Association between Fok1 and TaqI polymorphisms of vitamin D receptor gene with the severity of stenosis and calcification in carotid bulb in patients with ischemic stroke

Foroughinia, Farzaneh; Morovati, Najmeh; Safari, Anahid; Dianatpour, Mehdi; Jamhiri, Iman; Heydari, Seyed Taghi; Hooshmandi, Sedighe; Borhani‐Haghighi, Afshin

doi:10.1016/j.jocn.2022.01.009

Cited by 4 publications

(3 citation statements)

References 42 publications

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“…According to our previous study [26], there was no association between vitamin D levels and VDR polymorphisms. Therefore; this relationship was not investigated as an endpoint of this study.…”

Section: Study Endpointsmentioning

confidence: 77%

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Impact of vitamin D receptor gene polymorphisms (TaqI and BsmI) on the incidence and severity of coronary artery disease: a report from southern Iran

Akhlaghi

Firouzabadi

Foroughinia

et al. 2023

BMC Cardiovasc Disord

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Background The association of vitamin D level and vitamin D receptor (VDR) gene polymorphisms with the prevalence of coronary artery disease (CAD) has been evaluated in various studies; however, the reported results were inconsistent. Hence, we aimed to investigate the impact of two VDR gene polymorphisms, TaqI (rs731236) and BsmI (rs1544410), on the incidence and severity of CAD in Iranian population. Methods Blood samples were collected from 118 CAD patients underwent elective percutaneous coronary intervention (PCI) and 52 control subjects. Polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) was performed for genotyping. SYTNAX score (SS) was calculated as a grading tool for complexity of CAD by an interventional cardiologist. Results TaqI polymorphism of VDR was not associated with the incidence of CAD. A significant difference was observed between CAD patients and controls regarding BsmI polymorphism of VDR (p < 0.001). GA and AA genotypes was significantly associated with a decreased risk of CAD (p = 0.01, p-adjusted = 0.01 and p < 0.001, p-adjusted = 0.001 respectively). A allele of BsmI polymorphism was shown to have a protective effect against CAD (p < 0.001, p-adjusted = 0.002). No association was found between TaqI and BsmI polymorphisms of VDR and SS as a measure of CAD severity. Conclusion Association of BsmI genotypes with the incidence of CAD revealed that the genetic variation of VDR might play a role in the pathogenesis of CAD.

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Section: Study Endpointsmentioning

confidence: 77%

“…Genomic DNAs were extracted from whole blood using DNA extraction kit (Yekta tajhiz, Iran). To identify VDR gene polymorphisms (TaqI and BsmI), polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) was performed using specific primers listed in Table 1 [25,26].…”

Section: Biological Samples and Genotypingmentioning

confidence: 99%

Impact of vitamin D receptor gene polymorphisms (TaqI and BsmI) on the incidence and severity of coronary artery disease: a report from southern Iran

Akhlaghi

Firouzabadi

Foroughinia

et al. 2023

BMC Cardiovasc Disord

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“…Calcitriol commands synaptic structural protein synthesis, and calcium trafficking to mitigate damage, thus maintaining the structural conformation of BBB. Carotid bulb stenosis and calcification are occasionally associated with ischemic stroke due to Fok I and Taq I polymorphisms of the vitamin D receptor (VDR) gene [ [7] , [8] , [9] ].…”

mentioning

confidence: 99%