Association between exposure to organophosphorus pesticides and the risk of diabetes among US Adults: Cross-sectional findings from the National Health and Nutrition Examination Survey

Guo, Xianwei; Wang, Hao; Song, Qiuxia; Li, Ning; Liang, Qiwei; Su, Wei; Liang, Mingming; Ding, Xiuxiu; Sun, Chenyu; Lowe, Scott; Sun, Yehuan

doi:10.1016/j.chemosphere.2022.134471

Cited by 45 publications

(11 citation statements)

References 62 publications

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“…The presence of gout was determined based on the self-reported answer to the question “Has a doctor or other health professional ever told you that you have gout?”. Diabetes was defined as a fasting plasma glucose level of ≥7.0 mmol/L, a glycohemoglobin level of ≥6.5%, the use of diabetes medication or insulin, or a self-reported diagnosis of diabetes [ 19 ]. Hypertension was defined as a mean systolic blood pressure of ≥130 mmHg, a mean diastolic blood pressure of ≥80 mmHg, having a self-reported hypertension diagnosis, or using an antihypertensive drug [ 20 ].…”

Section: Methodsmentioning

confidence: 99%

Association of Visceral Fat Area and Hyperuricemia in Non-Obese US Adults: A Cross-Sectional Study

Gao

Zhong

et al. 2022

Nutrients

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This study aimed to investigate the relationship between visceral fat area (VFA) and hyperuricemia (HUA) among non-obese adults. We extracted data from 6224 US adults aged 20–59 years from the National Health and Nutrition Examination Survey (NHANES) from 2011–2018. The VFA was divided into four quartiles (Q1–Q4). We used multivariable logistic regression models to control for known confounders. A generalized additive model (GAM) and restricted cubic spines were used to examine the association between VFA and HUA stratified by sex, and a two-piecewise linear regression model was used to calculate the threshold effect among males. The results revealed that the prevalence of HUA was 11.8% (men 15.8%, women 7.2%). In the fully adjusted model, there was a positive association between VFA and HUA [as a quartile variable, Q4 vs. Q1, odds ratio (OR): 3.77 and 95% confidence interval (CI): (2.47~5.75), p < 0.001, p for trend < 0.001; as a continuous variable, per 10 cm2 increment, OR (95%CI):1.10(1.07,1.14), p < 0.001]. Besides, this positive association remained significantly stratified by sex. Interestingly, we observed a nonlinear dose-response relationship between VFA and HUA in males (inflection point: 107.46 cm2). In conclusion, our study confirmed a significant positive relationship between VFA and HUA among non-obese adults and remained statistically significant when stratified by sex.

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Section: Methodsmentioning

confidence: 99%

Association of Visceral Fat Area and Hyperuricemia in Non-Obese US Adults: A Cross-Sectional Study

Gao

Zhong

et al. 2022

Nutrients

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“…Besides, more evidence illustrated that OPs were also associated with diseases of the reproductive system (such as decreased sperm counts and motility and altered reproductive hormone levels), 7,8 the nervous system (such as Parkinson's disease) 6,9 and tumours (such as breast cancer) 10 . In addition, OPs were also related to type 2 diabetes, and cardiometabolic diseases in published studies 11,12 …”

Section: Introductionmentioning

confidence: 99%

“…10 In addition, OPs were also related to type 2 diabetes, and cardiometabolic diseases in published studies. 11,12 Organophosphate pesticides could disturb physiological and biochemical functions, and the detoxification of OPs has been studied in a number of studies. 5,13 Publications based on animals have demonstrated that OPs caused liver injury of experimental animals through the production of free radicals that damage all biomolecules of the cell, alteration of the mitochondrial respiration or by redox cycling properties.…”

Section: Introductionmentioning

confidence: 99%

Organophosphate pesticide exposure and biomarkers of liver injury/liver function

Xiao

et al. 2022

Liver International

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Background and Aims There is little epidemiological evidence linking the exposure of organophosphate pesticides (OPs) to liver function or liver injury in the general population. We used data from the National Health and Nutrition Examination Survey 1999–2012 to investigate the relationship of urinary OPs with biomarkers of liver function/liver injury. Methods The exposures were the concentrations of urinary OP metabolites (dimethyl phosphate [DMP], dimethyl thiophosphate [DMTP], diethyl phosphate [DEP] and diethyl thiophosphate [DETP]). The health outcomes were biomarkers of liver function/liver injury. The multivariable linear regression model, restricted cubic splines (RCSs) analysis and weighted quantile sum (WQS) regression were used to evaluate the relationship between individual or overall exposure of OPs and outcomes. Results Regressions of RCSs suggested linear and positive associations of OP metabolites with aspartate aminotransferase/alanine aminotransferase (AST/ALT) ratio (DMP and DEP) and fibrosis‐4 (FIB‐4) index (DMP, DEP and DMTP) (all p–non‐linear values >.05). However, L‐shaped relationships were found between OP metabolites (DMTP and DETP) and blood albumin and total protein (TP) concentrations (both p and non‐linear values <.05). The positive associations of urinary DMP, DEP and DMTP with AST/ALT ratio, and with FIB‐4 score were more pronounced among non‐smokers than smokers, among alcohol drinkers than non‐drinkers and among those with a body mass index (BMI) of ≥25 than participants with a BMI of <25. However, most of the interaction p values were more than .05, indicating no significant interactions between covariates and OPs on outcomes mainly including AST/ALT, FIB‐4, ALB and TP levels. Finally, the WQS indices were positively associated with AST/ALT ratio (p = .014) and FIB‐4 score (p = .002). Conclusions Our study added novel evidence that exposures to OPs might be adversely associated with the biomarkers of liver function/liver injury. These findings indicated the potential toxic effect of OP exposures on the human liver.

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“…Cross-sectional studies in adult populations have established a positive relationship between exposure to pesticides and T2D, insulin resistance and dyslipidemia in several countries, such as Algeria [ 125 ], India [ 126 ], China [ 127 ], South Korea [ 128 ], Canada [ 129 ], and the US [ 130 , 131 ].…”

Section: Immune-mediated Inflammatory Disease Development Is Enhanced...mentioning

confidence: 99%

Pesticides and Their Impairing Effects on Epithelial Barrier Integrity, Dysbiosis, Disruption of the AhR Signaling Pathway and Development of Immune-Mediated Inflammatory Diseases

Lima

Falcão

Rosa

et al. 2022

IJMS

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The environmental and occupational risk we confront from agricultural chemicals increases as their presence in natural habitats rises to hazardous levels, building a major part of the exposome. This is of particular concern in low- and middle-income countries, such as Brazil, known as a leading producer of agricultural commodities and consumer of pesticides. As long as public policies continue to encourage the indiscriminate use of pesticides and governments continue to support this strategy instead of endorsing sustainable agricultural alternatives, the environmental burden that damages epithelial barriers will continue to grow. Chronic exposure to environmental contaminants in early life can affect crucial barrier tissue, such as skin epithelium, airways, and intestine, causing increased permeability, leaking, dysbiosis, and inflammation, with serious implications for metabolism and homeostasis. This vicious cycle of exposure to environmental factors and the consequent damage to the epithelial barrier has been associated with an increase in immune-mediated chronic inflammatory diseases. Understanding how the harmful effects of pesticides on the epithelial barrier impact cellular interactions mediated by endogenous sensors that coordinate a successful immune system represents a crucial challenge. In line with the epithelial barrier hypothesis, this narrative review reports the available evidence on the effects of pesticides on epithelial barrier integrity, dysbiosis, AhR signaling, and the consequent development of immune-mediated inflammatory diseases.

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Association between exposure to organophosphorus pesticides and the risk of diabetes among US Adults: Cross-sectional findings from the National Health and Nutrition Examination Survey

Cited by 45 publications

References 62 publications

Association of Visceral Fat Area and Hyperuricemia in Non-Obese US Adults: A Cross-Sectional Study

Association of Visceral Fat Area and Hyperuricemia in Non-Obese US Adults: A Cross-Sectional Study

Organophosphate pesticide exposure and biomarkers of liver injury/liver function

Pesticides and Their Impairing Effects on Epithelial Barrier Integrity, Dysbiosis, Disruption of the AhR Signaling Pathway and Development of Immune-Mediated Inflammatory Diseases

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