Association between filaggrin null mutations and concomitant atopic dermatitis and contact allergy

Carlsen, Berit Christina; Thyssen, Jacob P.; Menné, Torkil; Meldgaard, Michael; Linneberg, Allan; Nielsen, Niels; Szecsi, Pal B.; Stender, Steen; Johansen, Jeanne Duus

doi:10.1111/j.1365-2230.2010.03994.x

Cited by 23 publications

(18 citation statements)

References 26 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Furthermore, ADFM and ADWT showed similar impairments in cutaneous immunity to DNCB, suggesting that the immune dysregulation is not FLG dependent but is due to other AD-specific epidermal factors and may be protective against more inflammatory Th1 responses classically associated with ACD. These findings are in line with clinical observations reporting a lack of association between FLG mutations with a phenotype of patients with both AD and ACD (Carlsen et al, 2011). Nickel ACD has been reported to associate with the presence of FLG mutations (Thyssen et al, 2008), but others have only found a nonsignificant trend toward this finding (Carlsen et al, 2010).…”

Section: Or (B) Ifn-g Production By Peripheral Blood Mononuclear Cellsupporting

confidence: 88%

Sensitization via Healthy Skin Programs Th2 Responses in Individuals with Atopic Dermatitis

Newell

Polak

Perera

et al. 2013

Journal of Investigative Dermatology

114

View full text Add to dashboard Cite

Allergen-specific responses in atopic dermatitis (AD) are skewed toward a Th2 profile. However, individuals with AD have been shown to make effective virus-specific Th1 responses, raising the possibility that the skin itself contributes to driving the AD Th2 immunophenotype. Therefore, to explore the programming of immunological sensitization by the skin, we examined the outcome of sensitization through non-lesional skin of individuals with AD and healthy controls. Volunteers (controls, AD individuals with filaggrin gene (FLG) mutations (ADFM), and AD individuals without FLG mutations (ADWT)) were sensitized by cutaneous application of 2,4-dinitrochlorobenzene (DNCB), a small, highly lipophilic chemical sensitizer. At the doses tested, DNCB showed equal penetration into skin of all groups. Clinical reactions to DNCB were significantly reduced in AD. Although both controls and AD made systemic DNCB-specific Th1 responses, these were reduced in AD and associated with significantly Th2-skewed DNCB-specific T-cell responses. Th2 skewing was seen in both ADFM and ADWT, with no difference between these groups. After 3 months, DNCB-specific Th2 responses were persistent in individuals with AD, and Th1 responses persisted in controls. These data provide evidence that when antigen penetration is not limiting, AD skin has a specific propensity to Th2 programming, suggesting the existence of altered skin immune signaling that is AD-specific and independent of FLG status.

show abstract

Section: Or (B) Ifn-g Production By Peripheral Blood Mononuclear Cellsupporting

confidence: 88%

Sensitization via Healthy Skin Programs Th2 Responses in Individuals with Atopic Dermatitis

Newell

Polak

Perera

et al. 2013

Journal of Investigative Dermatology

114

View full text Add to dashboard Cite

show abstract

“…11,17 However, other studies have found that irritant contact dermatitis and contact allergy are associated with FLG mutations but only in the presence of atopy. 32,33 Hence, we do not suspect that misclassification would be differentially related to FLG genotype. Finally, the participation rate was higher among the older age groups 34 but because age differences were not dependent on genotype, we do not consider this to affect the outcome of the study.…”

Section: Discussionmentioning

confidence: 98%

Anatomical patterns of dermatitis in adult filaggrin mutation carriers

Heede

Thyssen

Thuesen

et al. 2015

Journal of the American Academy of Dermatology

View full text Add to dashboard Cite

“…When genotyping and patch testing 430 Caucasians in Denmark, Carlsen et al did not fi nd a positive association between FLG mutations and contact sensitization [ 66 ]. Moreover, the subgroup of patients with AD and concomitant contact sensitization did not have a signifi cantly higher prevalence of FLG mutations compared with patients with positive patch test without AD, or compared with the general population [ 67 ].…”

Section: Cause Of Hand Eczemamentioning

confidence: 96%

Hand Eczema

Brans¹,

John²

2014

Filaggrin

View full text Add to dashboard Cite

Association between filaggrin null mutations and concomitant atopic dermatitis and contact allergy

Abstract: The spectrum of observable traits characteristic for the FLG mutation genotype in patients with AD is at present not defined. Our results indicate that the subset of patients with both AD and CA represent a phenotype of AD that is not associated with FLG mutations.

Cited by 23 publications

References 26 publications

Sensitization via Healthy Skin Programs Th2 Responses in Individuals with Atopic Dermatitis

Sensitization via Healthy Skin Programs Th2 Responses in Individuals with Atopic Dermatitis

Anatomical patterns of dermatitis in adult filaggrin mutation carriers

Hand Eczema

Contact Info

Product

Resources

About