Association between endometriosis and metabolic syndrome: a cross-sectional study based on the National Health and Nutrition Examination Survey data

Li, Baijia; Zhang, Yuxue; Zhang, Liuhang; Zhang, Lingyan

doi:10.1080/09513590.2023.2254844

Cited by 13 publications

(6 citation statements)

References 24 publications

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“…Elevated levels of triglycerides have been associated with obesity, insulin resistance, and metabolic syndrome, all of which are risk factors for endometriosis. Studies have shown a potential link between high levels of triglycerides and an increased risk of developing endometriosis or experiencing more severe symptoms [56,57]. Adipose tissue is an active endocrine organ that secretes various adipokines and inflammatory mediators, which can promote inflammation and affect hormone levels, potentially contributing to the development and progression of endometriosis [58] Moreover, insulin resistance, which is associated with high triglyceride levels, may also play a role in the pathogenesis of endometriosis [59,60].…”

Section: Discussionmentioning

confidence: 99%

Diagnostic Value of Menstrual Blood Lipidomics in Endometriosis: A Pilot Study

Starodubtseva,

Chagovets,

Tokareva

et al. 2024

Preprint

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Endometriosis is a prevalent chronic inflammatory disease characterized by a considerable delay between initial symptoms and diagnosis through surgery. The pressing need for a timely, non-invasive diagnostic solution underscores the focus of current research efforts. This study examines the diagnostic potential of the menstrual blood lipidome. The lipid profile of 39 samples (23 women with endometriosis and 16 patient of control group) was acquired using reverse-phase high-performance liquid chromatography-mass spectrometry with LipidMatch processing and identification. Profiles were normalized based on total ion counts. Significant differences in lipids were determined using the Mann-Whitney test. Lipids for the diagnostic model, based on logistic regression, were selected using a combination of variance importance projection filters and Akaike information criteria. Levels of ceramides, sphingomyelins, cardiolipins, triacylglycerols, acyl- and alkenyl-phosphatidylethanolamines, and alkenyl-phosphatidylcholines increased, while acyl- and alkyl-phosphatidylcholines decreased in cases of endometriosis. PE P-16:0/18:1 and CL 16:0_18:0_22:5_22:6 serve as marker lipids in the diagnostic model, exhibiting a sensitivity of 81% and specificity of 85%. The diagnostic approach based on dried spots of menstrual blood holds promise as an alternative to traditional non-invasive methods for endometriosis screening.

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Section: Discussionmentioning

confidence: 99%

Diagnostic Value of Menstrual Blood Lipidomics in Endometriosis: A Pilot Study

Starodubtseva,

Chagovets,

Tokareva

et al. 2024

Preprint

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“…As a multifactorial and systemic disease, endometriosis is caused by many factors and the exact pathogenesis has not been clearly explained (5). Recently, metabolic abnormalities, including dyslipidemia and glucose metabolism dysfunction, were reported to be an increasingly significant etiology of endometriosis, with the development of metabolomics technology (6)(7)(8)(9).…”

Section: Discussionmentioning

confidence: 99%

“…Recently, emerging evidence suggests that metabolic disturbances play a vital role in the development and progression of endometriosis (5,6). In particular, dysregulation of glucose and lipid metabolism has been observed in women with endometriosis (7)(8)(9).…”

Section: Introductionmentioning

confidence: 99%

Association between triglyceride-glucose index and risk of endometriosis in US population: results from the national health and nutrition examination survey (1999–2006)

Liu,

Wang,

et al. 2024

Front. Endocrinol.

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Background and AimsThe association of the triglyceride-glucose (TyG) index, a promising novel biomarker for insulin resistance, with the risk of endometriosis has not been investigated to date. This nationwide study aimed to explore the association between the TyG index and the endometriosis risk.MethodsData were obtained from the National Health and Nutrition Examination Survey (1999–2006). Female participants who provided complete data on the TyG index and endometriosis were enrolled in the analysis. Multivariate logistic regression analyses were utilized to assess the association of the TyG index with endometriosis, adjusted by multiple potential confounders. Meanwhile, in-depth subgroup analyses were conducted.ResultsA total of 1,590 eligible participants were included, among whom 135 (8.5%) women were diagnosed with endometriosis. The fully adjusted multivariate logistic model showed TyG index was significantly associated with the endometriosis risk (odds ratio [OR]Q4 versus Q1 2.04, 95% confidence interval [CI]: 1.15–3.62; P for trend=0.013). In subgroup analyses, the significantly positive association between TyG index and the risk of endometriosis was also found in parous women (ORQ4 versus Q1 2.18, 95% CI: 1.20–3.96), women without diabetes (OR Q4 versus Q1 2.12, 95% CI: 1.19–3.79), women who smoke currently (OR Q4 versus Q1 3.93, 95% CI: 1.33–11.58), women who drink currently (OR Q4 versus Q1 2.54, 95% CI: 1.27–5.07), and in women who use oral contraceptives (OR Q4 versus Q1 1.91, 95% CI: 1.04–3.51). Additionally, significantly increasing trends in the odds of endometriosis across the quartiles of the TyG index were observed in the above-mentioned subgroups (all P for trend<0.05).ConclusionsThis population-based study found that a higher TyG index, representing an increased level of insulin resistance, was associated with a higher risk of endometriosis among the US population. Our findings suggested TyG index might be a promising tool for the risk assessment of endometriosis. Prospective studies are warranted to further verify these findings.

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“…Abnormalities in lipid metabolism can affect hormonal balance and may indirectly influence the growth and function of the endometrium by modulating inflammatory responses and immune functions [6]. A substantial body of evidence from previous studies suggests a correlation between serum lipid levels and an increased incidence of EMS [7][8][9][10][11]. However, most of these observed associations are based on observational designs, and their causal relationships have not been fully established.…”

Section: Introductionmentioning

confidence: 99%

Genetic association of serum lipids and lipid-modifying targets with endometriosis: Trans-ethnic Mendelian-randomization and mediation analysis

Zhang,

Fan,

et al. 2024

PLoS ONE

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Background Prior observational research identified dyslipidemia as a risk factor for endometriosis (EMS) but the causal relationship remains unestablished due to inherent study limitations. Methods Genome-wide association study data for high-density lipoprotein cholesterol (HDL-C), low-density lipoprotein cholesterol (LDL-C), triglycerides (TG), and total cholesterol (TC) from European (EUR) and East Asian (EAS) ancestries were sourced from the Global Lipids Genetics Consortium. Multi-ancestry EMS data came from various datasets. Univariable Mendelian randomization (MR) examined causal links between serum lipids and EMS. Multivariable and mediation MR explored the influence of seven confounding factors and mediators. Drug-target MR investigates the association between lipid-lowering target genes identified in positive results and EMS. The primary method was inverse-variance weighted (IVW), with replication datasets and meta-analyses reinforcing causal associations. Sensitivity analyses included false discovery rate (FDR) correction, causal analysis using summary effect estimates (CAUSE), and colocalization analysis. Results IVW analysis in EUR ancestry showed a significant causal association between TG and increased EMS risk (OR = 1.112, 95% CI 1.033–1.198, P = 5.03×10−3, PFDR = 0.03), supported by replication and meta-analyses. CAUSE analysis confirmed unbiased results (P < 0.05). Multivariable and mediation MR revealed that systolic blood pressure (Mediation effect: 7.52%, P = 0.02) and total testosterone (Mediation effect: 10.79%, P = 0.01) partly mediated this relationship. No causal links were found between other lipid traits and EMS (P > 0.05 & PFDR > 0.05). In EAS ancestry, no causal relationships with EMS were detected (P > 0.05 & PFDR > 0.05). Drug-target MR indicated suggestive evidence for the influence of ANGPTL3 on EMS mediated through TG (OR = 0.798, 95% CI 0.670–0.951, P = 0.01, PFDR = 0.04, PP.H4 = 0.85%). Conclusions This MR study in EUR ancestry indicated an increased EMS risk with higher serum TG levels.

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Association between endometriosis and metabolic syndrome: a cross-sectional study based on the National Health and Nutrition Examination Survey data

Cited by 13 publications

References 24 publications

Diagnostic Value of Menstrual Blood Lipidomics in Endometriosis: A Pilot Study

Diagnostic Value of Menstrual Blood Lipidomics in Endometriosis: A Pilot Study

Association between triglyceride-glucose index and risk of endometriosis in US population: results from the national health and nutrition examination survey (1999–2006)

Genetic association of serum lipids and lipid-modifying targets with endometriosis: Trans-ethnic Mendelian-randomization and mediation analysis

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