Association between exposure to perfluoroalkyl substances and metabolic syndrome and related outcomes among older residents living near a Science Park in Taiwan

Associations of Perfluoroalkyl Substances with Prevalence of Metabolic Syndrome in Highly Exposed Young Adult Community Residents—A Cross-Sectional Study in Veneto Region, Italy

“…In other epidemiological studies, inconsistent findings exist regarding the association between PFAS and MetS. Overall, no association was observed between PFOA, PFOS, PFHxS, and MetS in different cross-sectional studies, which is concordant with our analysis [15][16][17][18]21,30,36]. Only two studies one on a small scale (n = 148) of Chinese adult men (19-60 years old) and the other of 1501 adults from a cross-sectional study, the "Isomers of C8 Health Project in China" found a significant association between linear PFOA and the risk of MetS with ORs of 29.4 (95% CI, 2.90-299.7), after adjustment only for age [19] and 1.99 (95% CI, 1.40, 2.83) after adjustment for age, sex, income status, smoking status, alcohol consumption, regular exercise, seafood consumption, and eGFR [20].…”

“…In general, the observed pattern of PFAS levels, relating among participants defined by MetS criteria, were comparable with the results of the four cross-sectional studies. Overall, no association was observed between PFOA, PFOS, PFHxS, and MetS in different cross-sectional studies, which is concordant with our analysis [17][18][19][20]. For PFNA, the level in this study was relatively lower than the other studies.…”

“…Overall, the PFAS concentrations found in total serum in the young adult population was around five times higher for PFOA and PFHxS than the average burden reported for Europe 7.7 µg/mL and 0.67 µg/mL, respectively [9]. In contrast, the PFOS median concentration (3.7 µg/L) was significantly lower in our study population than the other studies [18,20] but in a roughly similar range to the median PFOS concentration of a Chinese adult population (3 µg/L) [19]. Nevertheless, the medians of serum PFOS concentration here were almost two times higher than the median concentrations in serum/plasma in the general adult population in Europe (1.9 µg/mL) [9].…”

“…Over the past decades, several lines of evidence have implicated an association between exposure to PFAS and higher serum cholesterol concentrations, hypertension, thyroid hormones, liver enzymes, and inconsistent results on perturbation of insulin and glucose homeostasis, markers of immunologic function, asthma, and children's behavior [13,14]. However, reported associations with metabolic syndrome (MetS) have so far been inconclusive, with conflicting findings reporting null [15][16][17][18], adverse [19,20], and even protective associations [21].…”

The Relationship Between the Metabolic Syndrome and the Place of Residence in the Local Community on the Example of the Janów Lubelski District in Eastern Poland: A Population-Based Study

“… 76 Exposure to chemicals in the environment positively correlates with the increase in the development of metabolic diseases. 77–79 Among the chemical substances present in the environment, phytates, 80 organophosphate esters, 81 perfluoroalkyl substances 82 or phenols and parabens, inter alia, increase the likelihood of MetS occurrence. 83 Heavy metals may also play an essential role in the development of not only cardiovascular complications 84 but also MetS, which due to the development of industry, traffic, smoking or changes in food production technology, constitute an imperative element of environmental pollution, also among residents of rural areas.…”