Association between flavonoid intake and diabetes risk among the Koreans

Yeon, Jee-Young; Bae, Yun Jung; Kim, Eun Young; Lee, Eun‐Ju

doi:10.1016/j.cca.2014.10.042

Cited by 35 publications

(33 citation statements)

References 43 publications

(46 reference statements)

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“…In addition, a small number of studies on the estimation of flavonoid intakes and their major dietary sources has been published, but most of these studies have targeted populations other than Korean (34)(35)(36) . A few studies that have focused on the flavonoid intake of Koreans have reported intakes only from fruits and vegetables (37,38) or are based on foreign databases (39) .…”

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confidence: 99%

Estimation of dietary flavonoid intake and major food sources of Korean adults

2015

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Epidemiological studies have suggested that flavonoids exhibit preventive effects on degenerative diseases. However, lack of sufficient data on flavonoid intake has limited evaluating the proposed effects in populations. Therefore, we aimed to estimate the total and individual flavonoid intakes among Korean adults and determine the major dietary sources of these flavonoids. We constructed a flavonoid database of common Korean foods, based on the food list reported in the 24-h recall of the Korea National Health and Nutrition Examination Survey (KNHANES) 2007-2012, using data from the Korea Functional Food Composition Table, US Department of Agriculture flavonoid database, Phenol-Explorer database and other analytical studies. This database, which covers 49 % of food items and 76 % of food intake, was linked with the 24-h recall data of 33 581 subjects aged ≥19 years in the KNHANES 2007-2012. The mean daily intake of total flavonoids in Korean adults was 318·0 mg/d, from proanthocyanidins (22·3 %), flavonols (20·3 %), isoflavones (18·1 %), flavan-3-ols (16·2 %), anthocyanidins (11·6 %), flavanones (11·3 %) and flavones (0·3 %). The major contributing food groups to the flavonoid intake were fruits (54·4 %), vegetables (20·5 %), legumes and legume products (16·2 %) and beverages and alcohols (3·1 %), and the major contributing food items were apples (21·9 %), mandarins (12·5 %), tofu (11·5 %), onions (9·6 %) and grapes (9·0 %). In the regression analysis, the consumption of legumes and legume products, vegetables and fruits predicted total flavonoid intake the most. The findings of this study could facilitate further investigation on the health benefits of flavonoids and provide the basic information for establishing recommended flavonoid intakes for Koreans.

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confidence: 99%

Estimation of dietary flavonoid intake and major food sources of Korean adults

2015

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“…In Table 2 the results of studies that examined the association between polyphenol intake and cardiovascular diseases risk are reported [50,51,52,53,54,55,56,57,58,59,60,61,62,63,64,65,66,67,68,69,70,71,72,73]. Seven out of 24 studies were conducted in United States (US), 2 in South America, 12 in Europe, 3 in Asia (Figure 4A).…”

Section: Resultsmentioning

confidence: 99%

“…As regard T2D, 1 study performed in Poland showed an increased protection for total polyphenol intake higher than 2632 mg/day while mixed results were found in the other studies focused on total flavonoids and/or subclasses only in some cases able to demonstrate significant T2D risk reduction [53,55,61,62]. Finally, 1 study [67] reported an inverse association for both CV and T2D with the highest quartile of total flavonoids (585 mg/day).…”

Section: Resultsmentioning

confidence: 99%

Systematic Review on Polyphenol Intake and Health Outcomes: Is there Sufficient Evidence to Define a Health-Promoting Polyphenol-Rich Dietary Pattern?

et al. 2019

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Growing evidence support association between polyphenol intake and reduced risk for chronic diseases, even if there is a broad debate about the effective amount of polyphenols able to exert such protective effect. The present systematic review provides an overview of the last 10-year literature on the evaluation of polyphenol intake and its association with specific disease markers and/or endpoints. An estimation of the mean total polyphenol intake has been performed despite the large heterogeneity of data reviewed. In addition, the contribution of dietary sources was considered, suggesting tea, coffee, red wine, fruit and vegetables as the main products providing polyphenols. Total flavonoids and specific subclasses, but not total polyphenols, have been apparently associated with a low risk of diabetes, cardiovascular events and all-cause mortality. However, large variability in terms of methods for the evaluation and quantification of polyphenol intake, markers and endpoints considered, makes it still difficult to establish an evidence-based reference intake for the whole class and subclass of compounds. Nevertheless, the critical mass of data available seem to strongly suggest the protective effect of a polyphenol-rich dietary pattern even if further well targeted and methodologically sound research should be encouraged in order to define specific recommendations.

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“…Consumption of mekabu (sporophylls of Undaria pinnatifida ) with a white rice-based breakfast by healthy volunteers demonstrated a reduction of post-prandial glucose concentration and this was attributed to the content and viscosity of fucoxanthin in mekabu [ 46 ]. Recently, a study involving more than 4000 participants in Korea revealed that insulin level and insulin resistance were inversely associated with dietary intake of flavonols and flavones, thereby reducing the risk of T2DM [ 47 ]. However, not all of these studies fully elucidate the factors involved in beneficial properties of seaweed dietary intake in managing diabetes.…”

Section: Introductionmentioning

confidence: 99%

Potential Bioactive Compounds from Seaweed for Diabetes Management

et al. 2015

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Diabetes mellitus is a group of metabolic disorders of the endocrine system characterised by hyperglycaemia. Type II diabetes mellitus (T2DM) constitutes the majority of diabetes cases around the world and are due to unhealthy diet, sedentary lifestyle, as well as rise of obesity in the population, which warrants the search for new preventive and treatment strategies. Improved comprehension of T2DM pathophysiology provided various new agents and approaches against T2DM including via nutritional and lifestyle interventions. Seaweeds are rich in dietary fibres, unsaturated fatty acids, and polyphenolic compounds. Many of these seaweed compositions have been reported to be beneficial to human health including in managing diabetes. In this review, we discussed the diversity of seaweed composition and bioactive compounds which are potentially useful in preventing or managing T2DM by targeting various pharmacologically relevant routes including inhibition of enzymes such as α-glucosidase, α-amylase, lipase, aldose reductase, protein tyrosine phosphatase 1B (PTP1B) and dipeptidyl-peptidase-4 (DPP-4). Other mechanisms of action identified, such as anti-inflammatory, induction of hepatic antioxidant enzymes’ activities, stimulation of glucose transport and incretin hormones release, as well as β-cell cytoprotection, were also discussed by taking into consideration numerous in vitro, in vivo, and human studies involving seaweed and seaweed-derived agents.

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Association between flavonoid intake and diabetes risk among the Koreans

Cited by 35 publications

References 43 publications

Estimation of dietary flavonoid intake and major food sources of Korean adults

Estimation of dietary flavonoid intake and major food sources of Korean adults

Systematic Review on Polyphenol Intake and Health Outcomes: Is there Sufficient Evidence to Define a Health-Promoting Polyphenol-Rich Dietary Pattern?

Potential Bioactive Compounds from Seaweed for Diabetes Management

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