Association Between Flavonoid-Rich Fruit and Vegetable Consumption and Total Serum Bilirubin

Loprinzi, Paul D.; Mahoney, Sara E.

doi:10.1177/0003319714537111

Cited by 24 publications

(16 citation statements)

References 47 publications

(52 reference statements)

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“…32 The high-glucose diet has the same hyperbilirubimemic effect, whereas the low-fat diet acts in the opposite way. 33 The same hyperbilirubinemic effect was recently reported for the intake of flavonoid-rich fruits and vegetables, 34 and it is likely that many other nutrients might have a similar impact (also see below).…”

Section: Lifestyle Factorssupporting

confidence: 63%

Induction of Mild Hyperbilirubinemia: Hype or Real Therapeutic Opportunity?

Vı́tek

Bellarosa

Tiribelli

2019

Clin Pharma and Therapeutics

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Observational epidemiological studies showed that mild hyperbilirubinemia has beneficial effects on the prevention of cardiovascular disease, type 2 diabetes mellitus, and metabolic syndrome. In mammals, bilirubin plays a major role as a potent antioxidant. Uridine 5’‐diphospho‐glucuronosyl transferase (UGT)1A1 variants coding for bilirubin UDP‐glucuronosyl transferase resulting in mild hyperbilirubinemia (as in Gilbert syndrome (GS)) may confer a strong genetic advantage. Strategies to boost bioavailability of bilirubin or to mimic GS represent an attractive approach to prevent many oxidative stress and inflammation‐mediated diseases. Even a tiny, micromolar increase in serum bilirubin concentrations substantially decreases the risk of oxidative stress–mediated diseases. There are several possible ways to achieve this, including lifestyle changes, changes in dietary patterns, regular physical activities, or use of chemical drug or of specific plant products either in the form of regular food items or nutraceuticals. Further basic and experimental research is required to fully uncover this promising therapeutic field.

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Section: Lifestyle Factorssupporting

confidence: 63%

Induction of Mild Hyperbilirubinemia: Hype or Real Therapeutic Opportunity?

Vı́tek

Bellarosa

Tiribelli

2019

Clin Pharma and Therapeutics

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“…Briefly, participants were asked to report the proportion of time certain types of foods were eaten. For the present study, which is consistent with other studies ( Loprinzi and Mahoney, 2015 , Mahoney and Loprinzi, 2014 ), 15 [solid] fruits and vegetables rich in flavonoids (i.e., apples, grapes, strawberries, oranges, cooked greens, raw greens, carrots, string beans, peas, broccoli, onions, peppers, cucumbers, tomatoes, and lettuce) were identified by using the USDA flavonoid content of foods ( USDA, 2007 ). For each of the 15 food items, response options ranged from 1 to 11, and included never (1), 1–6 times/yr (2), 7–11 times/yr (3), 1 time/month (4), 2–3 times/month (5), 1 time/wk (6), 2 times/wk (7), 3–4 times/wk (8), 5–6 times/wk (9), 1 time/day (10), and 2 or more times/day (11).…”

Section: Introductionsupporting

confidence: 91%

Association between accelerometer-determined physical activity and flavonoid-rich fruit and vegetable consumption among a national sample of U.S. adults

Loprinzi

2016

Preventive Medicine Reports

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Few population studies have examined the association between accelerometer-assessed physical activity and dietary behavior. Further, no studies have systematically examined the association between accelerometer-assessed physical activity and flavonoid rich fruits and vegetables in a national sample. As a result, the purpose of this study was to examine the association between objectively measured physical activity and consumption of flavonoid rich fruits and vegetables among a national sample of U.S. adults. Data from the 2003–2006 National Health and Nutrition Examination Survey (NHANES) were used (N = 2949). Physical activity was measured via accelerometry and fruit and vegetable consumption was measured from the NHANES Food Frequency Questionnaire. After adjustments, moderate-to-vigorous physical activity was positively associated (p < 0.05) with apples (β = 0.30), grapes (β = 0.27), strawberries (β = 0.32), oranges (β = 0.35), raw greens (β = 0.19), carrots (β = 0.23), peppers (β = 0.29) and an overall flavonoid index variable (β = 2.34). Future studies employing a longitudinal design are needed to better understand the direction of the observed associations. If future studies do indeed support the possibility that physical activity may help to foster changes in dietary behavior, then this will have strong implications for health behavior interventions, particularly among individuals finding it difficult to change multiple health behaviors concurrently.

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“…The corresponding work showed a decrease in this value for populations who consumed either carbohydrate and calorie-rich foods or diet containing high fat and carbohydrate as compared with the standard normal diet (ρ < 0.001) [1,2]. This same pattern of results was also reported by [3] for frequent caffeine consumers.…”

Section: Introductionsupporting

confidence: 75%

“…In addition to the underlying health status, previous research revealed that one's blood bilirubin concentration would also be affected by the change in their dietary intake [1]. The corresponding work showed a decrease in this value for populations who consumed either carbohydrate and calorie-rich foods or diet containing high fat and carbohydrate as compared with the standard normal diet (ρ < 0.001) [1,2].…”

Section: Introductionmentioning

confidence: 99%

Investigation of gender and prandial state as factors affecting skin bilirubin level

Choong

Huong

2018

J. Phys.: Conf. Ser.

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Abstract. This paper demonstrates the use of the developed non-invasive optical system to measure differences in the mean concentration of skin bilirubin C bil(m) among individuals of different gender and at different prandial state. This system employed the use of color filters to allow an illumination of the selected skin site using light beams of centre wavelength 420 nm, 440 nm and 460 nm. The prediction of the required skin bilirubin concentration value is via Modified Lambert Beer law. This study conducted experiments on the back of the hand of twelve recruits. The results revealed a higher mean C bil(m) value of 0.25 ± 0.007 µmol/L for males as compared to 0.14 ± 0.0086 µmol/L measured for females. In addition, this work observed a decrease in the mean C bil(m) value for the ten recruits of mixed gender from 0.23 ± 0.06 µmol/L at preprandial phase to 0.18 ± 0.04 µmol/L during the postprandial period. This study concluded that the developed system is able to detect changes in the skin bilirubin concentration level with one's gender and prandial state as reported in literature. However, this system may be further improved for future clinical application on jaundiced patients.

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Association Between Flavonoid-Rich Fruit and Vegetable Consumption and Total Serum Bilirubin

Cited by 24 publications

References 47 publications

Induction of Mild Hyperbilirubinemia: Hype or Real Therapeutic Opportunity?

Induction of Mild Hyperbilirubinemia: Hype or Real Therapeutic Opportunity?

Association between accelerometer-determined physical activity and flavonoid-rich fruit and vegetable consumption among a national sample of U.S. adults

Investigation of gender and prandial state as factors affecting skin bilirubin level

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