Association between exercise intensity and renal blood flow evaluated using ultrasound echo

Kawakami, Shotaro; Yasuno, Tetsuhiko; Matsuda, Takehisa; Fujimi, Kanta; Ito, Ai; Yoshimura, S.; Uehara, Yoshio; Tanaka, Hiroaki; Saito, Takao; Higaki, Yasuki

doi:10.1007/s10157-018-1559-1

Cited by 31 publications

(37 citation statements)

References 31 publications

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“…Firstly, the transient decrease in peritubular capillary blood flow due to the reduction in renal blood flow induced by the exercise after the lactate acid breaking point may be associated with the increase in urinary L‐FABP excretion. This is because the previous study reported that the decreases in renal blood flow due to the exercise were induced after the lactate acid breaking point . Secondly, the post‐exercise albuminuria is also likely to be associated with the increase in urinary L‐FABP excretion.…”

Section: Discussionmentioning

confidence: 98%

“…This is because the previous study reported that the decreases in renal blood flow due to the exercise were induced after the lactate acid breaking point. 6 Secondly, the post-exercise albuminuria is also likely to be associated with the increase in urinary L-FABP excretion. The human L-FABPs gene expression and its urinary excretion have been reported to be increased by the protein overload in the proximal tubules.…”

Section: Discussionmentioning

confidence: 99%

“…blood flow redistribution, incremental short maximal exercise, liver-type fatty acid-binding protein, peritubular capillary blood flow, tubular biomarker Significant redistribution of tissue blood flow, which greatly increases blood flow to the active muscles and decreases splanchnic blood flow such as kidney in an exercise intensity-dependent manner, is generally known as exercise physiological response. 2 Actually, previous animal 3,4 and human 5,6 studies have demonstrated that renal blood flow was decreased by the high-intensity exercise. Although the reduction in renal blood flow by the high-intensity exercise is likely to be transient, the kidney is vulnerable to hypoperfusion and hypoxia, and therefore, may be affected by renal hypoxia due to the high-intensity exercise.…”

Section: Introductionmentioning

confidence: 99%

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Incremental short maximal exercise increases urinary liver‐type fatty acid‐binding protein in adults without CKD

Kosaki

Kamijo‐Ikemori

Sugaya

et al. 2020

Scandinavian Med Sci Sports

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Exercise‐induced redistribution of tissue blood flow decreases the renal blood flow in an exercise intensity‐dependent manner. However, the acute effects of incremental short maximal exercise on renal tubular conditions remain unknown. The purpose of this study was to investigate the acute effects of incremental short maximal exercise on the urinary liver‐type fatty acid‐binding protein, which is a highly sensitive tubular biomarker that correlates excellently with peritubular capillary blood flow. A total of 116 adults (aged 24‐83 years) without chronic kidney disease performed the incremental short maximal exercise using a cycling ergometer, wherein the exercise sequence consisted of commencing with a 2‐min workout period at 20 W (as a warm‐up period) and then followed by a 10‐20 W increase every 1 minute until termination criteria were reached. Urinary samples were gathered before and immediately after the exercise to evaluate the concentrations of urinary creatinine, albumin, and liver‐type fatty acid‐binding protein. Urinary excretion levels of albumin and liver‐type fatty acid‐binding protein were significantly increased post‐exercise (P < .001 and P = .008, respectively). Furthermore, the % change in urinary liver‐type fatty acid‐binding protein levels after exercise was found to correlate independently with age, estimated glomerular filtration rate at baseline, and the % change in urinary albumin (Model R2 = 0.451, P < .001). Our findings suggest that incremental short maximal exercise may lead to acute slightly adverse effects on tubular conditions, especially in young adults or adults with lower renal function, even without chronic kidney disease.

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Section: Discussionmentioning

confidence: 98%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Incremental short maximal exercise increases urinary liver‐type fatty acid‐binding protein in adults without CKD

Kosaki

Kamijo‐Ikemori

Sugaya

et al. 2020

Scandinavian Med Sci Sports

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“…The left UUO-treated kidney was observed using an ultrasound imaging system (Vevo2100; Fujifilm VisualSonics, Toronto, ON, Canada) on day 7. Left renal artery (RA) blood flow was estimated from velocity time integral (VTI), and left renal artery diameter (RAD) was calculated by PW-Doppler echo using Equation 2 38 : Statistical Analyses Two-group differences were analyzed by an unpaired t test.…”

Section: Ultrasonographymentioning

confidence: 99%

Hepatocyte Growth Factor–Secreting Mesothelial Cell Sheets Suppress Progressive Fibrosis in a Rat Model of CKD

Oka

Sekiya²,

Sakiyama

et al. 2019

JASN

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Background Although hepatocyte growth factor (HGF) has antifibrotic effects and is involved in angiogenesis and vasodilation, systemic administration of HGF to prevent kidney fibrosis is not a feasible strategy for suppressing interstitial fibrosis in patients with CKD. Methods We investigated a novel therapy involving HGF transgenic cell sheets grown in culture from human mesothelial cells and administered to rats with unilateral ureteral obstruction (UUO). We compared progression of fibrosis in rats with UUO that received one of five interventions: HGF-transgenic mesothelial cell sheets transplanted to the kidney surface, HGF-transgenic mesothelial cell sheets transplanted to thigh, mesotherial cell sheets transplanted to kidney, no sheets, or HGF injections. Results HGF transgenic cell sheets transplanted to the kidney strongly suppressed the induction of myofibroblasts and collagen in the kidney for 28 days; other interventions did not. Additionally, the HGF-secreting cell sheets ameliorated loss of peritubular capillaries and maintained renal blood flow. Conclusions These findings suggest that cell sheet therapy is a novel and promising strategy for inhibiting progressive fibrosis in CKD.

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“…A previous review [38] reported that exercise could induce kidney damage, especially high-intensity exercise. Recently, some studies [39,40] suggested that the risk of kidney damage increases only when the exercise intensity exceeded the lactic acid threshold. However, no adverse events related to exercise were reported in any of the included trials.…”

Section: Different Exercise Intensities and Proteinuriamentioning

confidence: 99%

Effects of exercise training on proteinuria in adult patients with chronic kidney disease: a systematic review and meta-analysis

Yang

Wang

et al. 2020

BMC Nephrol

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Background: Rehabilitation effects of exercise training on adults with chronic kidney disease (CKD) have been generally recognised; however, the effects of exercise training on proteinuria have been underexplored. Our aim was to explore the effects of exercise training on proteinuria in adult CKD patients without renal replacement therapy. Methods: Randomised controlled trials (RCTs) and quasi-experimental studies examining the effects of exercise training on proteinuria in adults CKD patients without renal replacement therapy were searched in 10 electronic databases (MEDLINE, Embase, CINAHL, Cochrane Central Register of Controlled Trials, Allied and Complementary Medicine Database, SPORTDiscus with full text, Web of Science, China Wan Fang Database, China National Knowledge Internet, China Science and Technology Journal Database) until June 2019. The quality of quasiexperimental studies was assessed using the Joanna Briggs Institute Checklist for non-randomised experimental studies. The Cochrane risk of bias tool was used to evaluate the RCT quality. Results: We analysed 11 studies (623 participants). The 24-h urinary protein (24 h UP) level significantly decreased after exercise training in the within-group analysis (standard mean difference [SMD], 0.48; 95% confidence interval [CI], 0.08 to 0.88). There was a slight decrease in 24 h UP levels in the between-group analysis (SMD, 0.91; 95% CI, 0.00 to 1.82); however, the subgroup analysis showed that the change was insignificant (RCT: SMD, 0.24; 95% CI, − 0.44 to 0.92; quasi-experimental studies: SMD, 2.50; 95% CI, − 1.22 to 6.23). Exercise resulted in no significant differences in the urinary albumin-to-creatinine ratio in the between-group analysis (SMD, 0.06; 95% CI, − 0.54 to 0.67), but a significant decrease was found in the within-group analysis (SMD, 0.21; 95% CI, 0.04 to 0.38). No evidence of a decreased urinary protein-to-creatinine ratio was found after exercise (between-group analysis: SMD, 0.08 and 95% CI, − 0.33 to 0.48; within-group analysis: SMD, 0.04; 95% CI, − 0.25 to 0.32). Conclusion: Exercise training does not aggravate proteinuria in adult CKD patients without renal replacement therapy. Further research is warranted in the future to determine the effectiveness of exercise training on proteinuria and to explore the mechanisms by which exercise training influences proteinuria.

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Association between exercise intensity and renal blood flow evaluated using ultrasound echo

Abstract: RBF showed no significant decrease until 80% LaBP, and decreased with an increase in blood lactate. Reduction in RBF with exercise above the intensity at LaBP was due to decreased cross-sectional area rather than time-averaged flow velocity.

Cited by 31 publications

References 31 publications

Incremental short maximal exercise increases urinary liver‐type fatty acid‐binding protein in adults without CKD

Incremental short maximal exercise increases urinary liver‐type fatty acid‐binding protein in adults without CKD

Hepatocyte Growth Factor–Secreting Mesothelial Cell Sheets Suppress Progressive Fibrosis in a Rat Model of CKD

Effects of exercise training on proteinuria in adult patients with chronic kidney disease: a systematic review and meta-analysis

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