality and morbidity, including chronic hepatitis B, cirrhosis, and hepatocellular carcinoma (HCC). Universal vaccination programs have significantly reduced the rate of HBV transmission; however, a subset of individuals fail to develop a protective immune response following vaccination and are termed nonresponders. A comprehensive search strategy using the PubMed, Google Scholar, and Web of Science databases was employed to search for relevant studies using keywords including “hepatitis B vaccine”, “vaccine nonresponse”, “immunogenicity”, “immune response to the hepatitis B vaccine”, and “associated risk factors”. Factors influencing the vaccine’s response include demographic factors, such as age and sex, with increased nonresponse rates being observed in older adults and males. Obesity, smoking, and alcohol consumption are lifestyle factors that decrease the vaccine response. Medical conditions, including diabetes, chronic kidney and liver diseases, HIV, celiac disease, and inflammatory bowel disease, affect the vaccine response. Major histocompatibility complex (MHC) haplotypes and genetic polymorphisms linked to immune regulation are genetic factors that further influence the vaccine’s effectiveness. To reduce the global burden of hepatitis B infection, it is essential to understand these factors to improve vaccine effectiveness and develop individualized vaccination strategies.

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Vaccine Efficacy and Safety in Patients with Celiac Disease

Scarmozzino,

Zanoni,

Arcolaci

et al. 2024

Vaccines

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Celiac disease (CD) is an autoimmune disorder caused by gluten intake in genetically predisposed individuals. This article provides an overview of the available data on the risks of infectious diseases and the mechanisms involved in CD, including a detailed analysis of vaccine efficacy, immunogenicity, and safety. The published articles were retrieved from the PubMed database using the terms “celiac disease,” “efficacy,” “hyposplenism,” “immune response,” “infections,” “immunization,” “immunogenicity,” “safety,” “vaccination,” and “vaccine.” CD can be associated with several autoimmune diseases, including selective immunoglobulin A deficiency (SIgAD), altered mucosal permeability, and hyposplenism. These conditions entail an increased risk of infections, which can be prevented by targeted vaccinations, although specific recommendations on immunization practices for subjects with CD have not been released. Regarding vaccinations, the immune response to the Hepatitis B virus (HBV) vaccine can be impaired in patients with CD; therefore, proposed strategies to elicit and maintain protective specific antibody titers are summarized. For patients with conditions that put them at risk of infections, vaccinations against Pneumococcus and other encapsulated bacteria should be recommended. Based on the available evidence, the Rotavirus vaccine offered to children could be useful in preventing CD in at-risk subjects. Overall, except for the HBV vaccine, vaccine efficacy in patients with CD is comparable to that in the general population, and no safety concerns have arisen.

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Association between Elevated TGA-IgA Titers and Older Age at Diagnosis with Absence of HBV Seroconversion in Celiac Children

Cited by 3 publications

References 45 publications

Hepatitis B and Celiac Disease: a cause for concern?

Hepatitis B and Celiac Disease: a cause for concern?

A Comprehensive Review of Hepatitis B Vaccine Nonresponse and Associated Risk Factors

Vaccine Efficacy and Safety in Patients with Celiac Disease

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