2017
DOI: 10.1016/j.ensci.2017.03.002
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Association between exercise habits and subcortical gray matter volumes in healthy elderly people: A population-based study in Japan

Abstract: Background and aimsThe relationship between exercise and subcortical gray matter volume is not well understood in the elderly population, although reports indicate that exercise may prevent cortical gray matter atrophy. To elucidate this association in the elderly, we measured subcortical gray matter volume and correlated this with volumes to exercise habits in a community-based cohort study in Japan.MethodsSubjects without mild cognitive impairment or dementia (n = 280, 35% male, mean age 73.1 ± 5.9 years) we… Show more

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Cited by 13 publications
(17 citation statements)
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“…A Japanese study on healthy elders demonstrated a meaningful result, with larger volumes of left hippocampus and bilateral nucleus accumbens in those exposed to frequent exercise habits. 46 Our study results are in line with the aforementioned result, and disparities in the subcortical volumes of the two groups in our study suggest the beneficial effects of exercise not only impact cortical structures, but also core subcortical structures in preclinical AD patients.…”
Section: Discussionsupporting
confidence: 92%
“…A Japanese study on healthy elders demonstrated a meaningful result, with larger volumes of left hippocampus and bilateral nucleus accumbens in those exposed to frequent exercise habits. 46 Our study results are in line with the aforementioned result, and disparities in the subcortical volumes of the two groups in our study suggest the beneficial effects of exercise not only impact cortical structures, but also core subcortical structures in preclinical AD patients.…”
Section: Discussionsupporting
confidence: 92%
“…Asymmetries from the controls and depressions were similar to each other, and the left hemisphere asymmetry prevailed in cortical areas. These findings were consistent with the previous studies [ 62 - 65 ]. However, when comparing the left and right hemisphere asymmetry between groups, no statistically significant difference was found (FDR p>0.2).…”
Section: Discussionsupporting
confidence: 94%
“…As outlined previously, different lines of evidence demonstrate the positive effect of exercise on cognitive function and risk of dementia [10][11][12][13][14][15][16][18][19][20][21][22][23][24][25][26][27][28][29][30][31][32][33][34]. However, the biological mechanisms by which this effect may be mediated remain to be clarified.…”
Section: Discussionmentioning
confidence: 99%
“…In humans, most of the studies have focused on exercise and hippocampal volume [17]. Results have been divergent, although most studies have shown a lack of association in both intervention [18][19][20][21][22] and observational studies [23][24][25][26][27][28]. There have been discrepancies in results from observational studies examining the association between Ab or tau and physical activity [29][30][31][32][33][34].…”
Section: Introductionmentioning
confidence: 99%