Association between fetal exposure to polycyclic aromatic hydrocarbons and low birth weight: a case–control study in Shenzhen, China

Jiang, Lei; Xiao, Qinru; Zhao, Yang; Chen, Lihua; Lu, Shaoyou

doi:10.1007/s11356-022-21965-6

Cited by 12 publications

(4 citation statements)

References 39 publications

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“…In the paired serum and urine samples, the concentration of PAHs with two rings constituted 68.36% and 90.07% of the total PAHs in the serum and urine, respectively (Figure ). This finding supports the conclusion that the proportion of low molecular weight PAHs was higher than that of high molecular weight PAHs, which aligns with the findings of several related studies. − The correlation analysis of PAH concentrations in serum (Figure S1) revealed significant associations among the majority of the PAH compounds, indicating a potentially single-exposure source for PAHs in our study. The lack of correlations between Nap and other PAHs is not unexpected, as previous studies have demonstrated that Nap exhibits distinct behavior compared to other PAHs due to its lower molecular weight and boiling point .…”

Section: Resultssupporting

confidence: 92%

“…Compared to other comparable studies, the concentration of p-PAHs in our study participants was significantly higher than that observed in the general population but similar to levels observed in individuals residing or working in industrial areas (Table S6). The findings from these cohort studies have demonstrated a significant association between PAH exposure levels and various diseases, including obesity, adverse birth outcomes, and hypertension, − but the corresponding urine studies have shown that the daily intake is well below the risk value (Table S7). As pointed out in previous studies, , there may be a serious underestimation in the assessment of daily intake by OH-PAHs.…”

Section: Resultsmentioning

confidence: 99%

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Differential Occupational Health Risks between Methylated PAHs and PAHs: Monitoring 126 PAHs and 6 Oxidative Stress Markers in Paired Serum–Urine Samples

Zhao,

Jiang,

Han

et al. 2024

Environ. Health

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The hazards of polycyclic aromatic hydrocarbons (PAHs) on occupationally exposed population have been widely acknowledged. However, the occupational exposure risks associated their derivatives, methylated PAHs, remain poorly understood. This study conducted a screen of 126 PAHs and 6 oxidative stress biomarkers (OSBs) in paired serum−urine samples from 110 petrochemical workers to assess the risk associated with different PAHs exposure. The results showed that the median concentrations of unmetabolized 16 priority PAHs (p-PAHs), 16 regular PAHs (R-PAHs), 50 methyl-PAHs (Me-PAHs), and 30 nitro-PAHs (N-PAHs) in serum (urine) were 97.98 (66.46), 11.02 (0.00), 77.76 (31.77), and 1.93 (0.10) ng/mL, respectively. The median concentration of metabolized hydroxy PAHs (OH-PAHs) in urine was 12.00 ng/mL (9.49 ng/mg creatinine). OSBs indicate that the hazards of Me-PAHs on exposed populations manifest as protein damage, while the hazards of p-PAHs mainly result in lipid and DNA damage. Results from common diseases and PAH exposure demonstrate a correlation between liver damage and PAH exposure, and Me-PAHs are more difficult to metabolize through urine due to their stronger lipophilicity. This study suggests that traditional health screenings targeting p-PAHs may be insufficient and likely underestimate the exposure risks for occupational populations.

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Section: Resultssupporting

confidence: 92%

Section: Resultsmentioning

confidence: 99%

Differential Occupational Health Risks between Methylated PAHs and PAHs: Monitoring 126 PAHs and 6 Oxidative Stress Markers in Paired Serum–Urine Samples

Zhao,

Jiang,

Han

et al. 2024

Environ. Health

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“…This could be the cause of the study sample's marginally elevated chance of abortion [37]. Comparable results were seen in a Chinese case-control study investigating the relationship between maternal serum PAH concentrations and low birth weight (LBW): A logistic regression analysis revealed a positive correlation between LBW and the PAH component acenaphthene in the mothers' peripheral blood [38]. Once more, evidence demonstrates that some PAH constituents are detrimental to fetal development.…”

Section: Discussionmentioning

confidence: 75%

Link between Oil Pollution and Adverse Pregnancy Outcomes in the Niger Delta Region of Nigeria

Kanu,

Iwunze

2024

AJMAH

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Oil exploration in the Niger Delta has led to severe environmental pollution. This study investigates the association between exposure to crude oil and adverse pregnancy outcomes. Study Design: This was a comparative cross-sectional study of the differences in adverse pregnancy outcomes of people living in heavily oil polluted and non-polluted communities Place and Duration of Study: Kegbara Dere (K-Dere), a rural Community in Ogoniland, Gokana Local Government Area, Rivers State and Obohia community in Ndoki kingdom, Ukwa East LGA of Abia state between June 2022 and Jan 2023. Methodology: We recruited 900 study participants (450 each from the crude oil impacted and the non-oil polluted communities) using multi-stage random sampling. Questionnaires were used to collect data on socio-demographics and adverse pregnancy history by case definitions using the adapted WHO indirect sisterhood method of maternal mortality estimate. Data was analyzed using IBM Statistical Package for Social Sciences (SPSS) version 25. Differences in proportions were compared using Chi Square test. The association between living in an oil polluted community or exposure to crude oil pollutants and adverse pregnancy outcomes was determined using crude odds ratio. Confidence intervals were determined at 95% level and a p-value of less than 0.05 was considered significant. Results: Pregnant women in the polluted community experienced a significantly higher prevalence of adverse outcomes, including stillbirth, abortion, and birth defects. The risk of experiencing an adverse pregnancy outcome was 30 times higher in the polluted area. Conclusion: This study suggests a strong link between oil pollution and pregnancy complications. Further research with robust designs is needed to confirm causality. Environmental cleanup and protective measures for pregnant women are crucial in these areas.

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“…PAHs and PAEs can enter the body through inhalation, ingestion and dermal contact and are excreted in urine and faeces. Studies have shown that PAH and PAE can cross the placenta from maternal serum into the foetal circulation [ 2 , 3 ], with potential implications for maternal and child health [ 4 , 5 , 6 , 7 , 8 , 9 ]. The placenta is highly sensitive to EEDs because it is rich in hormone receptors.…”

Section: Introductionmentioning

confidence: 99%

Determination of Polycyclic Aromatic Hydrocarbons (PAHs) and Phthalates in Human Placenta by Mixed Hexane/Ether Extraction and Gas Chromatography–Mass Spectrometry/Mass Spectrometry (GC-MS/MS)

Tao,

Tian,

Liao

et al. 2023

Metabolites

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In this study, we evaluated the extraction effect of three different extractants, namely hexane + ether (v/v = 3:1), acetonitrile and ethyl acetate, on polycyclic aromatic hydrocarbons (PAHs) and phthalic acid esters (PAEs) in placenta detected and analysed by triple quadrupole gas chromatography–mass spectrometry (GC-MS/MS). The results showed that n-hexane + ether (v/v = 3:1) had the highest extraction efficiency. Under the optimal conditions, the limits of detection (LOD) for the 10 PAHs were 0.003–0.0167 μg/L with relative standard deviations (RSD) of 1.4–5.48% and detection rates of 68.19–107.05%, and the correlation coefficients were (R2, 0.9982–0.9999). The LODs for the nine PAEs were 0.0015–3.5714 μg/L and the correlation coefficients were (R2, 0.9982–0.9999). The limits of detection (S/N = 3) for the nine PAHs were 0.0015–0.5714 μg/L with relative standard deviations (RSD) of 3.15–8.37%, and the detection rates were 80.45–112.59% with correlations of (R2, 0.9972–0.9998). The method was applied to the analysis of PAHs and phthalates in placenta samples from pregnant women. The method’s accuracy and applicability were demonstrated. In comparison with other methods for the detection of PAEs and PAHs, the method proposed in this paper has a wider linear range, lower minimum detection limit and comparable recovery with good correlation. This paper is dedicated to providing another method for improving the performance of extracting solid tissues.

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Association between fetal exposure to polycyclic aromatic hydrocarbons and low birth weight: a case–control study in Shenzhen, China

Cited by 12 publications

References 39 publications

Differential Occupational Health Risks between Methylated PAHs and PAHs: Monitoring 126 PAHs and 6 Oxidative Stress Markers in Paired Serum–Urine Samples

Differential Occupational Health Risks between Methylated PAHs and PAHs: Monitoring 126 PAHs and 6 Oxidative Stress Markers in Paired Serum–Urine Samples

Link between Oil Pollution and Adverse Pregnancy Outcomes in the Niger Delta Region of Nigeria

Determination of Polycyclic Aromatic Hydrocarbons (PAHs) and Phthalates in Human Placenta by Mixed Hexane/Ether Extraction and Gas Chromatography–Mass Spectrometry/Mass Spectrometry (GC-MS/MS)

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