Association between erythrocyte concentrations of magnesium and zinc in high-performance handball players after dietary magnesium supplementation

Molina-López, Jorge; Molina, José Molina; Chirosa, Luís Javier; Florea, Daniela; Sáez, Laura; Millán, E.; Planells, Elena

doi:10.1684/mrh.2012.0311

Cited by 15 publications

(9 citation statements)

References 28 publications

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“…Exercise is known to effect Mg metabolism and there is an alternating response, depending on exercise intensity [107,109,110]. In elite handball athletes, greater time spent exercising at low-to-moderate intensity was associated with higher plasma Mg levels, whereas a greater time spent training at >80% residual heart rate was associated with lower Mg levels ( r = 0.38, p < 0.01; [109]). Intense training over four weeks similarly resulted in lower Mg levels in elite volleyball players, including in those supplementing with Mg [107].…”

Section: Discussionmentioning

confidence: 99%

The Role of Mineral and Trace Element Supplementation in Exercise and Athletic Performance: A Systematic Review

et al. 2019

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Minerals and trace elements (MTEs) are micronutrients involved in hundreds of biological processes. Deficiency in MTEs can negatively affect athletic performance. Approximately 50% of athletes have reported consuming some form of micronutrient supplement; however, there is limited data confirming their efficacy for improving performance. The aim of this study was to systematically review the role of MTEs in exercise and athletic performance. Six electronic databases and grey literature sources (MEDLINE; EMBASE; CINAHL and SportDISCUS; Web of Science and clinicaltrials.gov) were searched, in accordance with PRISMA guidelines. Results: 17,433 articles were identified and 130 experiments from 128 studies were included. Retrieved articles included Iron (n = 29), Calcium (n = 11), Magnesium, (n = 22), Phosphate (n = 17), Zinc (n = 9), Sodium (n = 15), Boron (n = 4), Selenium (n = 5), Chromium (n = 12) and multi-mineral articles (n = 5). No relevant articles were identified for Copper, Manganese, Iodine, Nickel, Fluoride or Cobalt. Only Iron and Magnesium included articles of sufficient quality to be assigned as ‘strong’. Currently, there is little evidence to support the use of MTE supplementation to improve physiological markers of athletic performance, with the possible exception of Iron (in particular, biological situations) and Magnesium as these currently have the strongest quality evidence. Regardless, some MTEs may possess the potential to improve athletic performance, but more high quality research is required before support for these MTEs can be given. PROSPERO preregistered (CRD42018090502).

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Section: Discussionmentioning

confidence: 99%

The Role of Mineral and Trace Element Supplementation in Exercise and Athletic Performance: A Systematic Review

et al. 2019

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“…The concentration of mineral elements is usually under strict homeostatic control; however, physical activity alters this mechanism and brings changes in their serum levels [1][2][3][4]. Some studies report on the mineral concentrations in plasma, serum and urine.…”

Section: Introductionmentioning

confidence: 99%

Influence of physical training on erythrocyte concentrations of iron, phosphorus and magnesium

Mariño

Grijota

Bartolomé

et al. 2020

Journal of the International Society of Sports Nutrition

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Background: The present study aimed to determine changes occurring in the erythrocyte concentrations of Iron (Fe), Magnesium (Mg) and Phosphorous (P) of subjects with different levels of physical training living in the same area of Extremadura (Spain). Methods: Thirty sedentary subjects (24.34 ± 3.02 years) without sports practice and a less active lifestyle, formed the control group (CG); 24 non-professional subjects (23.53 ± 1.85 years), who perform between 4 and 6 h/week of moderate sports practice without any performance objective and without following systematic training formed the group of subjects with a moderate level of training (MTG), and 22 professional cyclists (23.29 ± 2.73 years) at the beginning of their sports season, who performed more than 20 h/week of training, formed the high-level training group (HTG). Erythrocyte samples from all subjects were collected and frozen at − 80°C until analysis. Erythrocyte analysis of Fe, Mg and P was performed by inductively coupled plasma mass spectrometry (ICP-MS). All results are expressed in μg/g Hb. Results: The results showed that there were statistically significant lower concentrations of erythrocyte Fe, Mg and P in MTG and HTG than CG. All parameters (Fe, Mg and P concentrations in erythrocytes) correlated inversely with physical training. Conclusions: Physical exercise produces a decrease in erythrocyte concentrations of Fe, Mg and P. This situation could cause alterations in the performance of athletes given the importance of these elements. For this reason, we recommend an erythrocyte control at the beginning, and during the training period, to avoid harmful deficits.

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“…The latter finding was not statistically significant, which may be attributed to the small sample size of only four horses in our study. Nonetheless, Molina-López et al did also not report a significant change in intra-erythrocyte magnesium concentration after 2 months of magnesium supplementation (100 mg Mg 2+ as MgO) in 14 professional handball-players (Molina-Lopez et al 2012). It may thus appear that the intracellular magnesium concentration is little affected by changes in extracellular magnesium availability in healthy subjects.…”

Section: Discussionmentioning

confidence: 92%

Dose-dependent effects of magnesium supplementation on serum and intracellular magnesium concentrations in healthy horses

Stöckle¹,

Müller²,

Winter³

et al. 2019

PHK

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For magnesium supplementation in horses, dosages for MgO, MgCO3, and MgSO₄ were described previously. However, for magnesium as magnesiumaspartate-hydrochloride (MAH) dose-dependent effects on the magnesium levels have not yet been determined in horses. Therefore, the magnesium concentrations in blood lymphocytes, serum, urine and the fractional magnesium excretion in the urine were measured in five healthy adult horses before and after oral supplementation with 15, 30 and 60 mg/kg bodyweight (BW) magnesium as MAH respectively for seven days. There was no wash-out period in between experimental periods. In erythrocytes, the intracellular baseline magnesium concentration and the intracellular magnesium concentration after one week of supplementation with 60 mg/kg BW magnesium were determined. All horses were exclusively fed with hay of which the magnesium concentration was measured each week. All horses were clinically examined daily, including signs of colic and soft feces. There were no significant changes in the magnesium concentration in the diet. Signs of colic, soft feces or other side effects were not observed. The serum magnesium concentration after supplementation with 60 mg/kg BW magnesium as MAH was significantly higher than the baseline and exceeded the reference range in four of five horses. After 15 and 30 mg/ kg BW magnesium as MAH, the serum magnesium concentration showed a significant increase over time. Neither a significant increase of the intracellular magnesium concentration nor significant changes in urine magnesium concentration or fractional excretion were observed. In erythrocytes, a trend for higher magnesium concentrations was found after supplementation with 60 mg/kg BW magnesium as MAH. For short-term supplementation in cases of increased magnesium requirements, these dosages seem effective and the dosages of 15 mg/kg BW and 30 mg/kg BW safe to use. For supplementation with 60 mg/kg magnesium as MAH, veterinary supervision and monitoring of the serum magnesium concentration is recommended.

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Association between erythrocyte concentrations of magnesium and zinc in high-performance handball players after dietary magnesium supplementation

Cited by 15 publications

References 28 publications

The Role of Mineral and Trace Element Supplementation in Exercise and Athletic Performance: A Systematic Review

The Role of Mineral and Trace Element Supplementation in Exercise and Athletic Performance: A Systematic Review

Influence of physical training on erythrocyte concentrations of iron, phosphorus and magnesium

Dose-dependent effects of magnesium supplementation on serum and intracellular magnesium concentrations in healthy horses

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