Association between Family History of Stroke and Stroke Risk: A Community Survey

Claeys, Jane; Gurvich, Olga V; Hadidi, Niloufar Niakosari

doi:10.1177/0193945920957935

Cited by 6 publications

(3 citation statements)

References 17 publications

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“…Among patients with AF, having a sibling who has had an ischemic stroke increased the risk of stroke and all-cause mortality [ 52 ]. Family history of stroke was also associated with a higher calculated risk of stroke as determined by the ASA Risk Score [ 53 ], but not with the LS7 score [ 9 ].…”

Section: Resultsmentioning

confidence: 99%

Family history of stroke – a useful clue for the primary care physician and stroke neurologist: a narrative review

Błaż¹,

Sarzyńska‐Długosz²

2023

ppn

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Purpose:The heritability of ischemic stroke is a complex mechanism, involving the contribution of genetic traits and environmental factors, which is why in everyday practice clinicians often rely on the broad term "family history of stroke", defined as the case of any first-degree relative who has had a stroke. The aim of this review is to update the available data regarding family history of stroke in primary and secondary stroke prevention by searching the electronic Scopus database for the phrase TITLE-ABS-KEY ("family history" AND "stroke"). Views: A total of 140 articles met the pre-specified criteria and were included in the review. The prevalence of family history of stroke ranged from 37% in stroke-free individuals to 52% in patients with ischemic stroke. In primary prevention, family history of stroke was associated with increased risk of stroke, transient ischemic attack, stroke risk factors and stroke-like symptoms. In patients with ischemic stroke, it was more often associated with small-and large-vessel disease, though not with a cardioembolic etiology. Family history of stroke did not influence long-term functional outcomes after rehabilitation. In young stroke victims, it was related to symptom severity and the risk of a second stroke. Conclusions: Consideration of family history of stroke in everyday practice may carry useful information both for primary care physicians and stroke neurologists.

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Section: Resultsmentioning

confidence: 99%

Family history of stroke – a useful clue for the primary care physician and stroke neurologist: a narrative review

Błaż¹,

Sarzyńska‐Długosz²

2023

ppn

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“…According to the current statistics, stroke caused by cerebrovascular diseases has become the second leading cause of death in industrialized countries and the most common reason for permanent acquired disability (O'Donnell et al, 2016). Therefore, increasing studies have concentrated on risk factors for cerebrovascular diseases (Boehme et al, 2017;Cipolla et al, 2018;Claeys et al, 2020). Early intervention in the associated risk factors can reduce the incidence of cerebrovascular disease.…”

Section: Introductionmentioning

confidence: 99%

The role of the gut microbiome and its metabolites in cerebrovascular diseases

Long

et al. 2023

Front. Microbiol.

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The gut microbiome is critically involved in maintaining normal physiological function in the host. Recent studies have revealed that alterations in the gut microbiome contribute to the development and progression of cerebrovascular disease via the microbiota-gut-brain axis (MGBA). As a broad communication network in the human body, MGBA has been demonstrated to have significant interactions with various factors, such as brain structure and function, nervous system diseases, etc. It is also believed that the species and composition of gut microbiota and its metabolites are intrinsically linked to vascular inflammation and immune responses. In fact, in fecal microbiota transplantation (FMT) research, specific gut microbiota and downstream-related metabolites have been proven to not only participate in various physiological processes of human body, but also affect the occurrence and development of cerebrovascular diseases directly or indirectly through systemic inflammatory immune response. Due to the high mortality and disability rate of cerebrovascular diseases, new treatments to improve intestinal dysbacteriosis have gradually attracted widespread attention to better ameliorate the poor prognosis of cerebrovascular diseases in a non-invasive way. This review summarizes the latest advances in the gut microbiome and cerebrovascular disease research and reveals the profound impact of gut microbiota dysbiosis and its metabolites on cerebrovascular diseases. At the same time, we elucidated molecular mechanisms whereby gut microbial metabolites regulate the expression of specific interleukins in inflammatory immune responses. Moreover, we further discuss the feasibility of novel therapeutic strategies targeting the gut microbiota to improve the outcome of patients with cerebrovascular diseases. Finally, we provide new insights for standardized diagnosis and treatment of cerebrovascular diseases.

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“…Increased salt intake [9][10][11] exposure to environmental factors, family history studies [12] ecological correlation between low birth weight and risk of later stroke have all contributed to the stroke menace. [13] Others such as genetic factors can act at several levels, they contribute to conventional risk factors such as hypertension ,diabetes or increased homocysteine concentrations [14,15] and they could also affect latency to stroke ,infarct size or stroke outcome [16,17].There have been studies investigating potential risk genes for common multifactorial stroke such as Single -gene disorders ,Cerebral autosomal dominant arteriopathy with sub cortical infarcts and leuconcephalopathy(CADASIL), Fabry's disease, sickle -cell disease, connective tissue disorders most of these are associated with young stroke patients ,children and ischaemic stroke.…”

Section: Introductionmentioning

confidence: 99%

Case Fatality Rate and Prognosis of Stroke Hospitalized Patients: A retrospective hospital-based study at the Korle Bu Teaching Hospital

Ofei-Palm

Osei²,

Obuobi

et al. 2022

GJCD

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Introduction: Stroke is associated with high mortality. It is the main neurological cause of mortality and the most important cause of disability worldwide. In the year 2007, Stroke was the third cause of admission at the Korle-Bu Teaching Hospital, and the number one cause of death. Objective: To determine the probability of survival (case-fatality rates) of stroke patients admitted at the Korle-Bu Teaching Hospital during the period 2007. Method: A Retrospective descriptive study of Surgical/Medical Emergency, SME and the Medical wards admissions and discharges from 1st January 2007 to 31st December, 2007. Results: A total of 250 hospitalized stroke patients were identified, of which 68(27%) were from the SME and 182(72%) from the medical wards. The mean age (SD) was 57.6(14.7) and 52% were males. Case fatality rate was 52% at the SME versus 35% at the Medical wards) whilst the risk of death in males expressed as risk ratio (RR) was 2.1, (95% CI 0.70-5.6) vs. RR=1.3, (95% CI 0.73-2.5) in females and the median survival time was 2days (95% CI 1.5-2.4) versus 7 days (95% CI 6.3-7.6) at the SME and Medical respectively. The type of admission and stroke outcome was significant P=0.01 (95%CI 0.02-0.14). Conclusion: Stroke was associated with high mortality. The risk of dying from stroke was higher at the SME Findings were independent of stroke subtype, stroke onset and any associated co-morbidities.

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Association between Family History of Stroke and Stroke Risk: A Community Survey

Cited by 6 publications

References 17 publications

Family history of stroke – a useful clue for the primary care physician and stroke neurologist: a narrative review

Family history of stroke – a useful clue for the primary care physician and stroke neurologist: a narrative review

The role of the gut microbiome and its metabolites in cerebrovascular diseases

Case Fatality Rate and Prognosis of Stroke Hospitalized Patients: A retrospective hospital-based study at the Korle Bu Teaching Hospital

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