Association between exposure to polycyclic aromatic hydrocarbons and endometriosis: data from the NHANES 2001–2006

Zhang, Li; Yang, Xiaojun

doi:10.3389/fpubh.2023.1267124

Cited by 3 publications

References 37 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

Impact of urinary PAHs on psoriasis risk in U.S. adults: Insights from NHANES

Li,

Yan,

et al. 2024

PLoS ONE

View full text Add to dashboard Cite

Objective Exposure to environmental pollutants is increasingly recognized as a risk factor for the development of psoriasis. Polycyclic aromatic hydrocarbons (PAHs) are ubiquitous in the air and might induce reactions such as oxidative stress. Nevertheless, it is still unclear if PAHs have any influence on the prevalence of psoriasis over the entire population of the United States. The objective of this study was to assess the association between urine PAHs and psoriasis. Methods The research included 3,673 individuals aged 20 years or older who participated in the 2003–2006 and 2009–2012 National Health and Nutrition Examination Surveys (NHANES). We employed logistic regression models to evaluate the relationship between levels of urine PAH metabolites and psoriasis and smoothed curve fitting to illustrate the concentration-response relationship. Additionally, subgroup and interaction analyses were conducted to elucidate these associations. Furthermore, we employed weighted quartile sum (WQS) regressions to examine the distinct effects of individual and mixed urine PAH metabolites on psoriasis. However, it is important to note that the NHANES sample may be subject to selectivity and self-reporting bias, which may influence the data’ generalisability. Results We observed that the highest tertiles of 2-NAP and 2-FLU had a 63% (95% CI 1.02, 2.61) and 83% (95% CI 1.14, 2.96) higher odds of association with psoriasis prevalence, respectively. Meanwhile, tertile 2 and tertile 3 of 3-PHE were also significantly associated with psoriasis, with higher odds of 65% (95% CI 1.01, 2.69) and 14% (95% CI 1.17, 3.00), respectively. The subgroup analyses revealed a significant correlation between urine PAH metabolites and the odds of psoriasis in specific groups, including males, aged 40–60 years, with a BMI > 30, and those with hyperlipidemia. In the WQS model, a positive association was found between the combination of urine PAH metabolites and psoriasis (OR 1.43, 95% CI 1.11, 1.84), with 2-FLU being the most prevalent component across all mixtures (0.297). Conclusions Our findings indicate a significant association between urine PAH metabolites and the odds of psoriasis prevalence in adults. Among these metabolites, 2-FLU demonstrated the most prominent impact. Controlling PAH exposure, as an important strategy for minimizing exposure to environmental contaminants and lowering the risk of psoriasis, is critical for raising public knowledge about environmental health and preserving public health.

show abstract

Impact of urinary PAHs on psoriasis risk in U.S. adults: Insights from NHANES

Li,

Yan,

et al. 2024

PLoS ONE

View full text Add to dashboard Cite

show abstract

Association between oxidative balance score and endometriosis findings from NHANES 1999–2006

SU,

Du,

Liu

et al. 2024

Preprint

View full text Add to dashboard Cite

Aim The Oxidative Balance Score (OBS) functions as a measure for gauging the oxidative stress condition, OBS has been utilized to assess the overall oxidants and antioxidants exposure status in various chronic disease studies, Growing evidence suggests that oxidative stress is involved in the pathophysiologic mechanisms of endometriosis, The purpose of this study was to investigate the association between OBS and endometriosis in women between the ages of 20 and 54. Methods and Results The correlation between OBS and endometriosis was meticulously examined through a multifaceted approach, encompassing multivariate logistic regression, sensitivity analysis, and the application of smoothing techniques for curve fitting. This analysis was conducted utilizing the extensive dataset from the National Health and Nutrition Examination Survey (NHANES) spanning the years 1999 to 2006. To ascertain the stability of the observed relationship across diverse demographic segments, subgroup analysis, and interaction tests were meticulously implemented. Among the 3881 participants aged between 20 and 54 years, a significant inverse association was identified between OBS scores and the presence of endometriosis. Specifically, within the comprehensively adjusted model, for every 1 score increase in OBS, the odds of endometriosis prevalence decreased by 2.00%. The highest quartile of OBS demonstrated a 29.1% reduction in the prevalence of endometriosis when compared to those in the lowest quartile, with a confidence interval of [0.480, 1.048], underscoring the robustness of the observed trend. Conclusions OBS is related to endometriosis among American adults. Our results suggest that elevated OBS may potentially reduce the odds of endometriosis prevalence.

show abstract

Associations between C-reactive protein-triglyceride glucose index and Endometriosis: the NHANES 1999-2006

Ren,

Xu,

Zhang

et al. 2024

Preprint

View full text Add to dashboard Cite

Background: The C-reactive protein-triglyceride glucose index (CTI), a promising new marker, could evaluate the extent of inflammation. Endometriosis is a prevalent chronic inflammatory condition that is influenced by estrogen and primarily impacts individuals of reproductive age. However, no investigated have shown association of the CTI with endometriosis. Methods: In total, 2235 women in National Health and Nutrition Examination Survey from the 1999-2006 were included. The CTI was deﬁned as 0.412 × ln (CRP) + ln [T.G. (mg/dL) × FPG (mg/dL)/2]. Multivariate logistic regression, restricted cubic splines, and subgroup analyses were employed to examine the association of CTI with endometriosis. Results：Totally 2235 women were included, of whom 175 (7.82%) had endometriosis and 2060(92.18%) did not have endometriosis (named control). In comparison to the control group, patients exhibited a tendency toward higher CTI levels (P =0.005). CTI levels were positive associated with the prevalence of endometriosis (P =0.011). In Model 1, 1 mg/dL increment in CTI was associated with a 56% higher prevalence of endometriosis (OR: 1.563, 95% CI: 1.295–1.885, P < 0.001). This association in Model 2 (OR: 1.609, 95% CI: 1.334-1.941, P ＜ 0.001) and Model 3 (OR: 1.565, 95% CI: 1.246–1.966, P < 0.001) remained significant. Notably, individuals in the uppermost RC tertial exhibited a notably greater prevalence of endometriosis than those in the lowest tertial (OR = 3.029, P for trend = 0.051). The results from the restricted cubic splines indicated a nonlinear positive association between CTI and the prevalence of endometriosis. In addition, the higher endometriosis prevalence with CTI in >40 years (OR = 1.57, 95% CI:1.16 , 2.13), BMI ≥25 kg/m2 (OR =1.38, 95% CI: 1.06,1.80), smoking ≥ 100 cigarettes (OR =1.43, 95% CI: 1.06, 1.96), married or living with partner (OR =1.41, 95% CI: 1.09, 1.85) and taking oral contraceptives (OR =1.35, 95% CI: 1.07, 1.69) was observed. Conclusions: CTI is positively associated with endometriosis in US women. Therefore, the use of CTI as a new indicator of inflammation may help provide new insights into the prevention and management of endometriosis.

show abstract

Association between exposure to polycyclic aromatic hydrocarbons and endometriosis: data from the NHANES 2001–2006

Cited by 3 publications

References 37 publications

Impact of urinary PAHs on psoriasis risk in U.S. adults: Insights from NHANES

Impact of urinary PAHs on psoriasis risk in U.S. adults: Insights from NHANES

Association between oxidative balance score and endometriosis findings from NHANES 1999–2006

Associations between C-reactive protein-triglyceride glucose index and Endometriosis: the NHANES 1999-2006

Contact Info

Product

Resources

About