Association between fine particulate matter and atrial fibrillation in implantable cardioverter defibrillator patients: a systematic review and meta-analysis

Yue, Chao; Yang, Fan; Wang, Luyi; Li, Fengwei; Chen, Yingtai

doi:10.1007/s10840-020-00864-1

Cited by 12 publications

(8 citation statements)

References 36 publications

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“…Increased short‐term exposure to PM 2.5 (2/2), PM 10 (1/1), and NO 2 (2/2) was associated with increased atrial fibrillation (Figs 3, 4, and S1). Another meta‐analysis [65] found that a 10 μg/m 3 increase in PM 2.5 was associated with a 24.00% (0.00; 53.00) excess risk of atrial fibrillation in patients with an implantable cardioverter‐defibrillator (Fig. 3).…”

Section: Resultsmentioning

confidence: 99%

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Ambient air pollution and cardiovascular diseases: An umbrella review of systematic reviews and meta‐analyses

et al. 2022

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The available evidence on the effects of ambient air pollution on cardiovascular diseases (CVDs) has increased substantially. In this umbrella review, we summarized the current epidemiological evidence from systematic reviews and meta‐analyses linking ambient air pollution and CVDs, with a focus on geographical differences and vulnerable subpopulations. We performed a search strategy through multiple databases including articles between 2010 and 31 January 2021. We performed a quality assessment and evaluated the strength of evidence. Of the 56 included reviews, the most studied outcomes were stroke (22 reviews), all‐cause CVD mortality, and morbidity (19). The strongest evidence was found between higher short‐ and long‐term ambient air pollution exposure and all‐cause CVD mortality and morbidity, stroke, blood pressure, and ischemic heart diseases (IHD). Short‐term exposures to particulate matter <2.5 μm (PM2.5), <10 μm (PM10), and nitrogen oxides (NOx) were consistently associated with increased risks of hypertension and triggering of myocardial infarction (MI), and stroke (fatal and nonfatal). Long‐term exposures of PM2.5 were largely associated with increased risk of atherosclerosis, incident MI, hypertension, and incident stroke and stroke mortality. Few reviews evaluated other CVD outcomes including arrhythmias, atrial fibrillation, or heart failure but they generally reported positive statistical associations. Stronger associations were found in Asian countries and vulnerable subpopulations, especially among the elderly, cardiac patients, and people with higher weight status. Consistent with experimental data, this comprehensive umbrella review found strong evidence that higher levels of ambient air pollution increase the risk of CVDs, especially all‐cause CVD mortality, stroke, and IHD. These results emphasize the importance of reducing the alarming levels of air pollution across the globe, especially in Asia, and among vulnerable subpopulations.

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Section: Resultsmentioning

confidence: 99%

“…There were four meta-analyses that evaluated the short-and long-term effect of air pollution on atrial fibrillation [24,[64][65][66]. Increased short-term exposure to PM 2.5 (2/2), PM 10 (1/1), and NO 2 (2/2) was associated with increased atrial fibrillation (Figs 3, 4, and S1).…”

Section: Arrhythmias Atrial Fibrillation and Cardiac Arrestmentioning

confidence: 99%

Ambient air pollution and cardiovascular diseases: An umbrella review of systematic reviews and meta‐analyses

et al. 2022

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“…Initial studies have reported a significant association between increased PM 2.5 levels and an elevated risk of AF, particularly among older adults and patients with implantable cardioverter-defibrillators (ICDs). 31,32 In a cohort study of patients followed in a medical center in Boston, MA, investigators noted that short-term exposure to PM 2.5 acts as an acute trigger for AF, with a 26% increased risk observed for every 6.0 μg/m³ increase in PM 2.5 levels in the 2 hours preceding an AF event. 31 However, not all studies have consistently demonstrated a positive correlation between long-term PM 2.5 exposure and AF risk.…”

Section: Figure 2 Exposure-response Relationship Curves Between Fine ...mentioning

confidence: 99%

Environmental Exposome and Atrial Fibrillation: Emerging Evidence and Future Directions

Wass,

Hahad,

Asad

et al. 2024

Circulation Research

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There has been increased awareness of the linkage between environmental exposures and cardiovascular health and disease. Atrial fibrillation is the most common sustained cardiac arrhythmia, affecting millions of people worldwide and contributing to substantial morbidity and mortality. Although numerous studies have explored the role of genetic and lifestyle factors in the development and progression of atrial fibrillation, the potential impact of environmental determinants on this prevalent condition has received comparatively less attention. This review aims to provide a comprehensive overview of the current evidence on environmental determinants of atrial fibrillation, encompassing factors such as air pollution, temperature, humidity, and other meteorologic conditions, noise pollution, greenspace, and the social environment. We discuss the existing evidence from epidemiological and mechanistic studies, critically evaluating the strengths and limitations of these investigations and the potential underlying biological mechanisms through which environmental exposures may affect atrial fibrillation risk. Furthermore, we address the potential implications of these findings for public health and clinical practice and identify knowledge gaps and future research directions in this emerging field.

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“…There were meta-analyses that investigated the association between PM and cardiac arrhythmias, but almost all of them focused specifically on AF, which is only one type of cardiac arrhythmia. Furthermore, none of them performed a subgroup analysis of diabetic status [18][19][20][21][22]. Only one meta-analysis was conducted to find the association between PM and AF with the subgroup analysis; they found that exposure to PM was associated with the onset of AF episodes, but the modifying effect of diabetic status was not observed [21].…”

Section: Introductionmentioning

confidence: 99%

Effect modification of diabetic status on the association between exposure to particulate matter and cardiac arrhythmias in a general population: A systematic review and meta-analysis

Tassanaviroj,

Plodpai,

Wongyikul

et al. 2024

PLoS ONE

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Particulate matter (PM) has various health effects, including cardiovascular diseases. Exposure to PM and a diagnosis of diabetes mellitus (DM) have been associated with an increased risk of cardiac arrhythmias. However, no comprehensive synthesis has been conducted to examine the modifying effect of DM on the association between PM and arrhythmia events. Thus, the objectives of this review were to investigate whether the association of PM is linked to cardiac arrhythmias and whether DM status modifies its effect in the general population. The search was conducted on PubMed/MEDLINE and Embase until January 18, 2023. We included cohort and case-crossover studies reporting the effect of PM exposure on cardiac arrhythmias and examining the role of diabetes as an effect modifier. We used the DerSimonian and Laird random-effects model to calculate the pooled estimates. A total of 217 studies were found and subsequently screened. Nine studies met the inclusion criteria, and five of them were included in the meta-analysis. The participants numbered 4,431,452, with 2,556 having DM. Exposure to PM of any size showed a significant effect on arrhythmias in the overall population (OR 1.10, 95% CI 1.04–1.16). However, the effect modification of DM was not significant (OR 1.18 (95% CI 1.01–1.38) for DM; OR 1.08 (95% CI 1.02–1.14) for non-DM; p-value of subgroup difference = 0.304). Exposure to higher PM concentrations significantly increases cardiac arrhythmias requiring hospital or emergency visits. Although the impact on diabetic individuals is not significant, diabetic patients should still be considered at risk. Further studies with larger sample sizes and low bias are needed.

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Association between fine particulate matter and atrial fibrillation in implantable cardioverter defibrillator patients: a systematic review and meta-analysis

Cited by 12 publications

References 36 publications

Ambient air pollution and cardiovascular diseases: An umbrella review of systematic reviews and meta‐analyses

Ambient air pollution and cardiovascular diseases: An umbrella review of systematic reviews and meta‐analyses

Environmental Exposome and Atrial Fibrillation: Emerging Evidence and Future Directions

Effect modification of diabetic status on the association between exposure to particulate matter and cardiac arrhythmias in a general population: A systematic review and meta-analysis

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