Вісник проблем біології і медицини -2023 -Вип. 3 (170) / Bulletin of problems in biology and medicine -2023 -Issue 3 (170)
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СТОМАТОЛОГІЯ / DENTISTRYThe purpose of the study: to investigate the clinical manifestations of exudative erythema multiforme associated with the herpes simplex virus in an 11-year-old child; to develop a scheme of complex treatment of this disease. Object and research methods. A clinical and laboratory examination of an 11-year-old child with a diagnosis of exudative erythema multiforme associated with the herpes simplex virus was carried out. During the clinical dental examination of the mucous membrane of the oral cavity, we evaluated its color, localization, number, dynamics of the lesion elements, as well as the involvement of other anatomical areas in the process; analyzed signs and nature of general intoxication (temperature reaction, presence and duration of regional lymphadenitis). The anamnesis data were taken into account: the frequency of disease relapses, the presence of concomitant and transferred diseases. Additional laboratory research methods are prescribed: clinical blood test, immunological blood test for the determination of IgE class antibodies; immunoenzymatic blood analysis for specific IgM, IgG to the herpes simplex virus with determination of the avidity index; PCR study of oral fluid for herpes simplex virus. Research results. A scheme of complex treatment of exudative erythema multiforme associated with the herpes simplex virus with the use of a helium-neon laser has been developed. Clinical control of the effectiveness of the proposed treatment scheme was carried out by assessing the dynamics of the main clinical symptoms of the disease: duration of the inflammatory process in the oral cavity, epithelization of the lesion elements. Conclusions. A exudative erythema multiforme was diagnosed in an 11-year-old child, which developed against the background of activation of the herpetic process in the oral cavity and around the mouth, which was confirmed by clinical and laboratory research data. Our proposed scheme of complex treatment with the use of a helium-neon laser contributed to a significant reduction of the clinical manifestation of the disease, namely: a significant reduction of the painful red border of the lips on the third day of treatment, acceleration of epithelization processes -on the fifth day of treatment. When establishing the diagnosis of EEM, it is necessary to take into account the allergic history, previously prescribed drugs, as well as conduct diagnostic tests for herpes virus infection in order to prescribe rational therapy.